메뉴 건너뛰기




Volumn 25, Issue 3, 2009, Pages 260-264

Inflammation and biliary tract injury

Author keywords

Autoimmunity; Cholangiopathy; I B kinase complex; Innate like lymphocytes

Indexed keywords

TOLL LIKE RECEPTOR;

EID: 67651123302     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOG.0b013e328325aa10     Document Type: Review
Times cited : (20)

References (34)
  • 2
    • 34548131082 scopus 로고    scopus 로고
    • The pathogenesis of biliary atresia: Evidence for a virus-induced autoimmune disease
    • This review article focuses on the criteria necessary to define biliary atresia as an autoimmune disease and the evidence that presently exists to support this theory
    • Mack CL. The pathogenesis of biliary atresia: evidence for a virus-induced autoimmune disease. Semin Liver Dis 2007; 27:233-242. This review article focuses on the criteria necessary to define biliary atresia as an autoimmune disease and the evidence that presently exists to support this theory.
    • (2007) Semin Liver Dis , vol.27 , pp. 233-242
    • Mack, C.L.1
  • 3
    • 0242413703 scopus 로고    scopus 로고
    • Lipopolysaccharide Activates Nuclear Factor-KappaB through Toll-Like Receptors and Related Molecules in Cultured Biliary Epithelial Cells
    • DOI 10.1097/01.LAB.0000097190.56734.FE
    • Harada K, Ohira S, Isse K, et al. Lipopolysaccharide activates nuclear factor-kappa β through toll-like receptors and related molecules in cultured biliary epithelial cells. Lab Invest 2003; 83:1657-1667. (Pubitemid 37421106)
    • (2003) Laboratory Investigation , vol.83 , Issue.11 , pp. 1657-1667
    • Harada, K.1    Ohira, S.2    Isse, K.3    Ozaki, S.4    Zen, Y.5    Sato, Y.6    Nakanuma, Y.7
  • 5
    • 35348822432 scopus 로고    scopus 로고
    • Biliary innate immunity and cholangiopathy
    • Excellent review on the role of bile duct epithelial cells in triggering innate immunity. The authors present several experiments examining the role of endotoxin tolerance in cholangiopathies
    • Harada K, Nakanuma Y. Biliary innate immunity and cholangiopathy. Hepatol Res 2007; 37:S430-S437. Excellent review on the role of bile duct epithelial cells in triggering innate immunity. The authors present several experiments examining the role of endotoxin tolerance in cholangiopathies.
    • (2007) Hepatol Res , vol.37
    • Harada, K.1    Nakanuma, Y.2
  • 6
    • 33645741989 scopus 로고    scopus 로고
    • Human intrahepatic biliary epithelial cells function in innate immunity by producing IL-6 and IL-8 via the TLR4-NF-kappa β and -MAPK signaling pathways
    • Yokoyama T, Komori A, Nakamura M, et al. Human intrahepatic biliary epithelial cells function in innate immunity by producing IL-6 and IL-8 via the TLR4-NF-kappa β and -MAPK signaling pathways. Liver Int 2006; 26:467-476.
    • (2006) Liver Int , vol.26 , pp. 467-476
    • Yokoyama, T.1    Komori, A.2    Nakamura, M.3
  • 7
    • 28244478101 scopus 로고    scopus 로고
    • Multiple TLRs are expressed in human cholangiocytes and mediate host epithelial defense responses to Cryptosporidium parvum via activation of NF-kappa β
    • Chen XM, O'Hara SP, Nelson JB, et al. Multiple TLRs are expressed in human cholangiocytes and mediate host epithelial defense responses to Cryptosporidium parvum via activation of NF-kappa β. J Immunol 2005; 175:7447-7456.
    • (2005) J Immunol , vol.175 , pp. 7447-7456
    • Chen, X.M.1    O'Hara, S.P.2    Nelson, J.B.3
  • 8
    • 67651128442 scopus 로고    scopus 로고
    • Peptide antibiotic human beta-defensin-1 and -2 contribute to antimicrobial defense of the intrahepatic biliary tree
    • Harada K, Ohba K, Ozaki S, et al. Peptide antibiotic human beta-defensin-1 and -2 contribute to antimicrobial defense of the intrahepatic biliary tree. Hepatology 2004; 41:506-516.
    • (2004) Hepatology , vol.41 , pp. 506-516
    • Harada, K.1    Ohba, K.2    Ozaki, S.3
  • 9
    • 14244261439 scopus 로고    scopus 로고
    • Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts
    • DOI 10.1002/hep.20582
    • Isse K, Harada K, Zen Y, et al. Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts. Hepatology 2005; 41:506-516. (Pubitemid 40289497)
