-
2
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34548131082
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The pathogenesis of biliary atresia: Evidence for a virus-induced autoimmune disease
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This review article focuses on the criteria necessary to define biliary atresia as an autoimmune disease and the evidence that presently exists to support this theory
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Mack CL. The pathogenesis of biliary atresia: evidence for a virus-induced autoimmune disease. Semin Liver Dis 2007; 27:233-242. This review article focuses on the criteria necessary to define biliary atresia as an autoimmune disease and the evidence that presently exists to support this theory.
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(2007)
Semin Liver Dis
, vol.27
, pp. 233-242
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Mack, C.L.1
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3
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0242413703
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Lipopolysaccharide Activates Nuclear Factor-KappaB through Toll-Like Receptors and Related Molecules in Cultured Biliary Epithelial Cells
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DOI 10.1097/01.LAB.0000097190.56734.FE
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Harada K, Ohira S, Isse K, et al. Lipopolysaccharide activates nuclear factor-kappa β through toll-like receptors and related molecules in cultured biliary epithelial cells. Lab Invest 2003; 83:1657-1667. (Pubitemid 37421106)
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(2003)
Laboratory Investigation
, vol.83
, Issue.11
, pp. 1657-1667
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Harada, K.1
Ohira, S.2
Isse, K.3
Ozaki, S.4
Zen, Y.5
Sato, Y.6
Nakanuma, Y.7
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4
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33646425856
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Lipoteichoic acid may affect the pathogenesis of bile duct damage in primary biliary cirrhosis
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DOI 10.1080/08916930600623841, PII L858040441002759
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Haruta I, Hashimoto E, Kato Y, et al. Lipoteichoic acid may affect the pathogenesis of bile duct damage in primary biliary cirrhosis. Autoimmunity 2006; 39:129-135. (Pubitemid 43675256)
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(2006)
Autoimmunity
, vol.39
, Issue.2
, pp. 129-135
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Haruta, I.1
Hashimoto, E.2
Kato, Y.3
Kikuchi, K.4
Kato, H.5
Yagi, J.6
Uchiyama, T.7
Kobayash, M.8
Shiratori, K.9
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5
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35348822432
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Biliary innate immunity and cholangiopathy
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Excellent review on the role of bile duct epithelial cells in triggering innate immunity. The authors present several experiments examining the role of endotoxin tolerance in cholangiopathies
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Harada K, Nakanuma Y. Biliary innate immunity and cholangiopathy. Hepatol Res 2007; 37:S430-S437. Excellent review on the role of bile duct epithelial cells in triggering innate immunity. The authors present several experiments examining the role of endotoxin tolerance in cholangiopathies.
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(2007)
Hepatol Res
, vol.37
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-
Harada, K.1
Nakanuma, Y.2
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6
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33645741989
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Human intrahepatic biliary epithelial cells function in innate immunity by producing IL-6 and IL-8 via the TLR4-NF-kappa β and -MAPK signaling pathways
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Yokoyama T, Komori A, Nakamura M, et al. Human intrahepatic biliary epithelial cells function in innate immunity by producing IL-6 and IL-8 via the TLR4-NF-kappa β and -MAPK signaling pathways. Liver Int 2006; 26:467-476.
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(2006)
Liver Int
, vol.26
, pp. 467-476
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Yokoyama, T.1
Komori, A.2
Nakamura, M.3
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7
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28244478101
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Multiple TLRs are expressed in human cholangiocytes and mediate host epithelial defense responses to Cryptosporidium parvum via activation of NF-kappa β
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Chen XM, O'Hara SP, Nelson JB, et al. Multiple TLRs are expressed in human cholangiocytes and mediate host epithelial defense responses to Cryptosporidium parvum via activation of NF-kappa β. J Immunol 2005; 175:7447-7456.
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(2005)
J Immunol
, vol.175
, pp. 7447-7456
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Chen, X.M.1
O'Hara, S.P.2
Nelson, J.B.3
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8
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67651128442
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Peptide antibiotic human beta-defensin-1 and -2 contribute to antimicrobial defense of the intrahepatic biliary tree
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Harada K, Ohba K, Ozaki S, et al. Peptide antibiotic human beta-defensin-1 and -2 contribute to antimicrobial defense of the intrahepatic biliary tree. Hepatology 2004; 41:506-516.
