Role of scintigraphy in inflammatory bowel disease

World Journal of Gastroenterology

Volumn 15, Issue 22, 2009, Pages 2693-2700

  Stathaki, Maria I ^a   Koukouraki, Sophia I ^a   Karkavitsas, Nikolaos S ^a   Koutroubakis, Ioannis E ^a  

^a UNIVERSITY HOSPITAL OF HERAKLION   (Greece)

Author keywords

Crohn's disease; Intestinal inflammation; Scintigraphy; Technetium 99m pentavalent dimercaptosuccinic acid; Ulcerative colitis

Indexed keywords

FLUORODEOXYGLUCOSE F 18; HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M; INDIUM 111; LEUKOCYTE IN 111; SUCCIMER TC 99M; TECHNETIUM 99M;

CELL LABELING; COLON BIOPSY; COLONOSCOPY; COMPUTER ASSISTED TOMOGRAPHY; COST UTILITY ANALYSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DISEASE ACTIVITY; DISEASE SEVERITY; EDITORIAL; ENTERITIS; GASTROINTESTINAL TRACT SCINTISCANNING; HUMAN; INTERMETHOD COMPARISON; LEUKOCYTE; NON INVASIVE MEASUREMENT; PATIENT SAFETY; POSITRON EMISSION TOMOGRAPHY; SENSITIVITY AND SPECIFICITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TUMOR LOCALIZATION;

EID: 67651159074     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.15.2693     Document Type: Editorial

References (67)

