Overexpression of myocardial Gsα prevents full expression of catecholamine desensitization despite increased β-adrenergic receptor kinase

Journal of Clinical Investigation

Volumn 101, Issue 9, 1998, Pages 1916-1922

  Vatner, Dorothy E ^a   Asai, Kuniya ^a   Iwase, Mitsunori ^a   Ishikawa, Yoshihiro ^a   Wagner, Thomas E ^a   Shannon, Richard P ^a   Homcy, Charles J ^b   Vatner, Stephen F ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

Adenylyl cyclase; Cardiomyopathy; Desensitization; G proteins; Transgenic mice

Indexed keywords

BETA ADRENERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; ADENYLATE CYCLASE; ADRBK2 PROTEIN, MOUSE; BETA ADRENERGIC RECEPTOR KINASE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP DEPENDENT PROTEIN KINASE; ISOPRENALINE; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CARDIOMYOPATHY; CHRONOTROPISM; DESENSITIZATION; INOTROPISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYMPATHETIC INNERVATION; TRANSGENIC MOUSE; AGE; ANIMAL; BINDING COMPETITION; BIOSYNTHESIS; DRUG EFFECT; DRUG POTENTIATION; FEMALE; GENETICS; HEART; HEART CONTRACTION; HEART LEFT VENTRICLE FUNCTION; HEART RATE; MALE; METABOLISM; NON-PROGRAMMATIC; PHYSIOLOGY; SIGNAL TRANSDUCTION;

NON-PROGRAMMATIC;

ADENYLATE CYCLASE; ADRENERGIC BETA-AGONISTS; AGE FACTORS; ANIMALS; BETA-ADRENERGIC RECEPTOR KINASE; BINDING, COMPETITIVE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FEMALE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HEART; HEART RATE; ISOPROTERENOL; MALE; MICE; MICE, TRANSGENIC; MYOCARDIAL CONTRACTION; RECEPTORS, ADRENERGIC, BETA; SIGNAL TRANSDUCTION; VENTRICULAR FUNCTION, LEFT;

EID: 0032056404     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1530     Document Type: Article

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