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Volumn 21, Issue 1, 2009, Pages 5-10

Medullary thyroid cancer: Early detection and novel treatments

Author keywords

Calcitonin screening; Medullary thyroid cancer; Novel chemotherapy

Indexed keywords

ANTINEOPLASTIC AGENT; CALCITONIN; FLUORODEOXYGLUCOSE F 18; PENTETATE INDIUM IN 111; UNCLASSIFIED DRUG; VANDETANIB; XL 184;

EID: 58149239805     PISSN: 10408746     EISSN: None     Source Type: Journal    
DOI: 10.1097/CCO.0b013e32831ba0b3     Document Type: Review
Times cited : (47)

References (41)
  • 1
    • 45149088749 scopus 로고    scopus 로고
    • Calcitonin measurement in the evaluation of thyroid nodules in the United States: A cost-effectiveness and decision analysis
    • This novel study analyzes the cost-effectiveness of routine basal calcitonin screening in the United States using a decision model for a hypothetical group of adult patients presenting for evaluation of thyroid nodules in the United States
    • Cheung KC, Roman SA, Wang TS, et al. Calcitonin measurement in the evaluation of thyroid nodules in the United States: a cost-effectiveness and decision analysis. J Clin Endocrinol Metab 2008; 93:2173-2180. This novel study analyzes the cost-effectiveness of routine basal calcitonin screening in the United States using a decision model for a hypothetical group of adult patients presenting for evaluation of thyroid nodules in the United States.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 2173-2180
    • Cheung, K.C.1    Roman, S.A.2    Wang, T.S.3
  • 2
    • 84924637584 scopus 로고
    • Medullary (solid) carcinoma of the thyroid; a clinicopathologic entity
    • Hazard JB, Crile G Jr. Medullary (solid) carcinoma of the thyroid; a clinicopathologic entity. J Clin Endocrinol Metab 1959; 19:152-161.
    • (1959) J Clin Endocrinol Metab , vol.19 , pp. 152-161
    • Hazard, J.B.1    Crile Jr, G.2
  • 3
    • 0001251788 scopus 로고
    • The association of pheochromocytoma with carcinoma of the thyroid gland
    • Sippel J. The association of pheochromocytoma with carcinoma of the thyroid gland. Am J Med 1961; 31:163-166.
    • (1961) Am J Med , vol.31 , pp. 163-166
    • Sippel, J.1
  • 4
    • 0013886997 scopus 로고
    • Histogenesis of medullary carcinoma of the thyroid
    • Williams E. Histogenesis of medullary carcinoma of the thyroid. J Clin Pathol 1966; 19:114-118.
    • (1966) J Clin Pathol , vol.19 , pp. 114-118
    • Williams, E.1
  • 5
    • 0025231330 scopus 로고
    • Incidence of sporadic and familial medullary thyroid carcinoma in Sweden 1959 through 1981. A nationwide study in 126 patients
    • Bergholm U, Telenius-Berg M, Johansson H, et al. Incidence of sporadic and familial medullary thyroid carcinoma in Sweden 1959 through 1981. A nationwide study in 126 patients. Acta Oncol 1990; 29:9-15.
    • (1990) Acta Oncol , vol.29 , pp. 9-15
    • Bergholm, U.1    Telenius-Berg, M.2    Johansson, H.3
  • 6
    • 0027400538 scopus 로고
    • Medullary carcinoma of the thyroid with carcinoidlike features
    • Harach HR, Bergholm U. Medullary carcinoma of the thyroid with carcinoidlike features. J Clin Pathol 1993; 46:113-117.
    • (1993) J Clin Pathol , vol.46 , pp. 113-117
    • Harach, H.R.1    Bergholm, U.2
  • 7
    • 33750509391 scopus 로고    scopus 로고
    • Prognosis of medullary thyroid carcinoma
    • Roman SA, Lin R, Sosa JA. Prognosis of medullary thyroid carcinoma. Cancer 2006; 107:2134-2142.
    • (2006) Cancer , vol.107 , pp. 2134-2142
    • Roman, S.A.1    Lin, R.2    Sosa, J.A.3
  • 8
    • 33845420535 scopus 로고    scopus 로고
    • Current approaches to medullary thyroid carcinoma, sporadic and familial
    • Fialkowski EA, Moley JF. Current approaches to medullary thyroid carcinoma, sporadic and familial. J Surg Oncol 2006; 94:737-747.