    • (2005) Hepatology , vol.41 , Issue.3 , pp. 506-516
    • Isse, K.1    Harada, K.2    Zen, Y.3    Kamihira, T.4    Shimoda, S.5    Harada, M.6    Nakanuma, Y.7
  • 10
    • 40949118946 scopus 로고    scopus 로고
    • Biliary epithelial cells and primary biliary cirrhosis: The role of liver-infiltrating mononuclear cells
    • This article investigates the role that BECs play in the recruitment of mononuclear cells to the liver and possible mechanisms of injury in PBC
    • Shimoda S, Harada K, Niiro H, et al. Biliary epithelial cells and primary biliary cirrhosis: the role of liver-infiltrating mononuclear cells. Hepatology 2008; 47:958-965. This article investigates the role that BECs play in the recruitment of mononuclear cells to the liver and possible mechanisms of injury in PBC.
    • (2008) Hepatology , vol.47 , pp. 958-965
    • Shimoda, S.1    Harada, K.2    Niiro, H.3
  • 11
    • 34247196579 scopus 로고    scopus 로고
    • Biliary epithelial cell antibodies link adaptive and innate immune responses in primary sclerosing cholangitis
    • Outstanding study demonstrating the role of antibodies from PSC patients in inducing innate immunity
    • Karrar A, Broome U, Södergern T, et al. Biliary epithelial cell antibodies link adaptive and innate immune responses in primary sclerosing cholangitis. Gastroenterology 2007; 132:1504-1514. Outstanding study demonstrating the role of antibodies from PSC patients in inducing innate immunity.
    • (2007) Gastroenterology , vol.132 , pp. 1504-1514
    • Karrar, A.1    Broome, U.2    Södergern, T.3
  • 12
    • 36349035570 scopus 로고    scopus 로고
    • Innate immune response to double-stranded RNA in biliary epithelial cells is associated with the pathogenesis of biliary atresia
    • This excellent original article demonstrates the role of TLR3 in the generation of antiviral responses and in the initiation of biliary epithelial apoptosis. The authors showed that double-stranded RNA could induce apoptosis in human biliary epithelial cells and put forth a mechanism for injury in biliary atresia
    • Harada K, Sato Y, Itatsu K, et al. Innate immune response to double-stranded RNA in biliary epithelial cells is associated with the pathogenesis of biliary atresia. Hepatology 2007; 46:1146-1154. This excellent original article demonstrates the role of TLR3 in the generation of antiviral responses and in the initiation of biliary epithelial apoptosis. The authors showed that double-stranded RNA could induce apoptosis in human biliary epithelial cells and put forth a mechanism for injury in biliary atresia.
    • (2007) Hepatology , vol.46 , pp. 1146-1154
    • Harada, K.1    Sato, Y.2    Itatsu, K.3
  • 14
    • 33845788000 scopus 로고    scopus 로고
    • Expression of toll-like receptors and type 1 interferon specific protein MxA in biliary atesia
    • Huang YH, Chou MH, Du YY, et al. Expression of toll-like receptors and type 1 interferon specific protein MxA in biliary atesia. Lab Invest 2007; 87:66-74.
    • (2007) Lab Invest , vol.87 , pp. 66-74
    • Huang, Y.H.1    Chou, M.H.2    Du, Y.Y.3
  • 15
    • 33746834534 scopus 로고    scopus 로고
    • Increased killing activity and decreased cytokine production in NK cells in patients with primary biliary cirrhosis
    • Chuang YH, Lian ZX, Tsuenyeama K, et al. Increased killing activity and decreased cytokine production in NK cells in patients with primary biliary cirrhosis. J Autoimmun 2006; 26:232-240.
    • (2006) J Autoimmun , vol.26 , pp. 232-240
    • Chuang, Y.H.1    Lian, Z.X.2    Tsuenyeama, K.3
  • 16
    • 43049181301 scopus 로고    scopus 로고
    • Liver autoimmunity triggered by microbial activation of natural killer T cells
    • The authors show that mice infected with alphaproteobacteria generate both PDC-E2 autoantibodies and T cell-mediated responses targeting bile ducts. Induction of disease required natural killer T cells. This article presents a novel mechanism involving natural killer T cells and molecular mimicry in murine PBC
