An fMRI study on the interaction and dissociation between expectation of pain relief and acupuncture treatment

NeuroImage

Volumn 47, Issue 3, 2009, Pages 1066-1076

  Kong, Jian ^a,b   Kaptchuk, Ted J ^c   Polich, Ginger ^a   Kirsch, Irving ^d   Vangel, Mark ^a,b   Zyloney, Carolyn ^a   Rosen, Bruce ^b   Gollub, Randy L ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF HULL   (United Kingdom)

Author keywords

Acupuncture; Acupuncture analgesia; Conditioning; Expectancy; Expectancy manipulation; Pain; Placebo; Placebo analgesia; Sham acupuncture needle

Indexed keywords

PLACEBO;

ACUPUNCTURE ANALGESIA; ADULT; ARTICLE; CALIBRATION; CONDITIONING; EXPECTANCY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; HUMAN EXPERIMENT; IMAGE ANALYSIS; MALE; NEUROIMAGING; NEUROMODULATION; NOCICEPTION; NOCICEPTIVE STIMULATION; NORMAL HUMAN; PAIN; PAIN ASSESSMENT; PRIORITY JOURNAL; SIGNAL DETECTION; THERMAL STIMULATION; TREATMENT RESPONSE;

ACUPUNCTURE ANALGESIA; BRAIN; BRAIN MAPPING; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; PAIN; PLACEBO EFFECT; PLACEBOS;

EID: 67651062825     PISSN: 10538119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2009.05.087     Document Type: Article

References (69)