    • (2006) J Surg Oncol , vol.94 , pp. 737-747
    • Fialkowski, E.A.1    Moley, J.F.2
  • 9
    • 34748833963 scopus 로고    scopus 로고
    • New directions in the treatment of thyroid cancer
    • You YN, Lakhani V, Wells SA. New directions in the treatment of thyroid cancer. J Am Coll Surg 2007; 205 (4 Suppl 1):S45-S48.
    • (2007) J Am Coll Surg , vol.205 , Issue.4 SUPPL. 1
    • You, Y.N.1    Lakhani, V.2    Wells, S.A.3
  • 11
    • 36849056630 scopus 로고    scopus 로고
    • RET genetic screening in patients with medullary thyroid cancer and their relatives: Experience with 807 individuals at one center
    • This study assesses the role of RET genetic screening in identifying hereditary forms of medullary thyroid cancer frequently misdiagnosed as sporadic thyroid cancer
    • Elisei R, Romei C, Cosci B, et al. RET genetic screening in patients with medullary thyroid cancer and their relatives: experience with 807 individuals at one center. J Clin Endocrinol Metab 2007; 92:4725-4729. This study assesses the role of RET genetic screening in identifying hereditary forms of medullary thyroid cancer frequently misdiagnosed as sporadic thyroid cancer.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 4725-4729
    • Elisei, R.1    Romei, C.2    Cosci, B.3
  • 12
    • 0141940150 scopus 로고    scopus 로고
    • Early malignant progression of hereditary medullary thyroid cancer
    • Machens A, Niccoli-Sire P, Hoegel J, et al. Early malignant progression of hereditary medullary thyroid cancer. N Engl J Med 2003; 349:1517-1525.
    • (2003) N Engl J Med , vol.349 , pp. 1517-1525
    • Machens, A.1    Niccoli-Sire, P.2    Hoegel, J.3
  • 13
    • 34547191205 scopus 로고    scopus 로고
    • Medullary thyroid cancer: Monitoring and therapy
    • Ball DW. Medullary thyroid cancer: monitoring and therapy. Endocrinol Metab Clin North Am 2007; 36:823-837.
    • (2007) Endocrinol Metab Clin North Am , vol.36 , pp. 823-837
    • Ball, D.W.1
  • 14
    • 45749139320 scopus 로고    scopus 로고
    • Current management of medullary thyroid cancer
    • Sippel RS, Kunnimalaiyaan M, Chen H. Current management of medullary thyroid cancer. Oncologist 2008; 13:539-547.
    • (2008) Oncologist , vol.13 , pp. 539-547
    • Sippel, R.S.1    Kunnimalaiyaan, M.2    Chen, H.3
  • 16
    • 0030378003 scopus 로고    scopus 로고
    • Early presentation of metastatic medullary carcinoma in multiple endocrine neoplasia, type HA: Implications for therapy
    • Gill JR, Reyes-Mugica M, lyengar S, et al. Early presentation of metastatic medullary carcinoma in multiple endocrine neoplasia, type HA: implications for therapy. J Pediatr 1996; 129:459-464.
    • (1996) J Pediatr , vol.129 , pp. 459-464
    • Gill, J.R.1    Reyes-Mugica, M.2    lyengar, S.3
  • 17
    • 0036330820 scopus 로고    scopus 로고
    • Prophylactic thyroidectomy in MEN 2A syndrome: Experience in a single center
    • Rodriguez Gonzalez JM, Balsalobre MD, Pomares F, et al. Prophylactic thyroidectomy in MEN 2A syndrome: experience in a single center. J Am Coll Surg 2002; 195:159-166.
    • (2002) J Am Coll Surg , vol.195 , pp. 159-166
    • Rodriguez Gonzalez, J.M.1    Balsalobre, M.D.2    Pomares, F.3
  • 18
    • 18444380535 scopus 로고    scopus 로고
    • Familial medullary thyroid carcinoma: Clinical variability and low aggressiveness associated with ret mutation at codon 804
    • Lombardo F, Baudin E, Chiefari E, et al. Familial medullary thyroid carcinoma: clinical variability and low aggressiveness associated with ret mutation at codon 804. J Clin Endocrinol Metab 2002; 87:1674-1680.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1674-1680
    • Lombardo, F.1    Baudin, E.2    Chiefari, E.3
  • 19
    • 0028174024 scopus 로고
    • A mutation in the RET protooncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma
    • Hofstra RMW, Landsvater RM, Ceccherini I, et al. A mutation in the RET protooncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma. Nature 1994; 367:375-376.