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(2004)
Hepatology
, vol.41
, pp. 506-516
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Harada, K.1
Ohba, K.2
Ozaki, S.3
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9
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14244261439
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Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts
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DOI 10.1002/hep.20582
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Isse K, Harada K, Zen Y, et al. Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts. Hepatology 2005; 41:506-516. (Pubitemid 40289497)
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(2005)
Hepatology
, vol.41
, Issue.3
, pp. 506-516
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Isse, K.1
Harada, K.2
Zen, Y.3
Kamihira, T.4
Shimoda, S.5
Harada, M.6
Nakanuma, Y.7
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10
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40949118946
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Biliary epithelial cells and primary biliary cirrhosis: The role of liver-infiltrating mononuclear cells
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This article investigates the role that BECs play in the recruitment of mononuclear cells to the liver and possible mechanisms of injury in PBC
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Shimoda S, Harada K, Niiro H, et al. Biliary epithelial cells and primary biliary cirrhosis: the role of liver-infiltrating mononuclear cells. Hepatology 2008; 47:958-965. This article investigates the role that BECs play in the recruitment of mononuclear cells to the liver and possible mechanisms of injury in PBC.
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(2008)
Hepatology
, vol.47
, pp. 958-965
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Shimoda, S.1
Harada, K.2
Niiro, H.3
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11
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34247196579
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Biliary epithelial cell antibodies link adaptive and innate immune responses in primary sclerosing cholangitis
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Outstanding study demonstrating the role of antibodies from PSC patients in inducing innate immunity
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Karrar A, Broome U, Södergern T, et al. Biliary epithelial cell antibodies link adaptive and innate immune responses in primary sclerosing cholangitis. Gastroenterology 2007; 132:1504-1514. Outstanding study demonstrating the role of antibodies from PSC patients in inducing innate immunity.
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(2007)
Gastroenterology
, vol.132
, pp. 1504-1514
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Karrar, A.1
Broome, U.2
Södergern, T.3
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12
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36349035570
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Innate immune response to double-stranded RNA in biliary epithelial cells is associated with the pathogenesis of biliary atresia
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This excellent original article demonstrates the role of TLR3 in the generation of antiviral responses and in the initiation of biliary epithelial apoptosis. The authors showed that double-stranded RNA could induce apoptosis in human biliary epithelial cells and put forth a mechanism for injury in biliary atresia
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Harada K, Sato Y, Itatsu K, et al. Innate immune response to double-stranded RNA in biliary epithelial cells is associated with the pathogenesis of biliary atresia. Hepatology 2007; 46:1146-1154. This excellent original article demonstrates the role of TLR3 in the generation of antiviral responses and in the initiation of biliary epithelial apoptosis. The authors showed that double-stranded RNA could induce apoptosis in human biliary epithelial cells and put forth a mechanism for injury in biliary atresia.
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(2007)
Hepatology
, vol.46
, pp. 1146-1154
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Harada, K.1
Sato, Y.2
Itatsu, K.3
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13
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33745046348
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Expression of the interferon-induced Mx proteins in biliary atresia
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DOI 10.1016/j.jpedsurg.2006.02.022, PII S0022346806000960
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Al-Masri AN, Flemming P, Rodeck B, et al. Expressions of the interferon-induced Mx proteins in biliary atresia. J Ped Surg 2006; 41:1139-1143. (Pubitemid 43870076)
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(2006)
Journal of Pediatric Surgery
, vol.41
, Issue.6
, pp. 1139-1143
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Al-Masri, A.N.1
Flemming, P.2
Rodeck, B.3
Melter, M.4
Leonhardt, J.5
Petersen, C.6
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14
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33845788000
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Expression of toll-like receptors and type 1 interferon specific protein MxA in biliary atesia
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Huang YH, Chou MH, Du YY, et al. Expression of toll-like receptors and type 1 interferon specific protein MxA in biliary atesia. Lab Invest 2007; 87:66-74.
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(2007)
Lab Invest
, vol.87
, pp. 66-74
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Huang, Y.H.1
Chou, M.H.2
Du, Y.Y.3
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15
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33746834534
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Increased killing activity and decreased cytokine production in NK cells in patients with primary biliary cirrhosis
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Chuang YH, Lian ZX, Tsuenyeama K, et al. Increased killing activity and decreased cytokine production in NK cells in patients with primary biliary cirrhosis. J Autoimmun 2006; 26:232-240.
