A novel functional haplotype in the human GNAS gene alters Gαs expression, responsiveness to β-adrenoceptor stimulation, and peri-operative cardiac performance

European Heart Journal

Volumn 30, Issue 11, 2009, Pages 1402-1410

  Frey, Ulrich H ^a   Adamzik, Michael ^a   Kottenberg Assenmacher, Eva ^a   Jakob, Heinz ^a   Manthey, Iris ^a   Broecker Preuss, Martina ^a   Bergmann, Lars ^a   Heusch, Gerd ^a   Siffert, Winfried ^a   Peters, Jürgen ^a   Leineweber, Kirsten ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Cardiac output; Genetics; Heart failure; Molecular biology

Indexed keywords

ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANOSINE TRIPHOSPHATE; ISOPRENALINE; METOPROLOL; GNAS PROTEIN, HUMAN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ADRENERGIC ACTIVITY; ADULT; AGED; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GENE SEQUENCE; GENETIC IDENTIFICATION; HAPLOTYPE; HEART FUNCTION; HEART HEMODYNAMICS; HEART PERFORMANCE; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRON; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; ADOLESCENT; GENETICS; HEART OUTPUT; METABOLISM; METHODOLOGY; MIDDLE AGED; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ADOLESCENT; ADULT; CARDIAC OUTPUT; CORONARY ARTERY BYPASS; FEMALE; GENE EXPRESSION; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; RECEPTORS, ADRENERGIC, BETA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; YOUNG ADULT;

EID: 67651094153     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehn572     Document Type: Article

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