    • (1994) Nature , vol.367 , pp. 375-376
    • Hofstra, R.M.W.1    Landsvater, R.M.2    Ceccherini, I.3
  • 20
    • 0028033474 scopus 로고
    • RET proto-oncogene mutations in inherited and sporadic medullary thyroid cancer
    • Blaugrund JE, Johns MM, Eby YJ, et al. RET proto-oncogene mutations in inherited and sporadic medullary thyroid cancer. Hum Mol Genet 1994; 3:1895-1897.
    • (1994) Hum Mol Genet , vol.3 , pp. 1895-1897
    • Blaugrund, J.E.1    Johns, M.M.2    Eby, Y.J.3
  • 21
    • 10744223544 scopus 로고    scopus 로고
    • Impact of routine measurement of serum calcitonin on the diagnosis and outcome of medullary thyroid cancer: Experience in 10864 patients with nodular thyroid disorders
    • Elisei R, Bottici V, Luchetti F, et al. Impact of routine measurement of serum calcitonin on the diagnosis and outcome of medullary thyroid cancer: experience in 10864 patients with nodular thyroid disorders. J Clin Endocrinol 2004; 89:163.
    • (2004) J Clin Endocrinol , vol.89 , pp. 163
    • Elisei, R.1    Bottici, V.2    Luchetti, F.3
  • 22
    • 50649083690 scopus 로고    scopus 로고
    • Medullary thyroid carcinoma without marked elevation of calcitonin: A diagnostic and surveillance dilemma
    • This case report and review of literature presents a patient with calcitonin-negative MTC and discusses the methods of postoperative surveillance for this subset of patients
    • Wang TS, Ocal IT, Sosa JA, et al. Medullary thyroid carcinoma without marked elevation of calcitonin: A diagnostic and surveillance dilemma. Thyroid 2008; 18:889-894. This case report and review of literature presents a patient with calcitonin-negative MTC and discusses the methods of postoperative surveillance for this subset of patients.
    • (2008) Thyroid , vol.18 , pp. 889-894
    • Wang, T.S.1    Ocal, I.T.2    Sosa, J.A.3
  • 23
    • 0033773089 scopus 로고    scopus 로고
    • Normal preoperative calcitonin levels do not always exclude medullary thyroid carcinoma in patients with large palpable thyroid masses
    • Redding AH, Levine SN, Fowler MR. Normal preoperative calcitonin levels do not always exclude medullary thyroid carcinoma in patients with large palpable thyroid masses. Thyroid 2000; 10:919-922.
    • (2000) Thyroid , vol.10 , pp. 919-922
    • Redding, A.H.1    Levine, S.N.2    Fowler, M.R.3
  • 24
    • 3042781310 scopus 로고    scopus 로고
    • Lack of elevated serum carcinoembryonic antigen and calcitonin in medullary thyroid carcinoma
    • Bockhorn M, Frilling A, Rewerk S. Lack of elevated serum carcinoembryonic antigen and calcitonin in medullary thyroid carcinoma. Thyroid 2004; 14:468-470.
    • (2004) Thyroid , vol.14 , pp. 468-470
    • Bockhorn, M.1    Frilling, A.2    Rewerk, S.3
  • 25
    • 0036691183 scopus 로고    scopus 로고
    • Can sporadic medullary thyroid carcinoma be biochemically predicted? Prospective analysis of 66 operated patients with elevated serum calcitonin levels
    • lacobone M, Niccoli-Sire P, Sebag F, et al. Can sporadic medullary thyroid carcinoma be biochemically predicted? Prospective analysis of 66 operated patients with elevated serum calcitonin levels. World J Surg 2002; 26:886-890.
    • (2002) World J Surg , vol.26 , pp. 886-890
    • lacobone, M.1    Niccoli-Sire, P.2    Sebag, F.3
  • 26
    • 0032756813 scopus 로고    scopus 로고
    • Is medullary thyroid cancer predictable? A prospective study of 86 patients with abnormal pentagastrin tests
    • Scheuba C, Kaserer K, Weinhausl A, et al. Is medullary thyroid cancer predictable? A prospective study of 86 patients with abnormal pentagastrin tests. Surgery (St Louis) 1999; 126:1089-1095.
