Synthesis, radiolabeling and preliminary in vivo evaluation of [18F]FE-PE2I, a new probe for the dopamine transporter

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 16, 2009, Pages 4843-4845

  Schou, Magnus ^a   Steiger, Carsten ^a   Varrone, Andrea ^a,b   Guilloteau, Denis ^c   Halldin, Christer ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Stockholm Brain Institute   (Sweden)

^c UNIVERSITÉ DE TOURS   (France)

Author keywords

Dopamine transporter; PE2I; PET; Radioligand; Tropane

Indexed keywords

CARBON 11; COCAINE; DOPAMINE; DOPAMINE TRANSPORTER; FLUORINE 18; N (3 IODOPROP 2 ENYL) 2BETA CARBOFLUOROETHOXY 3BETA (4' METHYLPHENYL)NORTROPANE; NORTROPANE DERIVATIVE; RADIOLIGAND; UNCLASSIFIED DRUG; VANOXERINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DOPAMINE RELEASE; DOPAMINE UPTAKE; DRUG POTENCY; EVALUATION; IN VIVO STUDY; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITE; MOLECULAR PROBE; MONKEY; NONHUMAN; OXIDATION; POSITRON EMISSION TOMOGRAPHY; PRODUCT RECOVERY; RADIOACTIVITY; SYNTHESIS; TISSUE DISTRIBUTION;

ANIMALS; BRAIN; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FLUORINE RADIOISOTOPES; HAPLORHINI; HUMANS; ISOTOPE LABELING; KINETICS; NORTROPANES; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS;

RODENTIA;

EID: 67651097826     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.06.032     Document Type: Article

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