메뉴 건너뛰기




Volumn 24, Issue 4, 2009, Pages 307-312

A new generation of antiplatelet agents

Author keywords

Acute coronary syndromes; Acute myocardial infarction; Antiplatelet agents; Aspirin; Clopidogrel; Thienopyridines; Von Willebrand factor

Indexed keywords

ABCIXIMAB; ACETYLSALICYLIC ACID; ACETYLSALICYLIC ACID 3 (NITROXYMETHYL)PHENYL ESTER; ANTITHROMBOCYTIC AGENT; ARC 1779; CANGRELOR; CLOPIDOGREL; PLACEBO; PRASUGREL; SCH 530348; TICAGRELOR; UNCLASSIFIED DRUG; P2RY12 PROTEIN, HUMAN; PURINERGIC P2 RECEPTOR; PURINERGIC P2Y12 RECEPTOR; PYRIDINE DERIVATIVE; THIENOPYRIDINE DERIVATIVE; THROMBIN RECEPTOR; TICLOPIDINE; VON WILLEBRAND FACTOR;

EID: 67651152741     PISSN: 02684705     EISSN: None     Source Type: Journal    
DOI: 10.1097/HCO.0b013e32832e2b44     Document Type: Review
Times cited : (9)

References (31)
  • 1
    • 0023805341 scopus 로고
    • Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2
    • ISIS-2 (Second International Study of Infarct Survival) Collaborative Group
    • ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. Lancet 1988; 2:349-360.
    • (1988) Lancet , vol.2 , pp. 349-360
  • 2
    • 27644548513 scopus 로고    scopus 로고
    • Addition of clopidogrel to aspirin in 45 852 patients with acute myocardial infarction: Randomised placebo-controlled trial
    • DOI 10.1016/S0140-6736(05)67660-X, PII S014067360567660X
    • Chen ZM, Jiang LX, Chen YP, et al. Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet 2005; 366:1607-1621. (Pubitemid 41552416)
    • (2005) Lancet , vol.366 , Issue.9497 , pp. 1607-1621
    • Chen, Z.1    Jiang, L.2
  • 4
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation
    • DOI 10.1056/NEJMoa010746
    • Yusuf S, Zhao F, Mehta SR, et al. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 2001; 345:494-502. (Pubitemid 32758501)
    • (2001) New England Journal of Medicine , vol.345 , Issue.7 , pp. 494-502
    • Yusuf, S.1    Zhao, F.2    Mehta, S.R.3    Chrolavicius, S.4    Tognoni, G.5    Fox, K.K.6
  • 5
    • 0037454048 scopus 로고    scopus 로고
    • Short- And long-term oral antiplatelet therapy in acute coronary syndromes and percutaneous coronary intervention
    • Mehta SR, Yusuf S. Short- and long-term oral antiplatelet therapy in acute coronary syndromes and percutaneous coronary intervention. J Am Coll Cardiol 2003; 41:79S-88S. (Pubitemid 36223351)
    • (2003) Journal of the American College of Cardiology , vol.41 , Issue.4 SUPPL. 4
    • Mehta, S.R.1    Yusuf, S.2
  • 6
    • 0037145863 scopus 로고    scopus 로고
    • Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: A randomized controlled trial
    • Steinhubl SR, Berger PB, Mann JT III, et al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA 2002; 288:2411-2420.
    • (2002) JAMA , vol.288 , pp. 2411-2420
    • Steinhubl, S.R.1    Berger, P.B.2    Mann III, J.T.3
  • 7
    • 47649116687 scopus 로고    scopus 로고
    • Pharmacology of emerging novel platelet inhibitors
    • DOI 10.1016/j.ahj.2008.06.004, PII S0002870308004717
    • Angiolillo DJ, Capranzano P. Pharmacology of emerging novel platelet inhibitors. Am Heart J 2008; 156:S10-S15. (Pubitemid 352020407)
    • (2008) American Heart Journal , vol.156 , Issue.2 SUPPL.
    • Angiolillo, D.J.1    Capranzano, P.2
  • 8
    • 0037324281 scopus 로고    scopus 로고
