Growth Hormone-Induced Increases in Skeletal Muscle Mass Alleviates the Associated Insulin Resistance in Short Children Born Small for Gestational Age, but Not with Growth Hormone Deficiency

Hormone Research

Volumn 72, Issue 1, 2009, Pages 38-45

  Martin, David D ^a   Schweizer, Roland ^a   Schönau, Eckhard ^b   Binder, Gerhard ^a   Ranke, Michael B ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

C peptide; Fat mass; Growth hormone; Insulin sensitivity; Insulin like growth factor 1; Muscle mass; Peripheral quantitative computed tomography

Indexed keywords

C PEPTIDE; GLUCOSE; GROWTH HORMONE; INSULIN; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ARTICLE; BODY COMPOSITION; BODY FAT; BODY HEIGHT; CHILD; CONTROLLED STUDY; DRUG MECHANISM; EVENING DOSAGE; FEMALE; FOREARM; GLUCOSE BLOOD LEVEL; GROWTH HORMONE DEFICIENCY; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; MUSCLE MASS; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SCHOOL CHILD; SKELETAL MUSCLE; SMALL FOR DATE INFANT;

BODY COMPOSITION; C-PEPTIDE; CHILD; GROWTH DISORDERS; HUMAN GROWTH HORMONE; HUMANS; INFANT, NEWBORN; INFANT, SMALL FOR GESTATIONAL AGE; INSULIN RESISTANCE; MUSCLE, SKELETAL;

EID: 67651115683     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000224339     Document Type: Article

References (29)

