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Bochud PY, Chien JW, Marr KA, et al. Toll-like receptor 4 polymorphisms and aspergillosis instem-celltransplantation. N EnglJ Med 2008;359:1766-1777. This study examined the role of TLR polymorphisms in post-HSCT invasive aspergillosis. A SNP in the donor TLR4 gene was associated with a significant independent risk of invasive aspergillosis. By examining two separate (discovery and validation) cohorts, the authors were able to reduce the likelihood that these observations were population-specific.
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Mezger M, Steffens M, Beyer M, et al. Polymorphisms in the chemokine (C-X-C motif) ligand 10 are associated with invasive aspergillosis after allogeneic stem-cell transplantation and influence CXCL10 expression in monocyte-derived dendritic cells. Blood 2008; 111:534-536. This study identified an association between SNPs in the CXCL-10 gene and invasive aspergillosis in HSCT recipients. Furthermore, there was reduced expression of CXCL-10 following stimulation with Aspergillus fumigatus germlings in immature dendritic cells carrying these SNPs.
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