    • (1999) Surgery (St Louis) , vol.126 , pp. 1089-1095
    • Scheuba, C.1    Kaserer, K.2    Weinhausl, A.3
  • 27
    • 36549040883 scopus 로고    scopus 로고
    • Medullary thyroid microcarcinoma recommendations for treatment: A single-center experience
    • This study interprets biochemical and pathohistological findings of patients with smMTC (≤10 mm) and makes recommendations regarding lymph node surgery in this subset of patients
    • Scheuba C, Kaserer K, Beiglmayer C, et al. Medullary thyroid microcarcinoma recommendations for treatment: a single-center experience. Surgery 2007; 142:1003-1010. This study interprets biochemical and pathohistological findings of patients with smMTC (≤10 mm) and makes recommendations regarding lymph node surgery in this subset of patients.
    • (2007) Surgery , vol.142 , pp. 1003-1010
    • Scheuba, C.1    Kaserer, K.2    Beiglmayer, C.3
  • 28
    • 38349068615 scopus 로고    scopus 로고
    • Reference range of serum calcitonin levels in humans: Influence of calcitonin assays, sex, age, and cigarette smoking
    • d'Herbomez M, Caron P, Bauters C, et al. Reference range of serum calcitonin levels in humans: influence of calcitonin assays, sex, age, and cigarette smoking. Eur J Endocrinol 2007; 157:749.
    • (2007) Eur J Endocrinol , vol.157 , pp. 749
    • d'Herbomez, M.1    Caron, P.2    Bauters, C.3
  • 29
    • 22044449732 scopus 로고    scopus 로고
    • Preoperative diagnosis of medullary thyroid carcinoma: Fine needle aspiration cytology as compared with serum calcitonin measurement
    • Bugalho MJM, Santos JR, Sobrinho L. Preoperative diagnosis of medullary thyroid carcinoma: fine needle aspiration cytology as compared with serum calcitonin measurement. J Surg Oncol 2005; 91:56-60.
    • (2005) J Surg Oncol , vol.91 , pp. 56-60
    • Bugalho, M.J.M.1    Santos, J.R.2    Sobrinho, L.3
  • 31
    • 23944492638 scopus 로고    scopus 로고
    • Central neck dissection in the management of sporadic medullary thyroid microcarcinoma
    • Hamy A, Pessaux P, Mirallie E, et al. Central neck dissection in the management of sporadic medullary thyroid microcarcinoma. Eur J Surg Oncol 2005; 31:774.
    • (2005) Eur J Surg Oncol , vol.31 , pp. 774
    • Hamy, A.1    Pessaux, P.2    Mirallie, E.3
  • 32
    • 17844400055 scopus 로고    scopus 로고
    • Prospects of remission in medullary thyroid carcinoma according to basal calcitonin level
    • Machens A, Schneyer U, Holzhausen H-J, Dralle H. Prospects of remission in medullary thyroid carcinoma according to basal calcitonin level. J Clin Endocrinol Metab 2005; 90:2029-2034.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 2029-2034
    • Machens, A.1    Schneyer, U.2    Holzhausen, H.-J.3    Dralle, H.4
  • 33
    • 34247142774 scopus 로고    scopus 로고
    • Natural history, diagnosis, treatment and outcome of medullary thyroid cancer: 37 years experience on 157 patients
    • Pelizzo MR, Boschin IM, Bemante P, et al. Natural history, diagnosis, treatment and outcome of medullary thyroid cancer: 37 years experience on 157 patients. Eur J Surg Oncol 2007; 33:493-497.
    • (2007) Eur J Surg Oncol , vol.33 , pp. 493-497
    • Pelizzo, M.R.1    Boschin, I.M.2    Bemante, P.3
  • 34
    • 29144512280 scopus 로고    scopus 로고
    • Contralateral cervical and mediastinal lymph node metastasis in medullary thyroid cancer: Systemic disease?
    • Machens A, Holzhausen H-J, Dralle H. Contralateral cervical and mediastinal lymph node metastasis in medullary thyroid cancer: systemic disease? Surgery 2006; 139:28-32.
