Model-based evaluation of plasmid segregational instability in repeated batch culture with recombinant Escherichia coli

Chemical Engineering Journal

Volumn 153, Issue 1-3, 2009, Pages 227-230

  Mathur, Ashwani ^a   Chand, Subhash ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY DELHI   (India)

Author keywords

Plasmid instability; Random segregation; Repeated batch; Replica plating

Indexed keywords

AMYLASE GENES; BACILLUS AMYLOLIQUEFACIENS; FREE CELLS; MATHEMATICAL CORRELATION; MODEL-BASED EVALUATION; OVER-EXPRESSION; PLASMID INSTABILITY; PLASMID SIZE; PLASMID-BEARING CELLS; RANDOM SEGREGATION; RECOMBINANT ESCHERICHIA COLI; RECOMBINANT HOSTS; RECOMBINANT PLASMID; RECOMBINANT PROTEIN; REPEATED BATCH; REPEATED-BATCH CULTURE; REPLICA PLATING; SELECTION PRESSURES; TECHNOLOGICAL ADVANCEMENT;

BACTERIOLOGY; BATCH CELL CULTURE; BIOCHEMISTRY; CELL CULTURE; ESCHERICHIA COLI; MATHEMATICAL MODELS; MOLECULAR BIOLOGY; PROTEINS; SEGREGATION (METALLOGRAPHY);

STABILITY;

BACILLUS AMYLOLIQUEFACIENS; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 67651087471     PISSN: 13858947     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cej.2009.06.015     Document Type: Article

References (17)

1. McLoughlin A.J. Plasmid stability and ecological competence in recombinant cultures. Biotechol. Adv. 12 (1994) 279-324
2. Kumar P.K.R., Maschke H.E., Friehs K., and Schuegerl K. Strategies for improving plasmid stability in genetically modified bacteria in bioreactors. Trends Biotechnol. 9 (1991) 279-284
3. Maschke H.E., Kumar P.K.R., Geiger R., and Schuegerl K. Plasmid instabilities of single and three-plasmid systems in Escherichia coli during continuous cultivation. J. Biotechnol. 24 (1992) 235-251
4. Austin S.J. Plasmid partition. Plasmid 20 (1988) 1-9
5. Pogliano J. Dynamic cellular location of bacterial plasmids. Curr. Opin. Microbiol. 5 (2002) 586-590
6. De Taxis Du Poet P., Dhulster P., Barbotin J.N., and Thomas D. Plasmid inheritibility and biomass production: comparison between free and immobilized cell cultures of Escerichia coli BZ 18 (pTG 201) without selection pressure. J. Bacteriol. 165 (1986) 871-877
7. Cooper N.S., Brown M.E., and Caulcott C.A. A mathematical method for analyzing plasmid stability in microorganisms. J. Gen. Microbiol. 133 (1987) 1871-1880
8. Imanaka T., and Aiba S. A perspective on the application of genetic engineering: stability of recombinant plasmids. Ann. N.Y. Acad. Sci. 369 (1981) 1-14
9. Lee S.B., Seressiotis A., and Bailey J.E. A kinetic model for product formation in unstable recombinant populations. Biotech. Bioeng. 27 (1985) 1699-1709
10. Baheri H.R., Hill G.A., and Roesler W.J. Modelling plasmid instability in batch and continuous fermentors. Biochem. Eng. J. 8 (2001) 45-50
11. Huang C.T., Peretti S.W., and Bryers J.D. Plasmid retention and gene expression in suspended and biofilm culture of recombinant Escherichia coli DH5α(pMJR1750). Biotechnol. Bioeng. 41 (1993) 211-220
12. Mujacic M., Cooper K.W., and Baneyx F. Cold inducible cloning vectors for low temperature protein expression in Escherichia coli: application to the production of a toxic and proteolytically sensitive fusion protein. Gene 238 (1999) 325-332
13. Lechevalier H.A., and Corke C.T. The replica plate method for screening antibiotic-producing organisms. Appl. Microbiol. 1 (1953) 110-112
14. Cheah U.E., Weigand W.A., and Stark B.C. Effects of recombinant plasmid size on cellular processes in Escherichia coli. Plasmid 18 (1987) 127-134
15. Castan A., Näsman A., and Enfors S. Oxygen enriched air supply in Escherichia coli processes: production of biomass and recombinant human growth hormone. Enzyme Microb. Technol. 30 (2002) 847-854
16. Khosravi M., Ryan W., Webster D.A., and Stark B.C. Variation of oxygen requirement with plasmid size in recombinant Escherichia coli. Plasmid 23 (1990) 138-143
17. Bhattacharya S.K., and Dubey A.K. Metabolic burden as reflected by maintenance coefficient of recombinant Escherichia coli overexpressing target gene. Biotechnol. Lett. 17 (1995) 1155-1160