Celecoxib leads to G2/M arrest by induction of p21 and down-regulation of cyclin B1 expression in a p53-independent manner

European Journal of Cancer

Volumn 42, Issue 3, 2006, Pages 422-426

  Dvory Sobol, Hadas ^a,b   Cohen Noyman, Efrat ^a,b   Kazanov, Diana ^a   Figer, Arie ^a,b   Birkenfeld, Shlomo ^a,b   Madar Shapiro, Liora ^a   Benamouzig, Robert ^c   Arber, Nadir ^a,b  

^a TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c AVICENNE HOSPITAL   (France)

Author keywords

Celecoxib; Cell cycle; Colorectal cancer; COX 2; p21; p53

Indexed keywords

CELECOXIB; CYCLIN B1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; PROSTAGLANDIN E2; PROTEIN P21; PROTEIN P53; CDKN1A PROTEIN, MOUSE; CYCLIN B; CYCLIN DEPENDENT KINASE INHIBITOR 1A; PYRAZOLE DERIVATIVE; SULFONAMIDE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL GROWTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; GROWTH INHIBITION; IN VITRO STUDY; INTESTINE CELL; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN TRANSPORT; RAT; UPREGULATION; ANIMAL; COLORECTAL TUMOR; DRUG EFFECT; FLOW CYTOMETRY; HUMAN; METABOLISM; ONCOGENE RAS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; COLORECTAL NEOPLASMS; CYCLIN B; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; DOWN-REGULATION; ENTEROCYTES; FLOW CYTOMETRY; G2 PHASE; GENES, RAS; HUMANS; PYRAZOLES; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SULFONAMIDES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 31144456365     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2005.11.009     Document Type: Article

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