1. Hommes DW, van Deventer SJ. Endoscopy in inflammatory bowel diseases. Gastroenterology 2004; 126: 1561-1573
2. Martin-Comin J, Prats E. Clinical applications of radiolabeled blood elements in inflammatory bowel disease. Q J Nucl Med 1999; 43: 74-82
3. Nikolaus S, Schreiber S. Diagnostics of inflammatory bowel disease. Gastroenterology 2007; 133: 1670-1689
4. Albert JG, Martiny F, Krummenerl A, Stock K, Lesske J, Göbel CM, Lotterer E, Nietsch HH, Behrmann C, Fleig WE. Diagnosis of small bowel Crohn's disease: a prospective comparison of capsule endoscopy with magnetic resonance imaging and fluoroscopic enteroclysis. Gut 2005; 54: 1721-1727
5. Toms AP, Barltrop A, Freeman AH. A prospective randomised study comparing enteroclysis with small bowel follow-through examinations in 244 patients. Eur Radiol 2001; 11: 1155-1160
6. Ambrosini R, Barchiesi A, Di Mizio V, Di Terlizzi M, Leo L, Filippone A, Canalis L, Fossaceca R, Carriero A. Inflammatory chronic disease of the colon: how to image. Eur J Radiol 2007; 61: 442-448
7. Parente F, Greco S, Molteni M, Anderloni A, Bianchi Porro G. Imaging inflammatory bowel disease using bowel ultrasound. Eur J Gastroenterol Hepatol 2005; 17: 283-291
8. Horsthuis K, Bipat S, Bennink RJ, Stoker J. Inflammatory bowel disease diagnosed with US, MR, scintigraphy, and CT: meta-analysis of prospective studies. Radiology 2008; 247: 64-79
9. Madsen SM, Thomsen HS, Munkholm P, Davidsen B, Dorph S, Nielsen SL, Schlichting P. Inflammatory bowel disease evaluated by low-field magnetic resonance imaging. Comparison with endoscopy, 99mTc-HMPAO leucocyte scintigraphy, conventional radiography and surgery. Scand J Gastroenterol 2002; 37: 307-316
10. Gan SI, Beck PL. A new look at toxic megacolon: an update and review of incidence, etiology, pathogenesis, and management. Am J Gastroenterol 2003; 98: 2363-2371
11. Györke T, Duffek L, Bártfai K, Makó E, Karlinger K, Mester A, Tarján Z. The role of nuclear medicine in inflammatory bowel disease. A review with experiences of aspecific bowel activity using immunoscintigraphy with 99mTc anti-granulocyte antibodies. Eur J Radiol 2000; 35: 183-192
12. Schölmerich J, Schmidt E, Schümichen C, Billmann P, Schmidt H, Gerok W. Scintigraphic assessment of bowel involvement and disease activity in Crohn's disease using technetium 99m-hexamethyl propylene amine oxine as leukocyte label. Gastroenterology 1988; 95: 1287-1293
13. Giaffer MH, Tindale WB, Holdsworth D. Value of technetium-99m HMPAO-labelled leucocyte scintigraphy as an initial screening test in patients suspected of having inflammatory bowel disease. Eur J Gastroenterol Hepatol 1996; 8: 1195-1200
14. Weldon MJ, Lowe C, Joseph AE, Maxwell JD. Review article: quantitative leucocyte scanning in the assessment of inflammatory bowel disease activity and its response to therapy. Aliment Pharmacol Ther 1996; 10: 123-132
15. Lee BF, Chiu NT, Wu DC, Tsai KB, Liu GC, Yu HS, Wang ST. Use of 99mTc (V) DMSA scintigraphy in the detection and localization of intestinal inflammation: comparison of findings and colonoscopy and biopsy. Radiology 2001; 220: 381-385
16. Koutroubakis IE, Koukouraki SI, Dimoulios PD, Velidaki AA, Karkavitsas NS, Kouroumalis EA. Active inflammatory bowel disease: evaluation with 99mTc (V) DMSA scintigraphy. Radiology 2003; 229: 70-74
17. Stathaki MI, Koutroubakis IE, Koukouraki SI, Karmiris KP, Moschandreas JA, Kouroumalis EA, Karkavitsas NS. Active inflammatory bowel disease: head-to-head comparison between 99mTc-hexamethylpropylene amine oxime white blood cells and 99mTc(V)-dimercaptosuccinic acid scintigraphy. Nucl Med Commun 2008; 29: 27-32