    • Advantages of fast-acting ADP receptor blockade in ischemic heart disease
    • DOI 10.1161/01.ATV.0000053387.06709.32
    • Nurden AT, Nurden P. Advantages of fast-acting ADP receptor blockade in ischemic heart disease. Arterioscler Thromb Vasc Biol 2003; 23:158-159. (Pubitemid 36231922)
    • (2003) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.23 , Issue.2 , pp. 158-159
    • Nurden, A.T.1    Nurden, P.2
  • 9
    • 33751572499 scopus 로고    scopus 로고
    • Clopidogrel response variability and future therapies: Clopidogrel: does one size fit all?
    • O'Donoghue M, Wiviott SD. Clopidogrel response variability and future therapies: clopidogrel: does one size fit all? Circulation 2006; 114:e600-e606.
    • (2006) Circulation , vol.114
    • O'Donoghue, M.1    Wiviott, S.D.2
  • 10
    • 10444235983 scopus 로고    scopus 로고
    • Clopidogrel resistance: A new chapter in a fastmoving story
    • Wiviott SD, Antman EM. Clopidogrel resistance: a new chapter in a fastmoving story. Circulation 2004; 109:3064-3067.
    • (2004) Circulation , vol.109 , pp. 3064-3067
    • Wiviott, S.D.1    Antman, E.M.2
  • 11
    • 46449120386 scopus 로고    scopus 로고
    • Enfermedad aterotrombótica coronaria: Avances en el tratamiento antiplaquetario
    • DOI 10.1157/13119995
    • Badimon L, Vilahur G. Coronary atherothrombotic disease: progress in antiplatelet therapy. Rev Esp Cardiol 2008; 61:501-513. (Pubitemid 351930602)
    • (2008) Revista Espanola de Cardiologia , vol.61 , Issue.5 , pp. 501-513
    • Badimon, L.1    Vilahur, G.2
  • 14
    • 47649132922 scopus 로고    scopus 로고
    • Clinical profile of prasugrel, a novel thienopyridine
    • Angiolillo DJ, Bates ER, Bass TA. Clinical profile of prasugrel, a novel thienopyridine. Am Heart J 2008; 156:S16-S22.
    • (2008) Am Heart J , vol.156
    • Angiolillo, D.J.1    Bates, E.R.2    Bass, T.A.3
  • 15
    • 21644448736 scopus 로고    scopus 로고
    • Randomized comparison of prasugrel (CS-747, LY640315), a novel thienopyridine P2Y12 antagonist, with clopidogrel in percutaneous coronary intervention: Results of the Joint Utilization of Medications to Block Platelets Optimally (JUMBO)-TIMI 26 trial
    • Wiviott SD, Antman EM, Winters KJ, et al. Randomized comparison of prasugrel (CS-747, LY640315), a novel thienopyridine P2Y12 antagonist, with clopidogrel in percutaneous coronary intervention: results of the Joint Utilization of Medications to Block Platelets Optimally (JUMBO)-TIMI 26 trial. Circulation 2005; 111:3366-3373.
    • (2005) Circulation , vol.111 , pp. 3366-3373
    • Wiviott, S.D.1    Antman, E.M.2    Winters, K.J.3
  • 18
    • 0036015034 scopus 로고    scopus 로고
    • Safety profile and tolerability of intravenous AR-C69931MX, a new antiplatelet drug, in unstable angina pectoris and non-Q-wave myocardial infarction
    • DOI 10.1016/S0149-2918(02)85149-9
    • Jacobsson F, Swahn E, Wallentin L, Ellborg M. Safety profile and tolerability of intravenous AR-C69931MX, a new antiplatelet drug, in unstable angina pectoris and non-Q-wave myocardial infarction. Clin Ther 2002; 24:752-765. (Pubitemid 34596944)
    • (2002) Clinical Therapeutics , vol.24 , Issue.5 , pp. 752-765
    • Jacobsson, F.1    Swahn, E.2    Wallentin, L.3    Dellborg, M.4
  • 19
    • 0036848824 scopus 로고    scopus 로고
