Diagnosis and management of pediatric endocrine neoplasms

Current Opinion in Pediatrics

Volumn 21, Issue 3, 2009, Pages 379-385

  Iqbal, Corey W ^a   Wahoff, David C ^b,c  

^a MAYO CLINIC   (United States)

^b CHILDREN S HOSPITALS AND CLINICS OF MINNESOTA   (United States)

^c Mayo Clinic   (United States)

Author keywords

Adrenal; Carcinoid; Parathyroid; Pediatric; Thyroid

Indexed keywords

(3 IODOBENZYL)GUANIDINE I 131; MITOTANE; PARATHYROID HORMONE;

ADOLESCENT; ADRENAL CORTEX CARCINOMA; ADRENAL TUMOR; ASPIRATION BIOPSY; CANCER SURGERY; CARCINOID SYNDROME; CHILDHOOD CANCER; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DEXAMETHASONE SUPPRESSION TEST; DIFFERENTIAL DIAGNOSIS; DNA DETERMINATION; ECHOGRAPHY; ENDOCRINE TUMOR; GENE MUTATION; HORMONE DETERMINATION; HUMAN; MULTIPLE ENDOCRINE NEOPLASIA; NUCLEAR MAGNETIC RESONANCE IMAGING; PARAGANGLIOMA; PARATHYROID ADENOMA; PARATHYROIDECTOMY; PHEOCHROMOCYTOMA; PRIMARY HYPERPARATHYROIDISM; PRIORITY JOURNAL; PROGNOSIS; REVIEW; THYROID CANCER; THYROID FUNCTION TEST; THYROIDECTOMY;

ADOLESCENT; CHILD; COMBINED MODALITY THERAPY; DIAGNOSIS, DIFFERENTIAL; ENDOCRINE GLAND NEOPLASMS; HUMANS; MORBIDITY; PROGNOSIS; SURVIVAL RATE; UNITED STATES;

EID: 67651113972     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOP.0b013e32832b335e     Document Type: Review

References (75)

