Hyaluronan in vaginal secretions: association with recurrent vulvovaginal candidiasis

American Journal of Obstetrics and Gynecology

Volumn 201, Issue 2, 2009, Pages 206.e1-206.e5

  Lev Sagie, Ahinoam ^a   Nyirjesy, Paul ^b   Tarangelo, Nicholas ^a   Bongiovanni, Ann Marie ^a   Bayer, Cynthia ^b   Linhares, Iara M ^a,c   Giraldo, Paulo C ^d   Ledger, William J ^a   Witkin, Steven S ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

anti Candida maintenance therapy; hyaluronan; recurrent vulvovaginal candidiasis; vaginal lavage

Indexed keywords

FLUCONAZOLE; HYALURONIC ACID; INTERLEUKIN 12; INTERLEUKIN 23; INTERLEUKIN 6;

ADULT; ARTICLE; CANDIDA; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATIONAL STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNE RESPONSE; LAVAGE; MAINTENANCE THERAPY; MICROSCOPY; PRIORITY JOURNAL; RECURRENT DISEASE; SAMPLE; SYMPTOM; VAGINA CANDIDIASIS; VAGINA DISCHARGE; VAGINA SECRETION; VAGINAL BURNING SENSATION; VAGINAL PRURITUS;

EID: 67651123032     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2009.05.010     Document Type: Article

References (24)

1. Sobel J.D. Pathogenesis of recurrent vulvovaginal candidiasis. Curr Infect Dis Rep 4 (2002) 514-519
2. Witkin S.S., Jeremias J., and Ledger W.J. A localized vaginal allergic response in women with recurrent vaginitis. J Allergy Clin Immunol 81 (1988) 412-416
3. Witkin S.S., Jeremias J., and Ledger W.J. Recurrent vaginitis as a result of sexual transmission of IgE antibodies. Am J Obstet Gynecol 158 (1988) 32-36
4. Witkin S.S., Hirsch J., and Ledger W.J. A macrophage defect in women with recurrent Candida vaginitis and its reversal in vitro by prostaglandin inhibitors. Am J Obstet Gynecol 155 (1986) 790-795
5. Nawrot U., Grzybek-Hryncewicz K., Zielska U., Czarny A., and Podwinska J. The study of cell-mediated immune response in recurrent vulvovaginal candidiasis. FEMS Immunol Microbiol 29 (2000) 89-94
6. Fidel Jr. P.L. History and new insights into host defense against vaginal candidiasis. Trends Microbiol 12 (2004) 220-227
7. Babula O., Lazdane G., Kroica J., Ledger W.J., and Witkin S.S. Relation between recurrent vulvovaginal candidiasis, vaginal concentrations of mannose-binding lectin and a mannose-binding lectin gene polymorphism in Latvian women. Clin Infect Dis 37 (2003) 733-737
8. Babula O., Lazdane G., Kroica J., Linhares I.M., Ledger W.J., and Witkin S.S. Frequency of interleukin-4 (IL-4) -589 gene polymorphism and vaginal concentrations of IL-4, nitric oxide and mannose-binding lectin in women with recurrent vulvovaginal candidiasis. Clin Infect Dis 40 (2005) 1258-1262
9. Sobel J.D., Wiesenfeld H.C., Martens M., et al. Maintenance fluconazole therapy for recurrent vulvovaginal candidiasis. N Engl J Med 351 (2004) 876-883
10. Turley E.A., Noble P.W., and Bourguignon L.Y.W. Signaling properties of hyaluronan receptors. J Biol Chem 277 (2002) 4589-4592
11. + regulatory T cells. J Immunol 179 (2007) 744-747
12. Shimizu M.T., Almeida N.Q., Fantinato V., and Unterkircher C.S. Studies on hyaluronidase, chondroitin sulfatases, proteinases and phospholipase secreted by Candida species. Mycoses 39 (1996) 161-167
13. 2 production by peripheral blood mononuclear cells from healthy women and women with recurrent candidal vaginitis. J Infect Dis 164 (1991) 396-399
14. Witkin S.S., Jeremias J., and Ledger W.J. A localized vaginal allergic response in women with recurrent vaginitis. J Allergy Clin Immunol 81 (1988) 412-416
15. Rigg D., Miller M.M., and Metzger W.J. Recurrent allergic vulvovaginitis: treatment with Candida albicans allergen immunotherapy. Am J Obstet Gynecol 162 (1990) 332-336
16. Moraes P.S.A. Recurrent vaginal candidiasis and allergic rhinitis: a common association. Ann Allergy Asthma Immunol 81 (1998) 165-169
17. Donders G.G.G., Babula O., Bellen G., Linhares I.M., and Witkin S.S. Mannose-binding lectin gene polymorphism and resistance to therapy in women wit recurrent vulvovaginal candidiasis. BJOG 115 (2008) 1225-1231
18. Sakai A., Akifusa S., Itano N., et al. Potential role of high molecular weight hyaluronan in the anti-Candida activity of human oral epithelial cells. Med Mycol 45 (2007) 73-79
19. Yano J., Lilly E.A., Steele C., Fortenberry D., and Fidel Jr. P.L. Oral and vaginal epithelial cell anti-Candida activity is acid labile and does not require live epithelial cells. Oral Microbiol Immunol 20 (2005) 199-205
20. Steele C., Leigh J.E., Swoboda R.K., Ozenci H., and Fidel Jr. P.L. Potential role for a carbohydrate moiety in anti-Candida activity of human oral epithelial cells. Infect Immunol 69 (2001) 7091-7099
21. Pirnazar P., Wolinsky L., Nachnani S., Haake S., Pilloni A., and Bernard G.W. Bacteriostatic effects of hyaluronic acid. J Periodontol 70 (1999) 370-374
22. Papanicolaou D.A., Wilder R.L., Manolagas S.C., and Chrousos G.P. The pathophysiologic roles of interleukin-6 in human disease. Ann Intern Med 128 (1998) 127-137
23. Oppmann B., Lesley R., Blom B., et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13 (2000) 715-725
24. Acosta-Rodriguez E.V., Rivino L., Geginat J., et al. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol 8 (2007) 639-646