    • Comparison of the pharmacodynamic effects of the platelet ADP receptor antagonists clopidogrel and AR-C69931MX in patients with ischaemic heart disease
    • DOI 10.1080/0953710021000024402
    • Storey RF, Wilcox RG, Heptinstall S. Comparison of the pharmacodynamic effects of the platelet ADP receptor antagonists clopidogrel and ARC69931MX in patients with ischaemic heart disease. Platelets 2002; 13:407-413. (Pubitemid 35346941)
    • (2002) Platelets , vol.13 , Issue.7 , pp. 407-413
    • Storey, R.F.1    Wilcox, R.G.2    Heptinstall, S.3
  • 20
    • 33344464928 scopus 로고    scopus 로고
    • Initial experience with an intravenous P2Y 12 platelet receptor antagonist in patients undergoing percutaneous coronary intervention: Results from a 2-part, phase II, multicenter, randomized, placebo- and active-controlled trial
    • Greenbaum AB, Grines CL, Bittl JA, et al. Initial experience with an intravenous P2Y 12 platelet receptor antagonist in patients undergoing percutaneous coronary intervention: results from a 2-part, phase II, multicenter, randomized, placebo- and active-controlled trial. Am Heart J 2006; 151:689.e1-689.e10.
    • (2006) Am Heart J , vol.151
    • Greenbaum, A.B.1    Grines, C.L.2    Bittl, J.A.3
  • 21
    • 0035085132 scopus 로고    scopus 로고
    • Open multicentre study of theP2T receptor antagonist AR-C69931MX assessing safety, tolerability and activity in patients with acute coronary syndromes
    • Storey RF, Oldroyd KG,Wilcox RG.Open multicentre study of theP2T receptor antagonist AR-C69931MX assessing safety, tolerability and activity in patients with acute coronary syndromes. Thromb Haemost 2001; 85:401-407.
    • (2001) Thromb Haemost , vol.85 , pp. 401-407
    • Storey, R.F.1    Oldroyd, K.G.2    Wilcox, R.G.3
  • 22
    • 33646261670 scopus 로고    scopus 로고
    • Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: A double-blind comparison to clopidogrel with aspirin
    • Husted S, Emanuelsson H, Heptinstall S, et al. Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin. Eur Heart J 2006; 27:1038-1047.
    • (2006) Eur Heart J , vol.27 , pp. 1038-1047
    • Husted, S.1    Emanuelsson, H.2    Heptinstall, S.3
  • 23
    • 35548995394 scopus 로고    scopus 로고
    • Safety, Tolerability, and Initial Efficacy of AZD6140, the First Reversible Oral Adenosine Diphosphate Receptor Antagonist, Compared with Clopidogrel, in Patients with Non-ST-Segment Elevation Acute Coronary Syndrome. Primary Results of the DISPERSE-2 Trial
    • DOI 10.1016/j.jacc.2007.07.053, PII S0735109707026344
    • Cannon CP, Husted S, Harrington RA, et al. Safety, tolerability, and initial efficacy of AZD6140, the first reversible oral adenosine diphosphate receptor antagonist, compared with clopidogrel, in patients with non-ST-segment elevation acute coronary syndrome: primary results of the DISPERSE-2 trial. J Am Coll Cardiol 2007; 50:1844-1851. (Pubitemid 350007959)
    • (2007) Journal of the American College of Cardiology , vol.50 , Issue.19 , pp. 1844-1851
    • Cannon, C.P.1    Husted, S.2    Harrington, R.A.3    Scirica, B.M.4    Emanuelsson, H.5    Peters, G.6    Storey, R.F.7
  • 25
    • 14644424575 scopus 로고    scopus 로고
    • Predictors of the rise in vWF after ST elevation myocardial infarction: Implications for treatment strategies and clinical outcome: an ENTIRE-TIMI 23 substudy