18. Neurath MF, Vehling D, Schunk K, Holtmann M, Brockmann H, Helisch A, Orth T, Schreckenberger M, Galle PR, Bartenstein P. Noninvasive assessment of Crohn's disease activity: a comparison of 18F-fluorodeoxyglucose positron emission tomography, hydromagnetic resonance imaging, and granulocyte scintigraphy with labeled antibodies. Am J Gastroenterol 2002; 97: 1978-1985
19. Halpenny DF, Burke JP, Lawlor GO, O'Connell M. Role of PET and combination PET/CT in the evaluation of patients with inflammatory bowel disease. Inflamm Bowel Dis 2009.
20. Cheow HK, Voutnis DD, Evans JW, Szczepura KR, Swift EA, Bird NJ, Ruparelia P, Solanki CK, Ballinger JR, Chilvers ER, Middleton SJ, Peters AM. Quantification of disease activity in patients undergoing leucocyte scintigraphy for suspected inflammatory bowel disease. Eur J Nucl Med Mol Imaging 2005; 32: 329-337
21. Peters AM, Danpure HJ, Osman S, Hawker RJ, Henderson BL, Hodgson HJ, Kelly JD, Neirinckx RD, Lavender JP. Clinical experience with 99mTc-hexamethylpropylene-amineoxime for labelling leucocytes and imaging inflammation. Lancet 1986; 2: 946-949
22. Allan RA, Sladen GE, Bassingham S, Lazarus C, Clarke SE, Fogelman I. Comparison of simultaneous 99mTc-HMPAO and 111In oxine labelled white cell scans in the assessment of inflammatory bowel disease. Eur J Nucl Med 1993; 20: 195-200
23. Sciarretta G, Furno A, Mazzoni M, Basile C, Malaguti P. Technetium-99m hexamethyl propylene amine oxime granulocyte scintigraphy in Crohn's disease: diagnostic and clinical relevance. Gut 1993; 34: 1364-1369
24. Sans M, Fuster D, Llach J, Lomeña F, Bordas JM, Herranz R, Piqué JM, Panés J. Optimization of technetium-99m-HMPAO leukocyte scintigraphy in evaluation of active inflammatory bowel disease. Dig Dis Sci 2000; 45: 1828-1835
25. Almer S, Granerus G, Ström M, Olaison G, Bonnet J, Lémann M, Smedh K, Franzén L, Bertheau P, Cattan P, Rain JD, Modigliani R. Leukocyte scintigraphy compared to intraoperative small bowel enteroscopy and laparotomy findings in Crohn's disease. Inflamm Bowel Dis 2007; 13: 164-174
26. Kerry JE, Marshall C, Griffiths PA, Scott BB, Griffiths G. White cell scanning for inflammatory bowel disease: are biochemical markers useful referral criteria? Nucl Med Commun 2003; 24: 1145-1148
27. Alonso JC, Lopez-Longo FJ, Lampreave JL, González CM, Vegazo O, Carreño L, Almoguera I. Abdominal scintigraphy using 99mTc-HMPAO-labelled leucocytes in patients with seronegative spondylarthropathies without clinical evidence of inflammatory bowel disease. Eur J Nucl Med 1996; 23: 243-246
28. Alonso JC, Soriano A, Rubio C, Cuadra JL, Zarca M, Guerra P, Garcia A, Molino C. Technetium-99m-HMPAO-labeled leukocyte imaging in patients with seronegative spondyloarthropathies. J Nucl Med Technol 1999; 27: 204-206
29. El Maghraoui A, Dougados M, Freneaux E, Chaussade S, Amor B, Breban M. Concordance between abdominal scintigraphy using technetium-99m hexamethylpropylene amine oxime-labelled leucocytes and ileocolonoscopy in patients with spondyloarthropathies and without clinical evidence of inflammatory bowel disease. Rheumatology (Oxford) 1999; 38: 543-546
30. Biancone L, Sc opinaro F, Ierardi M, Paoluzi P, Marcheggiano A, Di Paolo MC, Porowska B, Colella AC, Pallone F. 99mTc-HMPAO granulocyte scintigraphy in the early detection of postoperative asymptomatic recurrence in Crohn's disease. Dig Dis Sci 1997; 42: 1549-1556
31. Weldon MJ, Masoomi AM, Britten AJ, Gane J, Finlayson CJ, Joseph AE, Maxwell JD. Quantification of inflammatory bowel disease activity using technetium-99m HMPAO labelled leucocyte single photon emission computerised tomography (SPECT). Gut 1995; 36: 243-250
32. Biancone L, Schillaci O, Capoccetti F, Bozzi RM, Fina D, Petruzziello C, Geremia A, Simonetti G, Pallone F. Technetium-99m-HMPAO labeled leukocyte single photon emission computerized tomography (SPECT) for assessing Crohn's disease extent and intestinal infiltration. Am J Gastroenterol 2005; 100: 344-354
