Parasympathetic regulation of heart rate in rats after 56 nephrectomy is impaired despite functionally intact cardiac vagal innervation

Nephrology Dialysis Transplantation

Volumn 24, Issue 8, 2009, Pages 2362-2370

  Kuncová, Jitka ^a   Svíglerová, Jitka ^a   Kummer, Wolfgang ^b   Rajdl, Daniel ^a   Chottová Dvořáková, Magdalena ^a   Tonar, Zbynk ^a   Nalos, Lukáš ^a   Štengl, Milan ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Asymmetric dimethylarginine; Chronic renal failure; Parasympathetic innervation; Rat heart; Subtotal nephrectomy

Indexed keywords

ATROPINE; CARRIER PROTEIN; CHOLINE ACETYLTRANSFERASE; CREATININE; METIPRANOLOL; MUSCARINIC M2 RECEPTOR; N(G),N(G) DIMETHYLARGININE; PROTEIN CHOLINE TRANSPORTER 1; UNCLASSIFIED DRUG; UREA; VESICULAR ACETYLCHOLINE TRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CHRONIC KIDNEY FAILURE; DYSAUTONOMIA; HEART INNERVATION; HEART RATE; MALE; NEPHRECTOMY; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASYMPATHETIC TONE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; UREA BLOOD LEVEL; UREMIA; VAGUS NERVE;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ATROPINE; BLOTTING, WESTERN; CARBACHOL; CARDIOTONIC AGENTS; CHOLINE O-ACETYLTRANSFERASE; HEART; HEART RATE; KIDNEY; MALE; METIPRANOLOL; NEPHRECTOMY; NERVE TISSUE PROTEINS; NOREPINEPHRINE; PARASYMPATHETIC NERVOUS SYSTEM; PARASYMPATHOLYTICS; PLASMA MEMBRANE NEUROTRANSMITTER TRANSPORT PROTEINS; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; VAGUS NERVE; VESICULAR ACETYLCHOLINE TRANSPORT PROTEINS;

EID: 67651093989     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfp123     Document Type: Article

References (50)