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(2006)
J Autoimmun
, vol.26
, pp. 232-240
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Chuang, Y.H.1
Lian, Z.X.2
Tsuenyeama, K.3
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16
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43049181301
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Liver autoimmunity triggered by microbial activation of natural killer T cells
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The authors show that mice infected with alphaproteobacteria generate both PDC-E2 autoantibodies and T cell-mediated responses targeting bile ducts. Induction of disease required natural killer T cells. This article presents a novel mechanism involving natural killer T cells and molecular mimicry in murine PBC
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Mattner J, Savage PB, Leung P, et al. Liver autoimmunity triggered by microbial activation of natural killer T cells. Cell Host Microbe 2008; 3:304-315. The authors show that mice infected with alphaproteobacteria generate both PDC-E2 autoantibodies and T cell-mediated responses targeting bile ducts. Induction of disease required natural killer T cells. This article presents a novel mechanism involving natural killer T cells and molecular mimicry in murine PBC.
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(2008)
Cell Host Microbe
, vol.3
, pp. 304-315
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Mattner, J.1
Savage, P.B.2
Leung, P.3
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17
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39549107358
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Natural killer T cells exacerbate liver injury in a transforming growth factor b receptor II dominant negative mouse model of primary biliary cirrhosis
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This study demonstrates the essential role of natural killer T cells in a mouse model of PBC
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Chuang YH, Lian ZX, Yang GX, et al. Natural killer T cells exacerbate liver injury in a transforming growth factor b receptor II dominant negative mouse model of primary biliary cirrhosis. Hepatology 2008; 47:571-580. This study demonstrates the essential role of natural killer T cells in a mouse model of PBC.
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(2008)
Hepatology
, vol.47
, pp. 571-580
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Chuang, Y.H.1
Lian, Z.X.2
Yang, G.X.3
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18
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33846839443
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Deletion of NEMO/IKKgamma in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma
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DOI 10.1016/j.ccr.2006.12.016, PII S1535610807000207
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Luedde T, Beraza N, Kotsikoris V, et al. Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. Cancer Cell 2007; 11:119-132. (Pubitemid 46209851)
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(2007)
Cancer Cell
, vol.11
, Issue.2
, pp. 119-132
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Luedde, T.1
Beraza, N.2
Kotsikoris, V.3
Van Loo, G.4
Nenci, A.5
De Vos, R.6
Roskams, T.7
Trautwein, C.8
Pasparakis, M.9
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19
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47749136267
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IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver
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The investigators provide compelling information on the collaborative efforts of two IkB kinases to protect the biliary system from immune-mediated injury. This research is one of the most important publications within this review and implies that defects in IKK signaling may be implicated in human biliary diseases
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Luedde T, Heinrichsdorff J, deLorenzi, et al. IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver. PNAS 2008; 105:9733-9738. The investigators provide compelling information on the collaborative efforts of two IkB kinases to protect the biliary system from immune-mediated injury. This research is one of the most important publications within this review and implies that defects in IKK signaling may be implicated in human biliary diseases.
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(2008)
PNAS
, vol.105
, pp. 9733-9738
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Luedde, T.1
Heinrichsdorff, J.2
DeLorenzi3
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20
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43049094474
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a,b-deficient mice develop antimitochondrial antibodies and other features resembling primary biliary cirrhosis
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This fascinating work is aimed at determining how a deficiency in the chloridebicarbonate anion exchange transporter leads to an abnormal autoimmune response targeting biliary epithelia. This work is important in that it suggests that gene defects in anion transporters may predispose to the development of PBC
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a,b-deficient mice develop antimitochondrial antibodies and other features resembling primary biliary cirrhosis. Gastroenterology 2008; 134:1482-1493. This fascinating work is aimed at determining how a deficiency in the chloridebicarbonate anion exchange transporter leads to an abnormal autoimmune response targeting biliary epithelia. This work is important in that it suggests that gene defects in anion transporters may predispose to the development of PBC.
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(2008)
Gastroenterology
, vol.134
, pp. 1482-1493
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Salas, J.T.1
Banales, J.M.2
Sarvide, S.3
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21
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46249110385
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+ T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice
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+ T cells as the effector cells responsible for bile duct destruction
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+ T cells as the effector cells responsible for bile duct destruction.
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(2008)
Hepatology
, vol.47
, pp. 1974-1982
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Yang, G.X.1
Lian, Z.X.2
Chuang, Y.H.3
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22
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33750999089
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Cellular and humoral autoimmunity directed at bile duct epithelia in murine biliary atresia
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Mack CL, Tucker RM, Lu BR, et al. Cellular and humoral autoimmunity directed at bile duct epithelia in murine biliary atresia. Hepatology 2006; 44:1231-1239.