33. Kolkman JJ, Falke TH, Roos JC, Van Dijk DH, Bannink IM, Den Hollander W, Cuesta MA, Peña AS, Meuwissen SG. Computed tomography and granulocyte scintigraphy in active inflammatory bowel disease. Comparison with endoscopy and operative findings. Dig Dis Sci 1996; 41: 641-650
34. Molnár T, Papós M, Gyulai C, Ambrus E, Kardos L, Nagy F, Palkó A, Pávics L, Lonovics J. Clinical value of technetium-99m-HMPAO-labeled leukocyte scintigraphy and spiral computed tomography in active Crohn's disease. Am J Gastroenterol 2001; 96: 1517-1521
35. Charron M, Di Lorenzo C, Kocoshis S. CT and 99mTc-WBC vs colonoscopy in the evaluation of inflammation and complications of inflammatory bowel diseases. J Gastroenterol 2002; 37: 23-28
36. Charron M. Technetium leukocyte imaging in inflammatory bowel disease. Curr Gastroenterol Rep 1999; 1: 245-252
37. Alberini JL, Badran A, Freneaux E, Hadji S, Kalifa G, Devaux JY, Dupont T. Technetium-99m HMPAO-labeled leukocyte imaging compared with endoscopy, ultrasonography, and contrast radiology in children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2001; 32: 278-286
38. Cucchiara S, Celentano L, de Magistris TM, Montisci A, Iula D, Fecarotta S. Colonoscopy and technetium-99m white cell scan in children with suspected inflammatory bowel disease. J Pediatr 1999; 135: 727-732
39. Charron M. Pediatric inflammatory bowel disease imaged with Tc-99m white blood cells. Clin Nucl Med 2000; 25: 708-715
40. Charron M, del Rosario FJ, Kocoshis SA. Pediatric inflammatory bowel disease: assessment with scintigraphy with 99mTc white blood cells. Radiology 1999; 212: 507-513
41. Charron M, del Rosario JF, Kocoshis S. Use of technetium-tagged white blood cells in patients with Crohn's disease and ulcerative colitis: is differential diagnosis possible? Pediatr Radiol 1998; 28: 871-877
42. Charron M, Di Lorenzo C, Kocoshis S. Are 99mTc leukocyte scintigraphy and SBFT studies useful in children suspected of having inflammatory bowel disease? Am J Gastroenterol 2000; 95: 1208-1212
43. Mojiminiyi OA, Udelsman R, Soper ND, Shepstone BJ, Dudley NE. Pentavalent Tc-99m DMSA scintigraphy. Prospective evaluation of its role in the management of patients with medullary carcinoma of the thyroid. Clin Nucl Med 1991; 16: 259-262
44. Ohta H, Endo K, Fujita T, Nakajima T, Sakahara H, Torizuka K, Shimizu Y, Hata N, Masuda H, Horiuchi K. Imaging of soft tissue tumors with Tc(V)-99m dimercaptosuccinic acid. A new tumor-seeking agent. Clin Nucl Med 1984; 9: 568-573
45. Kobayashi H, Kotoura Y, Hosono M, Sakahara H, Hosono M, Yao ZS, Tsuboyama T, Yamamuro T, Endo K, Konishi J. Diagnostic value of Tc-99m (V) DMSA for chondrogenic tumors with positive Tc-99m HMDP uptake on bone scintigraphy. Clin Nucl Med 1995; 20: 361-364
46. Banci M, Bianchi PL, Gianni W, Romani AM, De Vincentis G, Ierardi M, Scopinaro F. Preliminary evaluation of the usefulness of Tc-99m (V) DMSA in pancreatic neuroendocrine tumors. Clin Nucl Med 1996; 21: 122-124
47. Kobayashi H, Sakahara H, Hosono M, Shirato M, Endo K, Kotoura Y, Yamamuro T, Konishi J. Soft-tissue tumors: diagnosis with Tc-99m (V) dimercaptosuccinic acid scintigraphy. Radiology 1994; 190: 277-280
48. Lee BF, Chiu NT, Chang JK, Liu GC, Yu HS. Technetium-99m(V)-DMSA and gallium-67 in the assessment of bone and joint infection. J Nucl Med 1998; 39: 2128-2131
49. Ercan MT, Gülaldi NC, Unsal IS, Aydin M, Peksoy I, Hasçelik Z. Evaluation of Tc-99m(V) DMSA for imaging inflammatory lesions: an experimental study. Ann Nucl Med 1996; 10: 419-423
50. Mairal L, de Lima PA, Martin-Comin J, Baliellas C, Xiol X, Roca M, Ricart Y, Ramos M. Simultaneous administration of 111In-human immunoglobulin and 99mTc-HMPAO labelled leucocytes in inflammatory bowel disease. Eur J Nucl Med 1995; 22: 664-670