    • Ray KK, Morrow DA, Gibson CM, et al. Predictors of the rise in vWF after ST elevation myocardial infarction: implications for treatment strategies and clinical outcome: an ENTIRE-TIMI 23 substudy. Eur Heart J 2005; 26:440-446.
    • (2005) Eur Heart J , vol.26 , pp. 440-446
    • Ray, K.K.1    Morrow, D.A.2    Gibson, C.M.3
  • 26
    • 47649113839 scopus 로고    scopus 로고
    • Clinical overview of promising nonthienopyridine antiplatelet agents
    • Angiolillo DJ, Guzman LA. Clinical overview of promising nonthienopyridine antiplatelet agents. Am Heart J 2008; 156:S23-S28.
    • (2008) Am Heart J , vol.156
    • Angiolillo, D.J.1    Guzman, L.A.2
  • 27
    • 61849180442 scopus 로고    scopus 로고
    • Safety and tolerability of SCH 530348 in patients undergoing nonurgent percutaneous coronary intervention: A randomised, double-blind, placebo-controlled phase II study
    • A randomized clinical trial assessing the novel thrombin receptor antagonist in patients undergoing PCI. The trial suggested the possibility that the drug may reduce ischemic complications without increasing the rate of bleeding
    • Becker RC, Moliterno DJ, Jennings LK, et al. Safety and tolerability of SCH 530348 in patients undergoing nonurgent percutaneous coronary intervention: a randomised, double-blind, placebo-controlled phase II study. Lancet 2009; 373:919-928. A randomized clinical trial assessing the novel thrombin receptor antagonist in patients undergoing PCI. The trial suggested the possibility that the drug may reduce ischemic complications without increasing the rate of bleeding.
    • (2009) Lancet , vol.373 , pp. 919-928
    • Becker, R.C.1    Moliterno, D.J.2    Jennings, L.K.3
  • 28
    • 33845715319 scopus 로고    scopus 로고
    • Pharmacologic profile and therapeutic potential of NCX 4016, a nitric oxide-releasing aspirin, for cardiovascular disorders
    • DOI 10.1111/j.1527-3466.2006.00148.x
    • Gresele P, Momi S. Pharmacologic profile and therapeutic potential of NCX 4016, a nitric oxide-releasing aspirin, for cardiovascular disorders. Cardiovasc Drug Rev 2006; 24:148-168. (Pubitemid 46696922)
    • (2006) Cardiovascular Drug Reviews , vol.24 , Issue.2 , pp. 148-168
    • Gresele, P.1    Momi, S.2
  • 29
    • 0034699601 scopus 로고    scopus 로고
    • Nitrovasodilators, low-dose aspirin, other nonsteroidal antiinflammatory drugs, and the risk of upper gastrointestinal bleeding
    • Lanas A, Bajador E, Serrano P, et al. Nitrovasodilators, low-dose aspirin, other nonsteroidal antiinflammatory drugs, and the risk of upper gastrointestinal bleeding. N Engl J Med 2000; 343:834-839.
    • (2000) N Engl J Med , vol.343 , pp. 834-839
    • Lanas, A.1    Bajador, E.2    Serrano, P.3
  • 30
    • 0037373349 scopus 로고    scopus 로고
    • Gastrointestinal safety of NO-aspirin (NCX-4016) in healthy human volunteers: A proof of concept endoscopic study
    • DOI 10.1053/gast.2003.50096
    • Fiorucci S, Santucci L, Gresele P, et al. Gastrointestinal safety of NO-aspirin (NCX-4016) in healthy human volunteers: a proof of concept endoscopic study. Gastroenterology 2003; 124:600-607. (Pubitemid 36268478)
    • (2003) Gastroenterology , vol.124 , Issue.3 , pp. 600-607
    • Fiorucci, S.1    Santucci, L.2    Gresele, P.3    Faccino, R.M.4    Del Soldato, P.5    Morelli, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.