The antiproliferative effects of somatostatin receptor subtype 2 in breast cancer cells

Acta Pharmacologica Sinica

Volumn 30, Issue 7, 2009, Pages 1053-1059

  He, Yong ^a   Yuan, Xiao Mei ^b   Lei, Ping ^b   Wu, Sha ^c   Xing, Wei ^b   Lan, Xiao Li ^a   Zhu, Hui Fen ^b   Huang, Tao ^a   Wang, Guo Bing ^a   An, Rui ^a   Zhang, Yong Xue ^a   Shen, Guan Xin ^b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Breast cancer; Epidermal growth factor receptor; Somatostatin; Somatostatin receptor

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; SOMATOSTATIN RECEPTOR 2;

APOPTOSIS; ARTICLE; BREAST CANCER; CELL CYCLE ARREST; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; RECEPTOR INTRINSIC ACTIVITY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; HUMANS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, SOMATOSTATIN; RNA, MESSENGER;

EID: 67651165238     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2009.59     Document Type: Article

References (21)

1. Watt HL, Kharmate G, Kumar U. Biology of somatostatin in breast cancer. Mol Cell Endocrinol 2008; 286: 251-61.
2. Patel YC, Srikant CB. Somatostatin receptors. Trends Endocrinol Metab 1997; 8: 398-405.
3. Buscail L, Estève JP, Saint-Laurent N, Bertrand V, Reisine T, O'Carroll AM, et al. Inhibition of cell proliferation by the somatostatin analogue RC-160 is mediated by somatostatin receptor subtypes SSTR2 and SSTR5 through different mechanisms. Proc Natl Acad Sci USA 1995; 92: 1580-4.
4. Kumar U, Grigorakis SI, Watt HL, Sasi R, Snell L, Watson P, et al. Somatostatin receptors in primary human breast cancer: quantitative analysis of mRNA for subtypes 1-5 and correlation with receptor protein expression and tumor pathology. Breast Cancer Res Treat 2005; 92: 175-86.
5. Schulz S, Helmholz T, Schmitt J, Franke K, Otto HJ, Weise W. True positive somatostatin receptor scintigraphy in primary breast cancer correlates with expression of sst2A and sst5. Breast Cancer Res Treat 2002; 72: 221-6.
6. Cameron Smith M, Orlando C, Serio M, Maggi M. Somatostatin receptors and breast cancer. J Endocrinol Invest 2003; 26: 125-30
7. 99mTc-depreotide scintigraphy. J Nucl Med 2006; 47: 6-13
8. Watt and Kumar. Colocalization of somatostatin receptors and epidermal growth factor receptors in breast cancer cells. Cancer Cell Int 2006; 6: 5
9. Reubi JC, Torhorst J. The relationship between somatostatin, epidermal growth factor, and steroid hormone receptors in breast cancer. Cancer 1989; 64: 1254-60.
10. Lacroix M, Leclercq G. Relevance of breast cancer cell lines as models for breast tumours: an update. Breast Cancer Res Treat 2004; 83: 249-89.
11. Wiseman SM, Makretsov N, Nielsen TO, Gilks B, Yorida E, Cheang M, et al. Coexpression of the type 1 growth factor receptor family members HER-1, HER-2, HER-3 has a synergistic negative prognostic effect on breast carcinoma survival. Cancer 2005; 103: 1770-7.
12. Pawlikowski M, Melen-Mucha G. Somatostatin analogs - from new molecules to new applications, Curr Opin Pharmacol 2004; 4: 608-13.
13. Susini C, Buscail L. Rationale for the use of somatostatin analogs as antitumor agents, Ann Oncol 2006; 17; 1733-42.
14. Abel F, Ejeskar K, Kogner P, Martinsson T. Gain of chromosome arm 17q is associated with unfavourable prognosis in neuroblastoma, but does not involve mutations in the somatostatin receptor 2 (SSTR2) gene at 17q24. Br J Cancer 1999; 81: 1402-9.
15. Sestini R, Orlando C, Peri A, Tricarico C, Pazzagli M, Serio M, et al. Quantitation of somatostatin receptor type 2 gene expression in neuroblastoma cell lines and primary tumors using competitive reverse transcription-polymerase chain reaction. Clin Cancer Res 1996; 2: 1757-65.
16. 99mTcdepreotide. Eur J Nucl Med Mol Imaging 2004; 31: 1022-30.
17. De Felipe P. Polycistronic viral vectors. Curr Gene Ther 2002; 2: 355-78.
18. Ballian N, Brunicardi FC, Wang XP. Somatostatin and its receptors in the development of the endocrine pancreas. Pancreas 2006; 33: 1-12.
19. YC Patel. Somatostatin and its receptor family. Frontiers Neuroendocrinol 1999; 20: 157-98.
20. Krause DS, van Etten RA. Tyrosine kinases as targets for cancer therapy. N Engl J Med 2005; 353: 172-87.
21. Schally AV, Szepeshazi K, Nagy A, Comaru-Schally AM, Halmos G. New approaches to therapy of cancers of the stomach, colon and pancreas based on peptide analogs. Cell Mol Life Sci 2004; 61: 1042-68.