A commercial nutraceutical mix metabolic cell- support (MC-S™) inhibits proliferation of cancer cell lines in vitro

Australian Journal of Medical Herbalism

Volumn 21, Issue 2, 2009, Pages 39-43

  Da, Clark ^a   Mc, Adams ^b  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b UNIVERSITY OF NEWCASTLE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 67651124987     PISSN: 10338330     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Aoki T. 1984. Lentinan. In: Immune modulation agents and their mechanisms. Fenichel RL, Chirgis MA (Eds) Immunol stud 25:62-11.
2. Borchers AT, Keen CL, Gershwin ME. 2004. Mushrooms, tumors, immunity: an update. Exp Bio Med 229:5;393-406.
3. Block KI, Mead MN. 2003. Immune system effects of Echinacea, ginseng, and Astragalus: A review. Integ Can Ther 2:3;241-61.
4. Cho WC, Leung KN. 2007. In vitro and in vivo anti-tumor effects of Astragalus membranaceus. Cancer Letters 252:l;43-54.
5. Chu KK, Ho SS, Chow AH. 2002. Coriolus versicolor: a medicinal mushroom with promising immunotherapeutic values. J Clin Pharmacol 42:9;976-984.
6. Clark DA, Adams MC. 2007a. Using commercial nutraceutical mixes as immune stimulants: an in vitro proliferation study using Metabolic Cell-Support TM on non- stimulated human lymphocytes. Aust J Med Herbalism 19:3;108-11.
7. Clark DA. 2007b. An observation of a double blind placebo controlled study monitoring healthy athletes consuming a commercial preparation of nutraceuticals. Aust J Med Herbalism 19:3;112-13.
8. Dong Y, Yang MM, Kwan CY. 1997. In vitro inhibition of proliferation of HL-60 cells by tetrandrine and Coriolus versicolor peptide derived from Chinese medicinal herbs. Life Sci 60:8;135-140.
9. Fidler IJ, Ellis LM. 2000. Chemotherapeutic drugs: more really is not better. Nat Med 6:5;500-2.
10. Goa Y, Chan E, Zhou S. 2004. Immunomodulating activities of Ganoderma, a mushroom with medicinal properties. Food Rev Int 20:2;l23-61.
11. Gao Y, Gao H, Chan E et al. 2005. Antitumor activity and underlying mechanisms of Ganopoly, the refined polysaccharides extracted from Ganoderma lucidum, in mice. Immunol Invest 34:2;171-98.
12. Gibbs JB. 2000. Mechanism based target identification and drug discovery in cancer research. Sci 287:5460;1969-73.
13. Ho JW, Leung YK, Chan CP. 2002. Herbal medicine in the treatment of cancer. Curr Med Chem Anti-Cancer Agents 2:2;209-14.
14. Hobbs CH. 2000. Medicinal value of Lentinus edodes (Berk) Sing (Agaricomycetideae): a literature review. Int J Med Mushr 2:4;287-302.
15. Hong KJ, Dunn DM, Shen CL, Pence BC. 2004. Effect of Ganoderma lucidum on apoptosic and anti-infammatory function in HT-29 human colonic carcinoma cells. Phytother Res 18:9;768-70.
16. Hu H, Ahu NS, Yang X, Lee YS, Kang KS. 2002. Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human cancer cell. Int J Cancer 102:3;250-3.
17. Jiang J, Slivova V, Sliva D. 2006. Ganoderma lucidum inhibits proliferation of human breast cancer cells by down- regulation of estrogen receptor and NF-κB signaling. Int J Oncol 29:3;695-703.
18. Jiang J, Slivova V, Valachovicova T, Harvey K, Sliva D. 2004. Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC3. Int J Oncol 24:5;1093-100.
19. Kidd PM. 2000. The use of mushroom glucans and proteoglucans in cancer treatment. Altern Med Rev 5:l;4-27.