1. Rallison ML, Dobyns BM, Keating FR Jr, et al. Thyroid nodularity in children. JAMA 1975; 233:1069-1072.
2. Josefson J, Zimmerman D. Thyroid nodules in children. Pediatr Endocrinol Rev 2008; 6:14-23. This study offers a thorough review of thyroid nodules in children.
3. Al-Shaikh A, Ngan B, Daneman A, et al. Fine-needle aspiration in the management of thyroid nodules in children and adolescents. Pediatrics 2001; 138:140-142. (Pubitemid 32097160)
4. Gharib H. Fine-needle aspiration biopsy of thyroid nodules: advantages, limitations, and effect. Mayo Clin Proc 1994; 69:44-49. (Pubitemid 24016915)
5. Hung W, Anderson KD, Chandra RS, et al. Solitary thyroid nodules in 71 children and adolescents. J Pediatr Surg 1992; 27:1407-1409.
6. Desjardins JG, Khan A, Montupet P, et al. Management of thyroid nodules in children: a 20-year experience. J Pediatr Surg 1987; 22:736-739. (Pubitemid 17154717)
7. Puligandla P. The Canadian Pediatric Thyroid Nodule Study: an evaluation of current management practices. J Pediatr Surg 2008; 43:826-830. This is a multicenter assessment of current practices in the evaluation and management of thyroid nodules in children. It highlights the importance of evidence-based guidelines.
8. Skinner MA, Safford SD. Endocrine disorders and tumors. In: Ashcraft KW, Holcomb III GW, Murphy JP, editors. Pediatric surgery. Philadelphia, Pennsylvania: Elsevier Saunders; 2005. pp. 1088-1104.
9. Yip FW, Reeve TS, Poole AG, et al. Thyroid nodules in childhood and adolescence. Aust N Z J Surg 1994; 64:676-678.
10. Danko ME, Skinner MA. Surgical intervention in children with multiple endocrine neoplasia type 2. Curr Opin Pediatr 2006; 18:312-315. (Pubitemid 43832710)
11. Roman S, Mehta P, Sosa JA. Medullary thyroid cancer: early detection and novel treatments. Curr Opin Oncol 2008; 21:5-10. This review focuses on the utility of RET protooncogene analysis and calcitonin in the work-up of MTC.
12. Castellone MD, Santoro M. Dysregulated RET signaling in thyroid cancer. Endocrinol Metab Clin N Am 2008; 37:363-374. This review focuses on the RET protooncogene. (Pubitemid 351698089)
13. Corrias S, Einaudi E, Chiorboli G, et al. Accuracy of fine needle aspiration biopsy of thyroid nodules in detecting malignancy in childhood: comparison with conventional clinical, laboratory, and imaging approaches. J Clin Endocrinol Metab 2001; 86:4644-4648.
14. De Luca F, Chaussain JL, Job JC. Hyperfunctioning thyroid nodules in children and adolescents. Acta Pediatr 2008; 75:118-123. This is a case series of hyperfunctioning thyroid nodules in children and adolescents.
15. Grigsby PW, Gal-or A, Michalski JM, et al. Childhood and adolescent thyroid carcinoma. Cancer 2002; 95:724-729.
16. Raab SS, Silverman JF, Elsheikh TM, et al. Pediatric thyroid nodules: disease demographics and clinical management as determined by fine needle aspiration biopsy. Pediatrics 1995; 95:46-49.
17. Mazzaferri EL. Management of solitary thyroid nodule. New Engl J Med 1993; 328:553-559.
18. Lugo-Vincente H, Ortiz VN, Irizarry H, et al. Pediatric thyroid nodules: management in the era of fine needle aspiration. J Pediatr Surg 1998; 33:1302-1305. (Pubitemid 28384824)
19. Amrikachi M, Ponder TB, Wheeler TM, et al. Thyroid fine-needle aspiration biopsy in children and adolescents: experience with 218 aspirates. Diagn Cytopathol 2005; 32:189-192. (Pubitemid 40397325)
20. Zenaty D, Aigrain Y, Peuchmaur M, et al. Medullary thyroid carcinoma identified within the first year of life in children with multiple endocrine neoplasia type 2A (codon 634) and 2B. Eur J Endocrinol 2009. [Epub ahead of print] This small series of patients supports early thyroidectomy in MEN 2A and B patients.
21. Telander RL, Zimmerman D, van Heerden JA, et al. Results of thyroidectomy for medullary thyroid carcinoma in children with multiple endocrine neoplasia type 2. J Pediatr Surg 1986; 21:1190-1194. (Pubitemid 17187917)
22. Haveman JW, van Tol KM, Rouwe CW, et al. Surgical experience with differentiated thyroid carcinoma. Ann Surg Oncol 2003; 10:15-20.
23. Kuo SF, Chao TC, Chang HY, et al. The role of radioactive iodine therapy in young patients with papillary thyroid cancer. Clin Nucl Med 2009; 34:4-6. This is a retrospective review with follow-up of 11 years that demonstrates the efficacy of I-131 in young patients with papillary thyroid cancer.
24. Saint-Vil D, Emran MA, Lambert R, et al. Cumulative doses of adjunct 131I treatment depend on location of residual thyroid tissue after total thyroidectomy in differentiated thyroid cancer. J Pediatr Surg 2007; 42:853-856. This retrospective review has more modest follow-up and fewer patients compared with Kuo et al.'s [23••] follow-up with inconclusive results. (Pubitemid 46719224)