    • Mattner J, Savage PB, Leung P, et al. Liver autoimmunity triggered by microbial activation of natural killer T cells. Cell Host Microbe 2008; 3:304-315. The authors show that mice infected with alphaproteobacteria generate both PDC-E2 autoantibodies and T cell-mediated responses targeting bile ducts. Induction of disease required natural killer T cells. This article presents a novel mechanism involving natural killer T cells and molecular mimicry in murine PBC.
    • (2008) Cell Host Microbe , vol.3 , pp. 304-315
    • Mattner, J.1    Savage, P.B.2    Leung, P.3
  • 17
    • 39549107358 scopus 로고    scopus 로고
    • Natural killer T cells exacerbate liver injury in a transforming growth factor b receptor II dominant negative mouse model of primary biliary cirrhosis
    • This study demonstrates the essential role of natural killer T cells in a mouse model of PBC
    • Chuang YH, Lian ZX, Yang GX, et al. Natural killer T cells exacerbate liver injury in a transforming growth factor b receptor II dominant negative mouse model of primary biliary cirrhosis. Hepatology 2008; 47:571-580. This study demonstrates the essential role of natural killer T cells in a mouse model of PBC.
    • (2008) Hepatology , vol.47 , pp. 571-580
    • Chuang, Y.H.1    Lian, Z.X.2    Yang, G.X.3
  • 19
    • 47749136267 scopus 로고    scopus 로고
    • IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver
    • The investigators provide compelling information on the collaborative efforts of two IkB kinases to protect the biliary system from immune-mediated injury. This research is one of the most important publications within this review and implies that defects in IKK signaling may be implicated in human biliary diseases
    • Luedde T, Heinrichsdorff J, deLorenzi, et al. IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver. PNAS 2008; 105:9733-9738. The investigators provide compelling information on the collaborative efforts of two IkB kinases to protect the biliary system from immune-mediated injury. This research is one of the most important publications within this review and implies that defects in IKK signaling may be implicated in human biliary diseases.
    • (2008) PNAS , vol.105 , pp. 9733-9738
    • Luedde, T.1    Heinrichsdorff, J.2    DeLorenzi3
  • 20
    • 43049094474 scopus 로고    scopus 로고
    • a,b-deficient mice develop antimitochondrial antibodies and other features resembling primary biliary cirrhosis
    • This fascinating work is aimed at determining how a deficiency in the chloridebicarbonate anion exchange transporter leads to an abnormal autoimmune response targeting biliary epithelia. This work is important in that it suggests that gene defects in anion transporters may predispose to the development of PBC
    • a,b-deficient mice develop antimitochondrial antibodies and other features resembling primary biliary cirrhosis. Gastroenterology 2008; 134:1482-1493. This fascinating work is aimed at determining how a deficiency in the chloridebicarbonate anion exchange transporter leads to an abnormal autoimmune response targeting biliary epithelia. This work is important in that it suggests that gene defects in anion transporters may predispose to the development of PBC.
    • (2008) Gastroenterology , vol.134 , pp. 1482-1493
    • Salas, J.T.1    Banales, J.M.2    Sarvide, S.3
  • 21
    • 46249110385 scopus 로고    scopus 로고
    • + T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice
    • + T cells as the effector cells responsible for bile duct destruction
    • + T cells as the effector cells responsible for bile duct destruction.
    • (2008) Hepatology , vol.47 , pp. 1974-1982
    • Yang, G.X.1    Lian, Z.X.2    Chuang, Y.H.3
  • 22
    • 33750999089 scopus 로고    scopus 로고
    • Cellular and humoral autoimmunity directed at bile duct epithelia in murine biliary atresia
    • Mack CL, Tucker RM, Lu BR, et al. Cellular and humoral autoimmunity directed at bile duct epithelia in murine biliary atresia. Hepatology 2006; 44:1231-1239.
    • (2006) Hepatology , vol.44 , pp. 1231-1239
    • Mack, C.L.1    Tucker, R.M.2    Lu, B.R.3
  • 23