1. Robinson TG, Carr SJ. Cardiovascular autonomic dysfunction in uremia. Kidney Int 2002; 62: 1921-1932
2. Rostand SG, Brunzell JD, Cannon RO et al. Cardiovascular complications in renal failure. J Am Soc Nephrol 1991; 2: 1053-1062
3. Zoccali C, Ciccarelli M, Maggiore Q. Defective reflex control of heart rate in dialysis patients: evidence for an afferent autonomic lesion. Clin Sci (Lond) 1982; 63: 285-292
4. Bondia A, Tabernero JM, Macias JF et al. Autonomic nervous system in haemodialysis. Nephrol Dial Transplant 1988; 3: 174-180
5. Takahashi H, Matsuo S, Toriyama T et al. Autonomic dysfunction in hemodialysis patients with persistent hypotension. Nephron 1996; 72:418-423
6. Giordano M, Manzella D, Paolisso G et al. Differences in heart rate variability parameters during the post-dialytic period in type II diabetic and non-diabetic ESRD patients. Nephrol Dial Transplant 2001; 16: 566-573
7. Thomson BJ, McAreavey D, Neilson JM et al. Heart rate variability and cardiac arrhythmias in patients with chronic renal failure. Clin Auton Res 1991; 1: 131-133
8. Hathaway DK, Cashion AK, Milstead EJ et al. Autonomic dysregulation in patients awaiting kidney transplantation. Am J Kidney Dis 1998; 32: 221-229
9. Dhein S, Röhnert P, Markau S et al. Cardiac beta-adrenoceptors in chronic uremia: studies in humans and rats. J Am Coll Cardiol 2000; 36: 608-617
10. Yates MS, Askey EA, Bowmer CJ. Cardiovascular responses in rats with chronic renal failure. J Pharm Pharmacol 1987; 39: 711-716
11. Mallamaci F, Tripepi G, Maas R et al. Analysis of the relationship between norepinephrine and asymmetric dimethyl arginine levels among patients with end-stage renal disease. J Am Soc Nephrol 2004; 15: 435-441
12. Široká R, Trefil L, Rajdl D et al. Asymmetric dimethylarginine - comparison of HPLC and ELISA methods. J Chromatogr B Anal Technol Biomed Life Sci 2007; 850: 586-587
13. Batulevicius D, Neringa Pauziene N, Pauza DH. Topographic morphology and age-related analysis of the neuronal number of the rat intracardiac nerve plexus. Ann Anat 2003; 185: 449-459
14. Kurata C, Uehara A, Sugi T et al. Cardiac autonomic neuropathy in patients with chronic renal failure on hemodialysis. Nephron 2000; 84: 312-319
15. Augustyniak RA, Tuncel M, Zhang W et al. Sympathetic overactivity as a cause of hypertension in chronic renal failure. J Hypertens 2002; 20: 3-9
16. Koomans HA, Blankestijn PJ, Joles JA. Sympathetic hyperactivity in chronic renal failure: a wake-up call. J Am Soc Nephrol 2004; 15: 524-537
17. Ye S, Zhong H, Yanamadala V et al. Renal injury caused by intrarenal injection of phenol increases afferent and efferent renal sympathetic nerve activity. Am J Hypertens 2002; 15: 717-724
18. Leineweber K, Heinroth-Hoffmann I, Pönicke K et al. Cardiac betaadrenoceptor desensitization due to increased beta-adrenoceptor kinase activity in chronic uremia. J Am Soc Nephrol 2002; 13: 117-124
19. Grassi G, Esler M. How to assess sympathetic activity in humans. J Hypertens 1999; 17: 719-734
20. Kennedy D, Omran E, Periyasamy SM et al. Effect of chronic renal failure on cardiac contractile function, calcium cycling, and gene expression of proteins important for calcium homeostasis in the rat. J Am Soc Nephrol 2003; 14: 90-97
21. Donohoe P, McMahon AC, Walgama OV et al. L-type calcium current of isolated rat cardiacmyocytes in experimental uraemia. Nephrol Dial Transplant 2000; 15: 791-798
22. Zhang YB, Smogorzewski M, Ni Z et al. Altered cytosolic calcium homeostasis in rat cardiac myocytes in CRF. Kidney Int 1994; 45: 1113-1119
23. Satoh H. Sino-atrial nodal cells of mammalian hearts: ionic currents and gene expression of pacemaker ionic channels. J Smooth Muscle Res 2003; 39: 175-193
24. Sedmera D, Kucera P, Raddatz E. Developmental changes in cardiac recovery from anoxia-reoxygenation. Am J Physiol Regul Integr Comp Physiol 2002; 283: R379-R388
25. Stafford-Smith M. Heart and kidneys: sharing more than just blood. Curr Opin Anaesthesiol 2007; 20: 65-69
26. Zoccali C, Bode-Boger S, Mallamaci F et al. Plasma concentration of asymmetrical dimethylarginine and mortality in patients with endstage renal disease: a prospective study. Lancet 2001, 358: 2113-2117
