Antiproliferative, low-calcemic, fluorinated sulfone analogs of 1α,25-dihydroxyvitamin D3: Chemical synthesis and biological evaluation

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 16, 2007, Pages 5509-5518

  Usera, Aimee R ^a   Dolan, Patrick M ^b   Kensler, Thomas W ^b   Posner, Gary H ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Calcitriol; Fluorinated sulfones; Trifluoromethyl; Vitamin D3

Indexed keywords

ANTINEOPLASTIC AGENT; CALCITRIOL; CALCIUM; FLUORINE; FLUORINE DERIVATIVE; SULFONE DERIVATIVE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CALCIUM URINE LEVEL; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; FLUORINATION; IN VIVO STUDY; MOUSE; NONHUMAN; STATISTICAL SIGNIFICANCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; CALCITRIOL; CALCIUM; CELL PROLIFERATION; FLUORINE; MOLECULAR STRUCTURE; RATS; SULFONES; VITAMIN D;

EID: 34250721753     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.05.051     Document Type: Article

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