25. Palmer BA, Zarroug AE, Poley RN, et al. Papillary thyroid carcinoma in children: risk factors and complications of disease recurrence. J Pediatr Surg 2005; 40:1284-1288. (Pubitemid 41096154)
26. Thompson GB, Hay ID. Current strategies for surgical management and adjuvant treatment of childhood papillary thyroid carcinoma. World J Surg 2004; 28:1187-1198.
27. Stockigt JR. Ambiguous thyroglobulin assay results in the follow-up of differentiated thyroid carcinoma. J Clin Endocrinol Metab 2005; 90:5904-5905. (Pubitemid 41415510)
28. Harness JK, Thompson NW, McLeod MK, et al. Differentiated thyroid carcinoma in children and adolescents. World J Surg 1992; 16:547-554.
29. Zimmerman D, Hay ID, Gough IR, et al. Papillary thyroid carcinoma in children and adults: long-term follow-up of 1039 patients conservatively treated at one institution during three decades. Surgery 1988; 104:1157-1166. (Pubitemid 19012000)
30. La Quaglia MP, Corbally MT, Heller G, et al. Recurrence and morbidity in differentiated thyroid carcinoma in children. Surgery 1988; 104:1149-1156. (Pubitemid 19011999)
31. Schlumberger M, De Vathaire F, Travagli JP, et al. Differentiated thyroid carcinoma in childhood: long term follow-up of 72 patients. J Clin Endocrinol Metab 1987; 65:1088-1094. (Pubitemid 18026839)
32. Bhattachryya N. A population-base analysis of survival factors in differentiated and medullary thyroid carcinoma. Otolaryngol Head Neck Surg 2003; 128:115-123. (Pubitemid 36246129)
33. Cupisti K, Wolf A, Raffel A, et al. Long-term clinical and biochemical follow-up in medullary thyroid carcinoma: a single institution's experience over 20 years. Ann Surg 2007; 246:815-821. A robust series of patients with MTC with extended follow-up that highlights prognostic factors and survival statistics. (Pubitemid 350035658)
34. Kollars J, Zarroug AE, van Heerden J, et al. Primary hyperparathyroidism in pediatric patients. Pediatrics 2005; 115:974-980.
35. Harman CR, van Heerden J, Farley DR, et al. Sporadic primary hyperparathyroidism in young patients. Arch Surg 1999; 134:651-656.
36. Chesney RW. Primary hyperparathyroidism in pediatric patients: clear-cut differences from adult patients. Pediatrics 2005; 115:1073.
37. Jacobson SR, van Heerden J, Farley DR, et al. Focused cervical exploration for primary hyperparathyroidism without intraoperative parathyroid hormone monitoring or use of the gamma probe. World J Surg 2004; 28:1127-1131.
38. Sosa JA, Tuggle CT, Wang TS, et al. Clinical and economic outcomes of thyroid and parathyroid surgery in children. J Clin Endocrinol Metab 2008; 93:3058-3065. This study reviews outcomes of thyroid and parathyroid surgery in children using a national inpatient database and highlights the outcome differences between low and high-volume centers.
39. Seehofer D, Rayes N, Ulrich F, et al. Intraoperative measurement of intact parathyroid hormone in renal hyperparathyroidism by an inexpensive routine assay. Langenbeck's Arch Surg 2001; 386:440-443. (Pubitemid 33140752)
40. Buxo-Diaz JA, Geissinger WT, Walker PJ, et al. Total parathyroidectomy and autotransplantation. Clin Nephrol 1981; 16:276-282.
41. Liou LS, Kay R. Adrenocortical carcinoma in children: review and recent innovations. Urol Clin N Am 2000; 27:403-421. (Pubitemid 30655700)
42. Barry MK, van Heerden J, Farley DR, et al. Can adrenal incidentalomas be safely observed? World J Surg 1998; 22:599-603.
43. McNicol AM. A diagnostic approach to adrenal cortical lesions. Endocr Pathol 2008; 19:241-251.
44. Boland GW, Blake MA, Hahn PF, et al. Incidental adrenal lesions: principles, techniques, and algorithms for imaging characterization. Radiology 2008; 249:756-775. This review highlights the radiologic features that help distinguish different types of adrenal lesions.
45. Mayer SK, Oligny LL, Deal C, et al. Childhood adrenocortical tumors: case series and reevaluation of prognosis: a 24-year experience. J Pediatr Surg 1997; 32:911-915. (Pubitemid 27264058)
46. Teinturie C, Pauchard MS, Brugieres L, et al. Clinical and prognostic aspects of adrenocortical neoplasms in childhood. Med Pediatr Oncol 1999; 32:106-111. (Pubitemid 29053007)
47. Hanna AM, Pham TH, Askegard-Giesman JR, et al. Outcome of adrenocortical tumors in children. J Pediatr Surg 2008; 43:843-849. This is a retrospective review that highlights features and outcomes of adrenocortical tumors in children.
48. Sabbaga CC, Avilla SG, Schulz C, et al. Adrenocortical carcinoma in children: clinical aspects and prognosis. J Pediatr Surg 1993; 28:841-843. (Pubitemid 23176047)
