Gross lower gastrointestinal bleeding in patients on anticoagulant and/or antiplatelet therapy: Endoscopic findings, management, and clinical outcomes

Journal of Clinical Gastroenterology

Volumn 43, Issue 1, 2009, Pages 36-42

  Hashash, Jana G ^a   Shamseddeen, Wael ^a   Skoury, Assaad ^a   Aoun, Nathalie ^a   Barada, Kassem ^a  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

Anticoagulation; Antiplatelet; Gastrointestinal bleeding

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; CLOPIDOGREL; FRESH FROZEN PLASMA; LOW MOLECULAR WEIGHT HEPARIN; VITAMIN K GROUP; WARFARIN;

AGED; ARTICLE; BLOOD TRANSFUSION; CEREBROVASCULAR ACCIDENT; CLINICAL FEATURE; COLON CANCER; COLONOSCOPY; COMORBIDITY; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DEEP VEIN THROMBOSIS; DISEASE SEVERITY; DIVERTICULOSIS; FEMALE; GASTROINTESTINAL ENDOSCOPY; GASTROINTESTINAL HEMORRHAGE; HEART ATRIUM FIBRILLATION; HISTOPATHOLOGY; HOSPITALIZATION; HUMAN; HYPERCOAGULABILITY; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RESUSCITATION;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ANTICOAGULANTS; COLONOSCOPY; COMORBIDITY; DIVERTICULUM; FEMALE; GASTROINTESTINAL HEMORRHAGE; HUMANS; INTESTINE, LARGE; LENGTH OF STAY; MALE; MIDDLE AGED; PLATELET AGGREGATION INHIBITORS; RETROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX;

EID: 67651154293     PISSN: 01920790     EISSN: None     Source Type: Journal    
DOI: 10.1097/MCG.0b013e318151f9d7     Document Type: Article

References (34)