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(2006)
Hepatology
, vol.44
, pp. 1231-1239
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Mack, C.L.1
Tucker, R.M.2
Lu, B.R.3
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23
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34447098108
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+ lymphocytes in epithelia injury and autoimmunity in experimental biliary atresia
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This study provides further convincing evidence for bile duct-targeted autoimmune responses and the importance of CD8+ T cells as effector cells involved in cholangiocyte injury in murine biliary atresia
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+ lymphocytes in epithelia injury and autoimmunity in experimental biliary atresia. Gastroenterology 2007; 133:268-277. This study provides further convincing evidence for bile duct-targeted autoimmune responses and the importance of CD8+ T cells as effector cells involved in cholangiocyte injury in murine biliary atresia.
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(2007)
Gastroenterology
, vol.133
, pp. 268-277
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Shivakumar, P.1
Sabla, G.2
Mohanty, S.3
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24
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48449102199
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The unfinished business of primary biliary cirrhosis
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This article is an excellent review summarizing the disease course of PBC. The authors also provide an in depth look at novel pathogenic mechanisms in PBC
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Selmi C, Zuin M, Gershwin ME. The unfinished business of primary biliary cirrhosis. J Hepatol 2008; 49:451-460. This article is an excellent review summarizing the disease course of PBC. The authors also provide an in depth look at novel pathogenic mechanisms in PBC.
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(2008)
J Hepatol
, vol.49
, pp. 451-460
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Selmi, C.1
Zuin, M.2
Gershwin, M.E.3
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25
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35148835681
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Antimitochondrial antibodies of immunoglobulin G3 subclass are associated with a more severe disease course in primary biliary cirrhosis
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DOI 10.1111/j.1478-3231.2007.01586.x
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Rigopoulou E, Davies ET, Bogdanos DP, et al. Antimitochondrial antibodies of immunoglobulin G3 subclass are associated with a more severe disease course in primary biliary cirrhosis. Liver Int 2007; 27:1226-1231. (Pubitemid 47543151)
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(2007)
Liver International
, vol.27
, Issue.9
, pp. 1226-1231
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Rigopoulou, E.I.1
Davies, E.T.2
Bogdanos, D.-P.3
Liaskos, C.4
Mytilinaiou, M.5
Koukoulis, G.K.6
Dalekos, G.N.7
Vergani, D.8
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26
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33846449067
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Anti-gp210 and anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis
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DOI 10.1002/hep.21472
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Nakamura M, Kondo H, Mori T, et al. Antigp210 and anticentromere antibodies are different risk factors for the progression of primary biliary cirrhosis. Hepatology 2007; 45:118-127. (Pubitemid 46144371)
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(2007)
Hepatology
, vol.45
, Issue.1
, pp. 118-127
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Nakamura, M.1
Kondo, H.2
Mori, T.3
Komori, A.4
Matsuyama, M.5
Ito, M.6
Takii, Y.7
Koyabu, M.8
Yokoyama, T.9
Migita, K.10
Daikoku, M.11
Abiru, S.12
Yatsuhashi, H.13
Takezaki, E.14
Masaki, N.15
Sugi, K.16
Honda, K.17
Adachi, H.18
Nishi, H.19
Watanabe, Y.20
Nakamura, Y.21
Shimada, M.22
Komatsu, T.23
Saito, A.24
Saoshiro, T.25
Harada, H.26
Sodeyama, T.27
Hayashi, S.28
Masumoto, A.29
Sando, T.30
Yamamoto, T.31
Sakai, H.32
Kobayashi, M.33
Muro, T.34
Koga, M.35
Shums, Z.36
Norman, G.L.37
Ishibashi, H.38
more..
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27
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33846699177
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T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis
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DOI 10.1016/j.jaut.2006.11.004, PII S0896841106001119
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Allina J, Hu B, Sullivan DM, et al. T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis. J Autoimmun 2006; 27:232-241. (Pubitemid 46199127)
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(2006)
Journal of Autoimmunity
, vol.27
, Issue.4
, pp. 232-241
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Allina, J.1
Hu, B.2
Sullivan, D.M.3
Fiel, M.I.4
Thung, S.N.5
Bronk, S.F.6
Huebert, R.C.7
Van De Water, J.8
Larusso, N.F.9
Gershwin, M.E.10
Gores, G.J.11
Odin, J.A.12
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28
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38049120126
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Apoptosis-associated antigens recognized by autoantibodies in patients with the autoimmune liver disease primary biliary cirrhosis
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Berg CP, Stein GM, Keppler H, et al. Apoptosis-associated antigens recognized by autoantibodies in patients with the autoimmune liver disease primary biliary cirrhosis. Apoptosis 2008; 13:63-75.