51. Delgado Castro M, Lancha C, Prats E, Mitjavilla M, Abós D, Martín-Curto LM, Crespo A, Banzo J. The diagnostic value of Tc-99m human polyclonal immunoglobulin imaging compared to Tc-99m HMPAO labeled leukocytes in inflammatory bowel disease. Clin Nucl Med 1997; 22: 17-20
52. Papos M, Nagy F, Narai G, Rajtar M, Szantai G, Lang J, Csernay L. Anti-granulocyte immunoscintigraphy and [99mTc]hexamethylpropyleneamine-oxime-labeled leukocyte scintigraphy in inflammatory bowel disease. Dig Dis Sci 1996; 41: 412-420
53. Stokkel MP, Reigman HE, Pauwels EK. Scintigraphic head-to-head comparison between 99mTc-WBCs and 99mTc-LeukoScan in the evaluation of inflammatory bowel disease: a pilot study. Eur J Nucl Med Mol Imaging 2002; 29: 251-254
54. Kapsoritakis AN, Koutroubakis IE, Kouroumalis EA, Koukouraki SI, Karkavitsas N. (99m)Tc-Leucoscan in the evaluation of inflammatory bowel disease. Eur J Nucl Med Mol Imaging 2002; 29: 1098
55. Kerry JE, Marshall C, Griffiths PA, James MW, Scott BB. Comparison between Tc-HMPAO labelled white cells and Tc LeukoScan in the investigation of inflammatory bowel disease. Nucl Med Commun 2005; 26: 245-251
56. Bruno I, Martelossi S, Geatti O, Maggiore G, Guastalla P, Povolato M, Ventura A. Antigranulocyte monoclonal antibody immunoscintigraphy in inflammatory bowel disease in children and young adolescents. Acta Paediatr 2002; 91: 1050-1055
57. Charron M, Di Lorenzo C, Kocoshis SA, Hickeson MP, Orenstein SR, Goyal A, Kahn S, Collins L. (99m)Tc antigranulocyte monoclonal antibody imaging for the detection and assessment of inflammatory bowel disease newly diagnosed by colonoscopy in children. Pediatr Radiol 2001; 31: 796-800
58. Hanna R, Braun T, Levendel A, Lomas F. Radiochemistry and biostability of autologous leucocytes labelled with 99mTc-stannous colloid in whole blood. Eur J Nucl Med 1984; 9: 216-219
59. Peacock K, Porn U, Howman-Giles R, O'Loughlin E, Uren R, Gaskin K, Dorney S, Kamath R. 99mTc-stannous colloid white cell scintigraphy in childhood inflammatory bowel disease. J Nucl Med 2004; 45: 261-265
60. Bhatti M, Chapman P, Peters M, Haskard D, Hodgson HJ. Visualising E-selectin in the detection and evaluation of inflammatory bowel disease. Gut 1998; 43: 40-47
61. Bicik I, Bauerfeind P, Breitbach T, von Schulthess GK, Fried M. Inflammatory bowel disease activity measured by positron-emission tomography. Lancet 1997; 350: 262
62. Lemberg DA, Issenman RM, Cawdron R, Green T, Mernagh J, Skehan SJ, Nahmias C, Jacobson K. Positron emission tomography in the investigation of pediatric inflammatory bowel disease. Inflamm Bowel Dis 2005; 11: 733-738
63. Löffler M, Weckesser M, Franzius C, Schober O, Zimmer KP. High diagnostic value of 18F-FDG-PET in pediatric patients with chronic inflammatory bowel disease. Ann N Y Acad Sci 2006; 1072: 379-385
64. Meisner RS, Spier BJ, Einarsson S, Roberson EN, Perlman SB, Bianco JA, Taylor AJ, Einstein M, Jaskowiak CJ, Massoth KM, Reichelderfer M. Pilot study using PET/CT as a novel, noninvasive assessment of disease activity in inflammatory bowel disease. Inflamm Bowel Dis 2007; 13: 993-1000
65. Louis E, Ancion G, Colard A, Spote V, Belaiche J, Hustinx R. Noninvasive assessment of Crohn's disease intestinal lesions with (18)F-FDG PET/CT. J Nucl Med 2007; 48: 1053-1059
66. Rubin DT, Surma BL, Gavzy SJ, Schnell KM, Bunnag AP, Huo D, Appelbaum DE. Positron emission tomography (PET) used to image subclinical inflammation associated with ulcerative colitis (UC) in remission. Inflamm Bowel Dis 2009; 15: 750-755
67. Pio BS, Byrne FR, Aranda R, Boulay G, Spicher K, Song MH, Birnbaumer L, Phelps ME, Czernin J, Silverman DH. Noninvasive quantification of bowel inflammation through positron emission tomography imaging of 2-deoxy-2-[18F]fluoro-D-glucose-labeled white blood cells. Mol Imaging Biol 2003; 5: 271-277