20. Lin ZB. 2005. Cellular and molecular mechanisms of immuno-modulation by Ganoderma lucidum. J Pharmacol Sci 99:2;144-53.
21. Monograph. 2003. Astragalus membranaceus. Altern Med Rev 8:l;72-7.
22. Müller CI, Kumagai T, O'Kelly J, Seeram NP, Heber D, Koeffier HP. 2006. Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myloma cells. Leuk Res 30:7;841- 8.
23. Ooi VEC, Liu F. 2000. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Curr Med Chem 7:7;715-729.
24. Pezzuto JM. 1997. Plant-derived anticancer agents. Biochem Pharmacol 53:2;121-33.
25. Sliva D. 2006. Ganoderma lucidum in cancer research. Leuk Res 30:7;767-8.
26. Sliva D, Labarrere C, Slivova V, Sedlak M, Lloyd Jr FP, Ho NWY. 2002. Ganoderma lucidum suppresses motility of highly invasive breast and prostate cancer cells. Biochem Biophys Res Commun 298:4;603-12.
27. Sliva D, Sedlak M, Slivova V, Valachovicova T, Lloyd Jr FP, Ho NWY. 2003. Biologic activity of spores and dried powder from Ganoderma lucidum for the inhibition of highly invasive human breast and prostate cancer cells. JACM 9:4,491-7.
28. Smith JE, Rowan N, Sullivan R. 2002. Medicinal mushrooms: their therapeutic properties and current medical usage with special emphasis on cancer treatments. Special report commissioned by Cancer Research U.K. http://sci.cancerreasearch.org/labs/med mush.html.
29. Stanley G, Harvey K, Slivova V, Jiaang J, Sliva D. 2005. Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-β from prostate cancer cells. Biochem Biophys Res Commun 330:l;46-52.
30. Sullivan R, Smith JE,-Rowan NJ. 2006. Medicinal mushrooms and cancer therapy translating a traditional practice into Western medicine. Perspect Biol Med 49:2; 159-70.
31. Tang W, Hemm I, Bertram. 2003. Recent development of antitumor agents from Chinese herbal medicines; part I. Low molecular compounds. Planta Med 69:2;97-108.
32. Tin MM, Cho CH, Chan K, James AE, Ko JKS. 2007. Astragalus saponins induce growth inhibition and apoptosis in human colon cancer cells and tumor xenograft. Carcinogenesis 28:6;1347-55.
33. Tzianabos AO. 2000. Polysaccaride immunomodulators as therapeutic agents: Structureal aspects and biologic function. Clin Microbiol Rev 13:4;523-33.
34. Vickers A. 2002. Botanical medicines for the treatment of cancer: rationale, overview of current data, and methodological considerations for phase I and II trials. Cancer Invest 20:7- 8;1069-79.
35. Wasser SP, Nevo E, Sokolov D, Reshetnikov SV, Timor- Tismenetsky M. 2000. Dietary supplements from medicinal mushrooms: diversity of types and variety of regulations. Int J Med Mushr2:l;1-20.
36. Xu LZ. 1999. 77;e antitumor and anti-virus activity of polysaccharopeptide (PSP), in: Yang QY (ed), Advanced Research in PSP. Hong Kong: Hong Kong Association for Health Care.
37. Yang MM, Chen ZN, Kwok JSL, Ge H. 1992. The antitumor effect of a small polypeptide from Coriolus versicolor (SPCV). Am J Clin Med 20:3-4;221-32.
38. Yang QY, Hu YJ, Li XY et al. 1993. A new biological response modifier substance - SPS, in: Yang QY, Kwok CY (eds), Proceedings of PSP International Symposium. Shanghai China: Fudan University Press.
39. Zhou S, Goa Y. 2002. The immunomodulating effects of Ganoderma lucidum (Curt Fr) P Karst. (ling Zhi, Reishi Mushroom). Int J Med Mushr 4:1; 1-11.