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(2008)
Apoptosis
, vol.13
, pp. 63-75
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Berg, C.P.1
Stein, G.M.2
Keppler, H.3
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29
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42249116039
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Anti-CD16 autoantibodies and delayed phagocytosis of apoptotic cells in primary biliary cirrhosis
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DOI 10.1016/j.jaut.2007.10.003, PII S0896841107001199
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Allina J, Stanca CM, Garber J, et al. Anti-CD16 autoantibodies and delayed phagocytosis of apoptotic cells in primary biliary cirrhosis. J Autoimmun 2008; 30:238-245. (Pubitemid 351551504)
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(2008)
Journal of Autoimmunity
, vol.30
, Issue.4
, pp. 238-245
-
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Allina, J.1
Stanca, C.M.2
Garber, J.3
Hu, B.4
Sautes-Fridman, C.5
Bach, N.6
Odin, J.A.7
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30
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0038071684
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The unique aromatic catabolic genes in sphingomonads degrading polycyclic aromatic hydrocarbons (PAHs)
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DOI 10.2323/jgam.49.1
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Pinyakong O, Habe H, Omori T. The unique aromatic catabolic genes in sphingomonads degrading polycyclic aromatic hydrocarbons. J Gen Appl Microbiol 2003; 49:1-19. (Pubitemid 36527148)
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(2003)
Journal of General and Applied Microbiology
, vol.49
, Issue.1
, pp. 1-19
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Pinyakong, O.1
Habe, H.2
Omori, T.3
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31
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20944443874
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Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: Identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid
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Amano K, Leung PS, Rieger R, et al. Chemical xenobiotics andmitochondrial autoantigens in primary biliary cirrhosis: identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid. J Immunol 2005; 174:5874-5883. (Pubitemid 40593233)
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(2005)
Journal of Immunology
, vol.174
, Issue.9
, pp. 5874-5883
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Amano, K.1
Leung, P.S.C.2
Rieger, R.3
Quan, C.4
Wang, X.5
Marik, J.6
Suen, Y.F.7
Kurth, M.J.8
Nantz, M.H.9
Ansari, A.A.10
Lam, K.S.11
Zeniya, M.12
Matsuura, E.13
Coppel, R.L.14
Gershwin, M.E.15
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32
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33747763332
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Identification of 2-nonynoic acid, a cosmetic component, as a potential trigger of primary biliary cirrhosis
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DOI 10.1016/j.jaut.2006.06.002, PII S0896841106000461
-
Rieger R, Leung PS, Jeddeloh MR, et al. Identification of 2-nonynoic acid, a cosmetic component, as a potential trigger of primary biliary cirrhosis. J Autoimmun 2006; 27:7-16. (Pubitemid 44279362)
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(2006)
Journal of Autoimmunity
, vol.27
, Issue.1
, pp. 7-16
-
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Rieger, R.1
Leung, P.S.C.2
Jeddeloh, M.R.3
Kurth, M.J.4
Nantz, M.H.5
Lam, K.S.6
Barsky, D.7
Ansari, A.A.8
Coppel, R.L.9
Mackay, I.R.10
Gershwin, M.E.11
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33
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49649091998
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Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease
-
This research provides convincing evidence of a xenobiotic as the initiating environmental trigger to the development of autoimmune cholangitis that mimics PBC
-
Wakabyashi K, Lian ZX, Leung PSC, et al. Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease. Hepatology 2008; 48:531-540. This research provides convincing evidence of a xenobiotic as the initiating environmental trigger to the development of autoimmune cholangitis that mimics PBC.
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(2008)
Hepatology
, vol.48
, pp. 531-540
-
-
Wakabyashi, K.1
Lian, Z.X.2
Leung, P.S.C.3
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34
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67651142220
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Serum autoantibodies reactive to alpha-enolase and vimentin in murine and human biliary atresia
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Lu BR, Brindely SM, Tucker RM, et al. Serum autoantibodies reactive to alpha-enolase and vimentin in murine and human biliary atresia. Hepatology 2008; 48:412A.
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(2008)
Hepatology
, vol.48
-
-
Lu, B.R.1
Brindely, S.M.2
Tucker, R.M.3
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