49. Huang H, Fojo T. Adjuvant mitotane for adrenocortical cancer: a recurring controversy. J Clin Endocrinol Metab 2008; 93:3730-3732. This study addresses the pros and cons of mitotane in the management of ACC.
50. Ostuni JA, Roginsky MS. Metastatic adrenal cortical carcinoma: documented cure with combined chemotherapy. Arch Intern Med 1975; 135:1257-1258.
51. Eriksson B, Oberg K, Curstedt T, et al. Treatment of hormone-producing adrenocortical cancer with o,p'DDD and streptozocin. Cancer 1987; 59:1398-1403. (Pubitemid 17044992)
52. LeFevre M, Gerard-Marchant R, Gubler JP. Adrenal cortical carcinoma in children: 42 patients treated 1958-1980 at Villejuif. In: Humphrey GB, Grindey GB, Dehner LP, editors. Adrenal and endocrine tumors in children. Boston, Massachusetts: Martinus Nijhoff; 1983.
53. Stewart DR, Jones PH, Jolleys A. Carcinoma of the adrenal gland in children. J Pediatr Surg 1974; 9:59-67.
54. Magiakou MA, Mastorakos G, Oldfield EH, et al. Cushing's syndrome in children and adolescents: presentation, diagnosis, and therapy. New Engl J Med 1994; 331:629-636. (Pubitemid 24276862)
55. Batista DL, Riar J, Keil M, et al. Diagnostic tests for children who are referred for the investigation of Cushing Syndrome. Pediatrics 2007; 120:e575-e586. This study suggests that the work-up of Cushing syndrome can be simplified to include a single cortisol level at midnight followed by a high-dose dexamethasone suppression test. (Pubitemid 47358270)
56. Van Wyk JJ, Ritzen EM. The role of bilateral adrenalectomy in the treatment of congenital adrenal hyperplasia. J Clin Endocrinol Metab 2003; 88:2993-2998. (Pubitemid 36877460)
57. Ilias I, Torpy DJ, Pacak K, et al. Cushing's syndrome due to ectopic corticotropin secretion: twenty years' experience at the National Institutes of Health. J Clin Endocrinol Metab 2005; 90:4955-4962. (Pubitemid 41159396)
58. Abasiyanik A, Oran B, Kaymakci A, et al. Conn syndrome in a child, caused by adrenal adenoma. J Pediatr Surg 1996; 31:430-432. (Pubitemid 26104902)
59. Pham TH, Moir CR, Thompson GB, et al. Pheochromocytoma and paraganglioma in children: a review of medical and surgical management at a tertiary care center. Pediatrics 2006; 118:1109-1117.
60. Caty MG, Coran AG, Gaegen M, et al. Current diagnosis and treatment of pheochromocytoma in children. Experience with 22 consecutive tumors in 14 patients. Arch Surg 1990; 125:978-981.
61. Ross JH. Pheochromocytoma: special considerations in children. Urol Clin N Am 2000; 27:393-402.
62. Tekautz TM, Pratt CB, Jenkins JJ, et al. Pediatric extraadrenal paraganglioma. J Pediatr Surg 2003; 38:1317-1321.
63. Kudva YC, Sawka AM, Young WF Jr. The laboratory diagnosis of adrenal pheochromocytoma: the Mayo Clinic experience. J Clin Endocrinol Metab 2003; 88:4533-4539.
64. Albanese CT, Wiener ES. Routine total bilateral adrenalectomy is not warranted in childhood familial pheochromocytoma. J Pediatr Surg 1993; 28:1248-1252.
65. Neumann HPH, Bender BU, Reincke M, et al. Adrenal-sparing surgery for pheochromocytoma. Br J Surg 1999; 86:94-97.
66. Stinner B, Kisker O, Zielke A, et al. Surgical management for carcinoid tumors of small bowel, appendix, colon, and rectum. World J Surg 1996; 20:183-188. (Pubitemid 26069484)
67. Turner MC, Lieberman E, DeQuattro V. The perioperative management of pheochromocytoma in children. Clin Pediatr (Phila) 1993; 31:583-589.
68. Safford SD, Coleman RE, Gockerman JP, et al. Iodine-131 metaiodobenzylguanidine is an effective treatment for malignant pheochromocytoma and paraganglioma. Surgery 2003; 134:956-963.
69. Sisson JC, Shapiro B, Shulkin BL, et al. Treatment of malignant pheochromocytomas with 131-I metaiodobenzylguanidine and chemotherapy. Am J Clin Oncol 1999; 22:364-370. (Pubitemid 30257634)
70. Spunt SL, Pratt CB, Rao BN, et al. Childhood carcinoid tumors: the St. Jude Children's Research Hospital Experience. J Pediatr Surg 2000; 35:1282-1286. (Pubitemid 30677779)
71. Dall'Inga P, Ferrari A, Luzzatto C, et al. Carcinoid tumor of the appendix in childhood: the experience of two Italian institutions. J Pediatr Gastroenterol Nutr 2005; 40:216-219. (Pubitemid 40269745)
72. Parkes SE, Muir KR, Al Sheyyab M, et al. Carcinoid tumors of the appendix in children 1957-1986: incidence, treatment and outcome. Br J Surg 1993; 80:502-504.
73. Doede T, Foss HD, Waldschmidt J. Carcinoid tumors of the appendix in children: epidemiology, clinical aspects and procedure. Eur J Pediatr Surg 2000; 10:372-377. (Pubitemid 32118805)
74. Wang LT, Wilkins EW, Bode HH. Bronchial carcinoid tumors in pediatric patients. Chest 1993; 103:1426-1428. (Pubitemid 23145596)
75. Hancock BJ, Di Lorenzo M, Youssef S, et al. Childhood primary pulmonary neoplasms. J Pediatr Surg 1993; 28:133-136.