FoxP3+ regulatory T cells in childhood allergic rhinitis and asthma

Journal of Investigational Allergology and Clinical Immunology

Volumn 19, Issue 3, 2009, Pages 238-240

  Meszaros G ^a   Szalay, B ^a   Toldi, G ^a   Mezei, G ^a   Tamasi L ^a   Vasarhelyi B ^a   Cserhati E ^a   Treszl, Andras ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Asthma; Regulatory T cells; Severity

Indexed keywords

CD4 ANTIGEN; CD69 ANTIGEN; CD8 ANTIGEN; HLA DR ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; L SELECTIN; TRANSCRIPTION FACTOR FOXP3;

ADOLESCENT; ALLERGIC ASTHMA; ALLERGIC RHINITIS; ARTICLE; CD4 CD8 RATIO; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE SEVERITY; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRESCHOOL CHILD; REGULATORY T LYMPHOCYTE; SCHOOL CHILD;

ADOLESCENT; ASTHMA; CHILD; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; MALE; RHINITIS, ALLERGIC, PERENNIAL; RHINITIS, ALLERGIC, SEASONAL; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 67651156344     PISSN: 10189068     EISSN: 16980808     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Hawrylowicz CM, O'Garra A. Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma. Nat Rev Immunol. 2005;5:271-283 (Pubitemid 40516153)
2. Cosmi L, Liotta F, Angeli R, Mazzinghi B, Santarlasci V, Manetti R, Lasagni L, Vanini V, Romagni P, Maggi E, Annunziato F, Romagnani S. Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokines. Blood. 2004;103:3117-3121 (Pubitemid 38451689)
3. Lee JH, Yu HH, Wang LC, Yang YH, Lin YT, Chiang BL. The levels of CD4+CD25+ regulatory T cells in paediatric patients with allergic rhinitis and bronchial asthma. Clin Exp Immunol. 2006;148:53-63.
4. Xu G, Mou Z, Jiang H, Cheng L, Shi J, Xu R, Oh Y, Li H. A possible role of CD4+CD25+ T cells as well as transcription factor Foxp3 in the dysregulation of allergic rhinitis. Laryngoscope. 2007;117:876-880 (Pubitemid 46699362)
5. Zhang Q, Qian FH, Liu H, Zhou LF, Huang M, Zhang XL, Yin KS. Expression of surface markers on peripheral CD4+CD25high T cells in patients with atopic asthma: role of inhaled corticosteroid. Chin Med J (Engl). 2008;121:205-212 (Pubitemid 351234586)
6. National Asthma Education and Prevention Program. Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma-Summary Report 2007. J Allergy Clin Immunol. 2007;120:94-138.
7. Morgan ME, van Bilsen JH, Bakker AM, Heemskerk B, Schilham MW, Hartgers FC, Elferink BG, van der Zanden L, de Vries RR, Huizinga TW, Ottenhoff TH, Toes RE. Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans. Hum Immunol. 2005;66:13-20.
8. Huang JL, Ou LS, Tsao CH, Chen LC, Kuo ML. Reduced expression of CD69 and adhesion molecules of T lymphocytes in asthmatic children receiving immunotherapy. Pediatr Allergy Immunol. 2002:13:426-433