1. Johnsen SP, Sorensen HT, Mellemkjoer L, et al. Hospitalisation for upper gastrointestinal bleeding associated with use of oral anticoagulants. Thromb Haemost. 2001;86:563-568. (Pubitemid 32743267)
2. Ibanez L, Vidal X, Vendrell L, et al. Upper gastrointestinal bleeding associated with antiplatelet drugs. Aliment Pharmacol Ther. 2006;23:235-242. (Pubitemid 43382032)
3. Gitter MJ, Jaeger TM, Petterson TM, et al. Bleeding and thromboembolism during anticoagulant therapy: a populationbased study in Rochester, Minnesota. Mayo Clin Proc. 1995;70:725-733.
4. Kaplan RC, Heckbert SR, Koepsell TD, et al. Risk factors for hospitalized gastrointestinal bleeding among older persons. J Am Geriatr Soc. 2001;49:126-133. (Pubitemid 32207220)
5. Chaussade S, Desechalliers JP, Lerebours E, et al. Digestive hemorrhage under anticoagulant treatment. Retrospective analysis of a series of 178 consecutive cases. Gastroenterol Clin Biol. 1984;8:152-156.
6. Pirmohamed M, James S, Meakin S, et al. Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients. BMJ. 2004;329:15-19. (Pubitemid 38869995)
7. Wolf AT, Wasan SK, Saltzman JR. Impact of anticoagulation on rebleeding following endoscopic therapy for nonvariceal upper gastrointestinal hemorrhage. Am J Gastroenterol. 2007; 102:290-296.
8. Taha AS, Angerson WJ, Knill-Jones RP, et al. Clinical outcome in upper gastrointestinal bleeding complicating lowdose aspirin and antithrombotic drugs. Aliment Pharmacol Ther. 2006;24:633-636.
9. Thomopoulos KC, Mimidis KP, Theocharis GJ, et al. Acute upper gastrointestinal bleeding in patients on long-term oral anticoagulation therapy: endoscopic findings, clinical management and outcome. World J Gastroenterol. 2005;11: 1365-1368.
10. Lanas A, Garcia-Rodriguez LA, Arroyo MT, et al. Risk of upper gastrointestinal ulcer bleeding associated with selective COX-2 inhibitors, traditional non-aspirin NSAIDs, aspirin, and combinations. Gut. 2006;55:1731-1738.
11. Taha AS, Angerson WJ, Knill-Jones RP, et al. Upper gastrointestinal mucosal abnormalities and blood loss complicating low-dose aspirin and antithrombotic therapy. Aliment Pharmacol Ther. 2006;23:489-495. (Pubitemid 43382003)
12. Peura DA, Lanza FL, Gostout CJ, et al. The American College of Gastroenterology Bleeding Registry: preliminary findings. Am J Gastroenterol. 1997;92:924-928.
13. Strate LL. Lower GI bleeding: epidemiology and diagnosis. Gastroenterol Clin N Am. 2005;34:643-664.
14. Kollef MH, O'Brien JD, Zuckerman GR, et al. BLEED: a classification tool to predict outcomes in patients with acute upper and lower gastrointestinal hemorrhage. Crit Care Med. 1997;25:1125-1132.
15. Velayos F, Williamson A, Sousa K, et al. Early predictors of severe lower gastrointestinal bleeding and adverse outcomes: a prospective study. Clin Gastroenterol Hepatol. 2004;2: 485-490. (Pubitemid 38698364)
16. Strate LL, Orav EJ, Syngal S. Early predictors of severity in acute lower GI bleeding. Arch Int Med. 2003;163:838-843. (Pubitemid 36438056)
17. Strate LL, Syngal S. Timing of colonoscopy: impact on length of hospital stay in patients with acute lower intestinal bleeding. Am J Gastroenterol. 2003;98:317-322. (Pubitemid 36232379)
18. Al Qahtani AR, Satin R, Stern J, et al. Investigative modalities for massive lower gastrointestinal bleeding. World J Surg. 2002;26:620-625. (Pubitemid 36920378)
19. Choudari CP, Rajgopal C, Palmer KR. Acute gastrointestinal haemorrhage in anticoagulated patients: diagnoses and response to endoscopic treatment. Gut. 1994;35:464-466. (Pubitemid 24131240)
20. Rubin TA, Murdoch M, Nelson DB. Acute GI bleeding in the setting of supratherapeutic international normalized ratio in patients taking warfarin: endoscopic diagnosis, clinical management, and outcomes. Gastrointest Endosc. 2003;58:369-373. (Pubitemid 38220235)
21. Strate LL, Saltzman JR, Ookubo R, et al. Validation of a clinical prediction rule for severe acute lower intestinal bleeding. Am J Gastroenterol. 2005;100:1821-1827. (Pubitemid 41648439)
22. Rios A, Montoya MJ, Rodriguez JM, et al. Severe acute lower gastrointestinal bleeding: risk factors for morbidity and mortality. Langenbecks Arch Surg. 2007;392:165-171. (Pubitemid 46328675)
23. Schmulewitz N, Fisher DA, Rockey DC. Early colonoscopy for acute lower GI bleeding predicts shorter hospital stay: a retrospective study of experience in a single center. Gastrointest Endosc. 2003;58:841-846. (Pubitemid 37521652)
24. Das A, Ben-Menachem T, Cooper GS, et al. Prediction of outcome in acute lower-gastrointestinal haemorrhage based on an artificial neural network: internal and external validation of a predictive model. Lancet. 2003;362:1261-1266. (Pubitemid 37324252)
25. Richter JM, Christensen MR, Kaplan LM, et al. Effectiveness of current technology in the diagnosis and management of lower gastrointestinal haemorrhage. Gastrointest Endosc. 1995;41:93-98.
26. Angtuaco TL, Reddy SK, Drapkin S, et al. The utility of urgent colonoscopy in the evaluation of acute lower gastrointestinal tract bleeding: a 2-year experience from a single center. Am J Gastroenterol. 2001;96:1782-1785.
27. Longstreth GF. Epidemiology and outcome of patients hospitalized with acute lower gastrointestinal haemorrhage: a population-based study. Am J Gastroenterol. 1997;92:419-424. (Pubitemid 27108173)
28. Patel TH, Cordts PR, Abcarian P, et al. Will transcatheter embolotherapy replace surgery in the treatment of gastrointestinal bleeding? Curr Surg. 2001;58:323-327.
29. Jensen DM, Machicado GA, Jutabha R, et al. Urgent colonoscopy for the diagnosis and treatment of severe diverticular haemorrhage. N Engl J Med. 2000;342:78-82. (Pubitemid 30036598)
30. Boley SJ, DiBiase A, Brandt LJ, et al. Lower intestinal bleeding in the elderly. Am J Surg. 1979;137:57-64.
31. Leitman IM, Paull DE, Shires GT III. Evaluation and management of massive lower gastrointestinal haemorrhage. Ann Surg. 1989;209:175-180. (Pubitemid 19055318)
32. Farrell JJ, Friedman LS. Review article: the management of lower gastrointestinal bleeding. Aliment Pharmacol Ther. 2005;21: 1281-1298. (Pubitemid 40813675)
33. Conrad S. Acute upper gastrointestinal bleeding in critically ill patients: causes and treatment modalities. Crit Care Med. 2002;30(suppl):S365- S368. (Pubitemid 34620952)
34. Barkun A, Bardou M, Marshall J. Consensus recommendations for managing patients with nonvariceal upper gastrointestinal bleeding. Ann Intern Med. 2003;139:843-857.