    • (2006) Surgery , vol.139 , pp. 28-32
    • Machens, A.1    Holzhausen, H.-J.2    Dralle, H.3
  • 35
    • 34247120095 scopus 로고    scopus 로고
    • Thyroid cancer invasion of neck structures: Epidemiology, evaluation, staging and management
    • Morton RP, Ahmad Z. Thyroid cancer invasion of neck structures: epidemiology, evaluation, staging and management. Curr Opin Otolaryngol Head Neck Surg 2007; 15:89-94.
    • (2007) Curr Opin Otolaryngol Head Neck Surg , vol.15 , pp. 89-94
    • Morton, R.P.1    Ahmad, Z.2
  • 36
    • 0031929995 scopus 로고    scopus 로고
    • Carcinoid metastases to the liver: Role of triple-phase helical CT
    • Paulson EK, McDermott VG, Keogan MT, et al. Carcinoid metastases to the liver: role of triple-phase helical CT. Radiology 1998; 206:143-150.
    • (1998) Radiology , vol.206 , pp. 143-150
    • Paulson, E.K.1    McDermott, V.G.2    Keogan, M.T.3
  • 37
    • 41949099184 scopus 로고    scopus 로고
    • The role of 18F-FDG PET/CT in detecting metastatic deposits of recurrent medullary thyroid carcinoma: A prospective study
    • 18F-FDG PET/CT performed with a hybrid tomography in detecting recurrent medullary thyroid carcinoma
    • 18F-FDG PET/CT performed with a hybrid tomography in detecting recurrent medullary thyroid carcinoma.
    • (2008) Eur J Surg Oncol , vol.34 , pp. 581-586
    • Rubello, D.1    Rampin, L.2    Nanni, C.3
  • 38
    • 34248594179 scopus 로고    scopus 로고
    • Diagnostic accuracy of 18F-FDG PET in restaging patients with medullary thyroid carcinoma and elevated calcitonin levels
    • Ong SC, Schoder H, Patel SG, et al. Diagnostic accuracy of 18F-FDG PET in restaging patients with medullary thyroid carcinoma and elevated calcitonin levels. J Nucl Med 2007; 48:501-507.
    • (2007) J Nucl Med , vol.48 , pp. 501-507
    • Ong, S.C.1    Schoder, H.2    Patel, S.G.3
  • 39
    • 35948994121 scopus 로고    scopus 로고
    • Imaging medullary thyroid carcinoma with persistent elevated calcitonin levels
    • Giraudet AL, Vanel D, Leboulleux S, et al. Imaging medullary thyroid carcinoma with persistent elevated calcitonin levels. J Clin Endocrinol Metab 2007; 92:4185-4190.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 4185-4190
    • Giraudet, A.L.1    Vanel, D.2    Leboulleux, S.3
  • 40
    • 58149233577 scopus 로고    scopus 로고
    • Wells SA, Gosnell JE, Gagel RF, Moley JF, et al. Vandetanib in metastatic hereditary medullary thyroid cancer: follow-up results of an open-label phase II trial. J Clin Oncol 2007; 25:6018. This open-label phase II trial of vandetanib assesses the objective tumor response (RECIST criteria measured every 3 months), including disease control rate, biochemical response, safety, and tolerability.
    • Wells SA, Gosnell JE, Gagel RF, Moley JF, et al. Vandetanib in metastatic hereditary medullary thyroid cancer: follow-up results of an open-label phase II trial. J Clin Oncol 2007; 25:6018. This open-label phase II trial of vandetanib assesses the objective tumor response (RECIST criteria measured every 3 months), including disease control rate, biochemical response, safety, and tolerability.
  • 41
    • 36549021634 scopus 로고    scopus 로고
    • A phase I dose-escalation study of the safety and pharmacokinetics (PK) of XL184, a VEGFR and MET kinase inhibitor, administered orally to patients (pts) with advanced malignancies
    • Salgia R, Hong DS, Camacho LH, et al. A phase I dose-escalation study of the safety and pharmacokinetics (PK) of XL184, a VEGFR and MET kinase inhibitor, administered orally to patients (pts) with advanced malignancies. J Clin Oncol 2007; 25 (18 Suppl):14031.
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL. , pp. 14031
    • Salgia, R.1    Hong, D.S.2    Camacho, L.H.3


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