1. Arends NJ, Boonstra VH, Duivenvoorden HJ, Hofman PL, Cutfield WS, Hokken-Koelega AC: Reduced insulin sensitivity and the presence of cardiovascular risk factors in short prepubertal children born small for gestational age. Clin Endocrinol (Oxf) 2005;62:44-50.
2. Hofman PL, Cutfield WS, Robinson EM, Bergman RN, Menon RK, Sperling MA, Gluckman PD: Insulin resistance in short children with intrauterine growth retardation. J Clin Endocrinol Metab 1997;82:402-406.
3. Hokken-Koelega AC, De Waal WJ, Sas TC, Van Pareren Y, Arends NJ: Small for gestational age: endocrine and metabolic consequences and effects of growth hormone treatment. J Pediatr Endocrinol Metab 2004;17(suppl):463-469.
4. Leger J, Levy-Marchal C, Bloch J, Pinet A, Chevenne D, Porquet D, Collin D, Czernichow P: Reduced final height and indications for insulin resistance in 20-year-olds born small for gestational age: regional cohort study. BMJ 1997;315:341-347.
5. Soto N, Bazaes RA, Pena V, Salazar T, Avila A, Iniguez G, Ong KK, Dunger DB, Mericq MV: Insulin sensitivity and secretion are related to catch-up growth in small-for-gesta-tional-age infants at age 1 year: results from a prospective cohort. J Clin Endocrinol Metab 2003;88:3645-3650.
6. Wallace TM, Levy JC, Matthews DR: Use and abuse of HOMA modeling. Diabetes Care 2004;27:1487-1495.
7. Soman V, Tamborlane W, DeFronzo R, Genel M, Felig P: Insulin binding and insulin sensitivity in isolated growth hormone deficiency. N Engl J Med 1978;299:1025-1030.
8. Cutfield WS, Jackson WE, Jefferies C, Robinson EM, Breier BH, Richards GE, Hofman PL: Reduced insulin sensitivity during growth hormone therapy for short children born small for gestational age. J Pediatr 2003;142:113-116.
9. De Zegher F, Ong K, van Helvoirt M, Mohn A, Woods K, Dunger D: High-dose growth hormone (GH) treatment in non-GH-deficient children born small for gestational age induces growth responses related to pre-treatment GH secretion and associated with a reversible decrease in insulin sensitivity. J Clin Endocrinol Metab 2002;87:148-151.
10. Reinehr T, Kiess W, Kapellen T, Andler W: Insulin sensitivity among obese children and adolescents, according to degree of weight loss. Pediatrics 2004;115:1569-1573.
11. Yakar S, Setser J, Zhao H, Stannard B, Haluzik M, Glatt V, Bouxsein ML, Kopchick JJ, LeRoith D: Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice. J Clin Invest 2004;113:96-105.
12. Schweizer R, Martin DD, Schwarze CP, Binder G, Georgiadou A, Ihle J, Ranke MB: Cortical bone density is normal in prepubertal children with growth hormone (GH) deficiency, but initially decreases during GH replacement due to early bone remodeling. J Clin Endocrinol Metab 2003;89:5266-5272.
13. Schweizer R, Traunecker R, Ranke MB: Methoden zur Evaluierung des Knochens;Bildgebende Verfahren;in Ranke MB, Schönau E (eds): Wachstumsstörungen im Kindes-und Jugendalter aus der Perspektive des Knochens. Zwickau, Verlag Wissen-schaftliche Scripten, 2004, pp 35-43.
14. Schoenau E: Problems of bone analysis in childhood and adolescence. Pediatr Nephrol 1998;12:420-429.
15. Schoenau E, Neu CM, Beck B, Manz F, Rauch F: Bone mineral content per muscle cross-sectional area as an index of the functional muscle-bone unit. J Bone Miner Res 2002;17:1095-1101.
16. Hauffa BP, Lehmann N, Bettendorf M, Mehls O, Dorr HG, Partsch CJ, Schwarz HP, Stahnke N, Steinkamp H, Said E, Sander S, Ranke MB: Central reassessment of GH concentrations measured at local treatment centers in children with impaired growth: consequences for patient management. Eur J Endocrinol 2004;150:291-297.
17. Blum WF, Albertsson-Wikland K, Rosberg S, Ranke MB: Serum levels of insulin-like growth factor I (IGF-I) and IGF binding protein 3 reflect spontaneous growth hormone secretion. J Clin Endocrinol Metab 1993;76:1610-1616.
18. Prader A, Largo RH, Molinari L, Issler C: Physical growth of Swiss children from birth to 20 years of age. First Zürich longitudinal study of growth and development. Helv Paediatr Acta Suppl 1989;52:1-125.
19. Cole TJ, Freeman J V, Preece MA: Body mass index reference curves for the UK, 1990. Arch Dis Child 1995;73:25-29.
20. Niklasson A, Ericson A, Fryer JG, Karlberg J, Lawrence C, Karlberg P: An update of the Swedish reference standards for weight, length and head circumference at birth for given gestational age (1977-1981). Acta Paediatr Scand 1991;80:756-762.
21. Hew FL, Koschmann M, Christopher M, Rantzau C, Vaag A, Ward G, Beck-Nielsen H, Alford F: Insulin resistance in growth hormone-deficient adults: defects in glucose utilization and glycogen synthase activity. J Clin Endocrinol Metab 1996;81:555-564.
22. Rizza RA, Mandarino LJ, Gerich JE: Effects of growth hormone on insulin action in man. Mechanisms of insulin resistance, impaired suppression of glucose production, and impaired stimulation of glucose utilization. Diabetes 1982;31:663-669.
23. Chawla A, Repa JJ, Evans RM, Mangelsdorf DJ: Nuclear receptors and lipid physiology: opening the X-files. Science 2001;294:1866-1870.
24. Laron Z, Avitzur Y, Klinger B: Insulin resistance in Laron syndrome. Primary insulinlike growth factor-I (IGF-I) deficiency and effect of IGF-I replacement therapy. J Pediatr Endocrinol Metabol 1997;10(suppl 1):105-115.
25. Woods KA, van Helvoirt M, Ong KKL, Mohn A, Levy JC, de Zegher F, Dunger DB: The somatotropic axis in short children born small for gestational age: relation to insulin resistance. Pediatr Res 2002;51:76-80.
26. Cousin SP, Hügl SR, Myers MG Jr, White MF, Reifel-Miller A, Rhodes CJ: Stimulation of pancreatic β-cell proliferation by growth hormone is glucose-dependent: signal transduction via Janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling. Biochem J 1999;344:649-658.
27. Boonstra VH, Arends NJ, Stijnen T, Blum WF, Akkerman O, Hokken-Koelega AC: Food intake of children with short stature born small for gestational age before and during a randomized GH trial. Horm Res 2006;65:23-30.
28. Cutfield WS, Jefferies CA, Jackson WE, Robinson EM, Hofman PL: Evaluation of HOMA and QUICKI as measures of insulin sensitivity in prepubertal children. Pediatr Diabetes 2003;4:119-125.
29. Gungor N, Saad R, Janosky J, Arslanian S: Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents. J Pediatr 2004;144:47-55.