MS80, a novel sulfated oligosaccharide, inhibits pulmonary fibrosis by targeting TGF-β1 both in vitro and in vivo

Acta Pharmacologica Sinica

Volumn 30, Issue 7, 2009, Pages 973-979

  Jiang, Han Dong ^a,b   Guan, Hua Shi ^a  

^a OCEAN UNIVERSITY OF CHINA   (China)

^b QINGDAO UNIVERSITY   (China)

Author keywords

Idiopathic pulmonary fibrosis; Sulfated oligosaccharide MS80; TGF 1

Indexed keywords

ANTIFIBROTIC AGENT; BLEOMYCIN; COLLAGEN; HEPARIN; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MS 80; OLIGOSACCHARIDE; PLANT EXTRACT; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CELL CYCLE REGULATION; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LUNG FIBROBLAST; LUNG FIBROSIS; NONHUMAN; PATHOGENESIS; PROTEIN FUNCTION; RAT; SEAWEED; SIGNAL TRANSDUCTION;

ANIMALS; BLEOMYCIN; BRONCHOALVEOLAR LAVAGE FLUID; CELL CYCLE; CELL PROLIFERATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MATRIX METALLOPROTEINASES; MOLECULAR STRUCTURE; OLIGOSACCHARIDES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN BINDING; PULMONARY FIBROSIS; RATS; RATS, WISTAR; SEAWEED; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 67651160533     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2009.86     Document Type: Article

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