27. Zoccali C, Mallamaci F, Maas R et al. Left ventricular hypertrophy, cardiac remodeling and asymmetric dimethylarginine (ADMA) in hemodialysis patients. Kidney Int 2002; 62: 339-345
28. Jacobi J, Tsao PS. Asymmetrical dimethylarginine in renal disease: limits of variation or variation limits? a systematic review. Am J Nephrol 2008; 28: 224-237
29. Vallance P, Leone A, Calver A et al. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 1992; 339: 572-575
30. Matsuguma K, Ueda S, Yamagishi S et al. Molecular mechanism for elevation of asymmetric dimethylarginine and its role for hypertension in chronic kidney disease. J Am Soc Nephrol 2006; 17: 2176-2183
31. Achan V, Broadhead M, Malaki M et al. Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase. Arterioscler Thromb Vasc Biol 2003; 23: 1455-1459
32. Abu-Alfa A, Mujais SK. Uremic pancreopathy: impaired secretory function in vitro. Am J Kidney Dis 1992; 20: 585-588
33. Yildiz F, Tugay M, Utkan T et al. Effect of chronic renal failure on foregut smooth muscle reactivity: an experimental study. J Pediatr Surg 2007; 42: 647-652.
34. Hasdan G, Benchetrit S, Rashid G et al. Endothelial dysfunction and hypertension in 5/6 nephrectomized rats are mediated by vascular superoxide. Kidney Int 2002; 61: 586-590
35. Morris ST, McMurray JJ, Spiers A et al. Impaired endothelial function in isolated human uremic resistance arteries. Kidney Int 2001; 60: 1077-1082
36. Yates MS, Critchley MA, Askey EA et al. Cardiac reactivity in rats with acute renal failure. J Pharm Pharmacol 1985; 37: 175-179
37. Arvidsson U, Riedl M, Elde R et al. Vesicular acetylcholine transporter (VAChT) protein: a novel and unique marker for cholinergic neurons in the central and peripheral nervous systems. J Comp Neurol 1997; 378: 454-467
38. Castell X, Diebler MF, Tomasi M et al. More than one way to toy with ChAT and VAChT. J Physiol Paris 2002; 96: 61-72
39. Dolezal V, Castell X, Tomasi M et al. Stimuli that induce a cholinergic neuronal phenotype of NG108 - 15 cells up regulate ChAT and VAChT mRNAs but fail to increase VAChT protein. Brain Res Bull 2001; 54: 363-373
40. Brock M, Nickel AC, Madziar B et al. Differential regulation of the high affinity choline transporter and the cholinergic locus by cAMP signaling pathways. Brain Res 2007; 1145: 1-10
41. Riley SP, Talbot NJ, Ahmed MJ et al. Characterization of human erythrocyte choline transport in chronic renal failure. Nephrol Dial Transplant 1997; 12: 1921-1927
42. Ni Z, Smogorzewski M, Massry SG. Derangements in acetylcholine metabolism in brain synaptosomes in chronic renal failure. Kidney Int 1993; 44: 630-637
43. Korner PI, Langsford G, Starr D et al. The effects of chloraloseurethane and sodium pentobarbitone anaesthesia on the local and autonomic components of the circulatory response to arterial hypoxia. J Physiol 1968; 199: 283-302
44. Shimokawa A, Kunitake T, Takasaki M et al. Differential effects of anesthetics on sympathetic nerve activity and arterial baroreceptor reflex in chronically instrumented rats. J Auton Nerv Syst 1998; 72: 46-54
45. Smogorzewski MJ. Central nervous dysfunction in uremia. Am J Kidney Dis 2001; 38(Suppl 1): S122-S128
46. Agildere AM, Kurt A, Yildirim T et al. MRI of neurologic complications in end-stage renal failure patients on hemodialysis: pictorial review. Eur Radiol 2001; 11: 1063-1069
47. Kotani K, Shu-Ichi U, Sano A et al. Isolation and identification of methylation ofmethylarginines from bovine brain. J Neurochem 1992; 58: 1127-1129
48. Abe T, Tohgi H, Murata T et al. Reduction in asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in the cerebrospinal fluid during aging and in patients with Alzheimer's disease. Neurosci Lett 2001; 312: 177-179
49. De Deyn PP, Marescau B, D'Hooge R et al. Guanidino compound levels in brain regions of non-dialyzed uremic patients. Neurochem Int 1995; 27: 227-237
50. Kamendi H, Dergacheva O, Wang X et al. NO differentially regulates neurotransmission to premotor cardiac vagal neurons in the nucleus ambiguus. Hypertension 2006; 48: 1137-1142