Antimicrobial agents for complicated skin and skin-structure infections: Noninferiority margins, placebo-controlled trials, and the complexity of clinical trials

Clinical Infectious Diseases

Volumn 49, Issue 3, 2009, Pages 392-394

  Stevens, Dennis L ^a,b  

^a Boise VA Medical Center   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; PENICILLIN G; PLACEBO; SULFONAMIDE;

FOOD AND DRUG ADMINISTRATION; HUMAN; NOTE; PHYSICIAN; PRIORITY JOURNAL; SKIN INFECTION; SKIN STRUCTURE; SOFT TISSUE INFECTION; TREATMENT RESPONSE;

ANTI-INFECTIVE AGENTS; BACTERIA; DRUG APPROVAL; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SKIN DISEASES, BACTERIAL; TREATMENT OUTCOME; UNITED STATES;

EID: 67651085131     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/600297     Document Type: Note

References (3)

1. Hippocrates with an English translation by Francis Adams. Volume 1. London: Sydenham Society, 1849:377.
2. Stevens DL, Bisno AL, Chambers HF, et al. Practice guidelines for the diagnosis and management of skin and soft-tissue infections. Clin Infect Dis 2005; 41:1373-406.
3. Spellberg B, Talbot GH, Boucher HW, et al. Antimicrobial agents for complicated skin and skin-structure infections: justification of noninferiority margins in the absence of placebo-controlled trials. Clin Infect Dis 2009; 49: 383-91 (in this issue).