    • 34447098108 scopus 로고    scopus 로고
    • + lymphocytes in epithelia injury and autoimmunity in experimental biliary atresia
    • This study provides further convincing evidence for bile duct-targeted autoimmune responses and the importance of CD8+ T cells as effector cells involved in cholangiocyte injury in murine biliary atresia
    • + lymphocytes in epithelia injury and autoimmunity in experimental biliary atresia. Gastroenterology 2007; 133:268-277. This study provides further convincing evidence for bile duct-targeted autoimmune responses and the importance of CD8+ T cells as effector cells involved in cholangiocyte injury in murine biliary atresia.
    • (2007) Gastroenterology , vol.133 , pp. 268-277
    • Shivakumar, P.1    Sabla, G.2    Mohanty, S.3
  • 24
    • 48449102199 scopus 로고    scopus 로고
    • The unfinished business of primary biliary cirrhosis
    • This article is an excellent review summarizing the disease course of PBC. The authors also provide an in depth look at novel pathogenic mechanisms in PBC
    • Selmi C, Zuin M, Gershwin ME. The unfinished business of primary biliary cirrhosis. J Hepatol 2008; 49:451-460. This article is an excellent review summarizing the disease course of PBC. The authors also provide an in depth look at novel pathogenic mechanisms in PBC.
    • (2008) J Hepatol , vol.49 , pp. 451-460
    • Selmi, C.1    Zuin, M.2    Gershwin, M.E.3
  • 28
    • 38049120126 scopus 로고    scopus 로고
    • Apoptosis-associated antigens recognized by autoantibodies in patients with the autoimmune liver disease primary biliary cirrhosis
    • Berg CP, Stein GM, Keppler H, et al. Apoptosis-associated antigens recognized by autoantibodies in patients with the autoimmune liver disease primary biliary cirrhosis. Apoptosis 2008; 13:63-75.
    • (2008) Apoptosis , vol.13 , pp. 63-75
    • Berg, C.P.1    Stein, G.M.2    Keppler, H.3
  • 29
    • 42249116039 scopus 로고    scopus 로고
    • Anti-CD16 autoantibodies and delayed phagocytosis of apoptotic cells in primary biliary cirrhosis
    • DOI 10.1016/j.jaut.2007.10.003, PII S0896841107001199
    • Allina J, Stanca CM, Garber J, et al. Anti-CD16 autoantibodies and delayed phagocytosis of apoptotic cells in primary biliary cirrhosis. J Autoimmun 2008; 30:238-245. (Pubitemid 351551504)
    • (2008) Journal of Autoimmunity , vol.30 , Issue.4 , pp. 238-245
    • Allina, J.1    Stanca, C.M.2    Garber, J.3    Hu, B.4    Sautes-Fridman, C.5    Bach, N.6    Odin, J.A.7
  • 30
    • 0038071684 scopus 로고    scopus 로고
    • The unique aromatic catabolic genes in sphingomonads degrading polycyclic aromatic hydrocarbons (PAHs)
    • DOI 10.2323/jgam.49.1
    • Pinyakong O, Habe H, Omori T. The unique aromatic catabolic genes in sphingomonads degrading polycyclic aromatic hydrocarbons. J Gen Appl Microbiol 2003; 49:1-19. (Pubitemid 36527148)
    • (2003) Journal of General and Applied Microbiology , vol.49 , Issue.1 , pp. 1-19
    • Pinyakong, O.1    Habe, H.2    Omori, T.3
  • 33
    • 49649091998 scopus 로고    scopus 로고
    • Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease
    • This research provides convincing evidence of a xenobiotic as the initiating environmental trigger to the development of autoimmune cholangitis that mimics PBC
    • Wakabyashi K, Lian ZX, Leung PSC, et al. Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease. Hepatology 2008; 48:531-540. This research provides convincing evidence of a xenobiotic as the initiating environmental trigger to the development of autoimmune cholangitis that mimics PBC.
    • (2008) Hepatology , vol.48 , pp. 531-540
    • Wakabyashi, K.1    Lian, Z.X.2    Leung, P.S.C.3
  • 34
    • 67651142220 scopus 로고    scopus 로고
    • Serum autoantibodies reactive to alpha-enolase and vimentin in murine and human biliary atresia
    • Lu BR, Brindely SM, Tucker RM, et al. Serum autoantibodies reactive to alpha-enolase and vimentin in murine and human biliary atresia. Hepatology 2008; 48:412A.
    • (2008) Hepatology , vol.48
    • Lu, B.R.1    Brindely, S.M.2    Tucker, R.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.