'Novel alkyl side chain sulfone 1α,25-dihydroxyvitamin D3 analogs: A comparison of in vitro antiproliferative activities and in vivo calcemic activities'

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 15, 2009, Pages 5627-5631

  Usera, Aimee R ^a   Dolan, Patrick ^b   Kensler, Thomas W ^b   Posner, Gary H ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

1 ,25 Dihydroxyvitamin D3; Antiproliferative; Calcitriol; Sulfone; Trifluoromethyl

Indexed keywords

CALCITRIOL; CALCITRIOL DERIVATIVE; CALCIUM ION; DIMETHYL SULFONE; ISOPROPYLSULFONE; SULFONE DERIVATIVE; TERT BUTYLSULFONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CALCIUM MOBILIZATION; CALCIUM URINE LEVEL; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SYNTHESIS; KERATINOCYTE; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CALCITRIOL; CALCIUM; CELL PROLIFERATION; CELLS, CULTURED; KERATINOCYTES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES; VITAMIN D; VITAMINS;

EID: 67651099040     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.06.033     Document Type: Article

References (17)

1. Okamura W.H., and Zhu G. Vitamin D (1997), Academic Press, San Diego
2. Vieth R. Bone Miner. 11 (1990) 267
3. Holick M.F. Vitamin D: Molecular Biology, Physiology, and Clinical Applications (1999), Humana Press, Totowa
4. Feldman D., Glorieux F., and Pike J.W. Vitamin D (1997), Academic Press, San Diego
5. 3 Analogs. In: Feldman D., Glorieux F., and Pike J.W. (Eds). Vitamin D. 2nd ed. (2003), Academic Press, San Diego
6. Posner G.H. J. Nutr. 132 (2002) 3802S
7. Bouillon R., Okamura W.H., and Norman A.W. Endocr. Rev. 16 (1995) 200
8. Usera A.R., Dolan P.M., Kensler T.W., and Posner G.H. Bioorg. Med. Chem. 15 (2007) 5509
9. Maienfisch P., and Hall R.G. Chimia 58 (2004) 93
10. Kirsch P. Modern Fluoroorganic Chemistry. Synthesis, Reactivity, Applications (2004), Wiley-VCH, Weinheim
11. Chambers R.D. Fluorine in Organic Chemistry (2004), Blackwell Publishing, Oxford p 1-7
12. Uneyama K. Organofluorine Chemistry (2006), Blackwell Publishing, Oxford p 6-15, 81-82, 173-180, 206-215
13. Yamada S., Shimizu M., and Yamamoto K. Med. Res. Rev. 23 (2003) 89
14. deGraaf C., Vermeulen N.P.E., and Feenstra K.A. J. Med. Chem. 48 (2005) 2725
15. Posner G.H., Wang Q., Han G., Lee J.K., Crawford K., Zans S., Brem H., Peleg S., Dolan P., and Kensler T.W. J. Med. Chem. 42 (1999) 3425
16. Dai H., and Posner G.H. Synthesis (1994) 1383
17. Posner G.H., Lee J.K., White M.C., Hutchings R.H., Dai H., Kachinski J.L., Dolan P., and Kensler T.W. J. Org. Chem. 62 (1997) 3299