1. Benedetti F. Mechanisms of placebo and placebo-related effects across diseases and treatments. Annu. Rev. Pharmacol. Toxicol. 48 (2008) 33-60
2. Benedetti F., Arduino C., and Amanzio M. Somatotopic activation of opioid systems by target-directed expectations of analgesia. J. Neurosci. 19 (1999) 3639-3648
3. Benedetti F., Mayberg H.S., Wager T.D., Stohler C.S., and Zubieta J.K. Neurobiological mechanisms of the placebo effect. J. Neurosci. 25 (2005) 10390-10402
4. Benedetti F., Amanzio M., Vighetti S., and Asteggiano G. The biochemical and neuroendocrine bases of the hyperalgesic nocebo effect. J. Neurosci. 26 (2006) 12014-12022
5. Bingel U., Lorenz J., Schoell E., Weiller C., and Buchel C. Mechanisms of placebo analgesia: rACC recruitment of a subcortical antinociceptive network. Pain 120 (2006) 8-15
6. Brinkhaus B., Witt C.M., Jena S., Linde K., Streng A., Wagenpfeil S., Irnich D., Walther H.U., Melchart D., and Willich S.N. Acupuncture in patients with chronic low back pain: a randomized controlled trial. Arch. Intern. Med. 166 (2006) 450-457
7. Chizh B.A., Greenspan J.D., Casey K.L., Nemenov M.I., and Treede R.D. Identifying biological markers of activity in human nociceptive pathways to facilitate analgesic drug development. Pain 140 (2008) 249-253
8. Colloca L., Tinazzi M., Recchia S., Le Pera D., Fiaschi A., Benedetti F., and Valeriani M. Learning potentiates neurophysiological and behavioral placebo analgesic responses. Pain 139 (2008) 306-314
9. Craggs J.G., Price D.D., Verne G.N., Perlstein W.M., and Robinson M.M. Functional brain interactions that serve cognitive-affective processing during pain and placebo analgesia. Neuroimage 38 (2007) 720-729
10. Critchley H.D. The human cortex responds to an interoceptive challenge. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 6333-6334
11. de Jong P.J., van Baast R., Arntz A., and Merckelbach H. The placebo effect in pain reduction: the influence of conditioning experiences and response expectancies. Int. J. Behav. Med. 3 (1996) 14-29
12. De Pascalis V., Chiaradia C., and Carotenuto E. The contribution of suggestibility and expectation to placebo analgesia phenomenon in an experimental setting. Pain 96 (2002) 393-402
13. Dougherty D.D., Kong J., Webb M., Bonab A.A., Fischman A.J., and Gollub R.L. A combined [11C]diprenorphine PET study and fMRI study of acupuncture analgesia. Behav. Brain Res. 193 (2008) 63-68
14. Ernst E. Acupuncture-a critical analysis. J. Intern. Med. 259 (2006) 125-137
15. Feather B.W., Chapman C.R., and Fisher S.B. The effect of a placebo on the perception of painful radiant heat stimuli. Psychosom. Med. 34 (1972) 290-294
16. Fregni F., Boggio P.S., Bermpohl F., Maia F., Rigonatti S.P., Barbosa E.R., and Pascual-Leone A. Immediate placebo effect in Parkinson's disease-is the subjective relief accompanied by objective improvement?. Eur. Neurol. 56 (2006) 222-229
17. Gracely R.H., McGrath P.A., and Dubner R. Ratio scales of sensory and affective verbal pain descriptors. Pain 5 (1978) 5-18
18. Gracely R.H., McGrath P.A., and Dubner R. Validity and sensitivity of ratio scales of sensory and affective verbal pain descriptors: manipulation of affect by diazepam. Pain 5 (1978) 19-29
19. Haake M., Muller H.H., Schade-Brittinger C., Basler H.D., Schafer H., Maier C., Endres H.G., Trampisch H.J., and Molsberger A. German Acupuncture Trials (GERAC) for chronic low back pain: randomized, multicenter, blinded, parallel-group trial with 3 groups. Arch. Intern. Med. 167 (2007) 1892-1898
20. Han J.S. Acupuncture: neuropeptide release produced by electrical stimulation of different frequencies. Trends Neurosci. 26 (2003) 17-22
21. Kalisch R., Wiech K., Critchley H.D., Seymour B., O'Doherty J.P., Oakley D.A., Allen P., and Dolan R.J. Anxiety reduction through detachment: subjective, physiological, and neural effects. J. Cogn. Neurosci. 17 (2005) 874-883
22. Kaptchuk T.J. The Web That Has No Weaver: Understanding Chinese Medicine (2000), Contemporary Books (McGraw-Hill), Chicago
23. Kaptchuk T.J. Acupuncture: theory, efficacy, and practice. Ann. Intern. Med. 136 (2002) 374-383
24. Kelley J.M., Boulos P.R., Rubin P.A.D., and Kaptchuk T.J. Mirror, mirror on the wall: placebo effects that exist only in the eye of the beholder. J. Eval. Clin. Pract. 15 (2009) 292-298
25. Kleinhenz J., Streitberger K., Windeler J., Gussbacher A., Mavridis G., and Martin E. Randomised clinical trial comparing the effects of acupuncture and a newly designed placebo needle in rotator cuff tendinitis. Pain 83 (1999) 235-241
26. Kong J., Fufa D.T., Gerber A.J., Rosman I.S., Vangel M.G., Gracely R.H., and Gollub R.L. Psychophysical outcomes from a randomized pilot study of manual, electro, and sham acupuncture treatment on experimentally induced thermal pain. J. Pain. 6 (2005) 55-64
27. Kong J., Gollub R.L., Rosman I.S., Webb J.M., Vangel M.G., Kirsch I., and Kaptchuk T.J. Brain activity associated with expectancy-enhanced placebo analgesia as measured by functional magnetic resonance imaging. J. Neurosci. 26 (2006) 381-388
28. Kong J., White N.S., Kwong K.K., Vangel M.G., Rosman I.S., Gracely R.H., and Gollub R.L. Using fMRI to dissociate sensory encoding from cognitive evaluation of heat pain intensity. Hum. Brain Mapp. 27 (2006) 715-721
29. Kong J., Gollub R., Huang T., Polich G., Napadow V., Hui K., Vangel M., Rosen B., and Kaptchuk T.J. Acupuncture de qi, from qualitative history to quantitative measurement. J. Altern. Complement. Med. 13 (2007) 1059-1070
30. Kong J., Gollub R.L., Webb J.M., Kong J.T., Vangel M.G., and Kwong K. Test-retest study of fMRI signal change evoked by electro-acupuncture stimulation. Neuroimage 1171-1181 (2007)
31. Kong J., Kaptchuk T.J., Polich G., Kirsch I., and Gollub R.L. Placebo analgesia: findings from brain imaging studies and emerging hypotheses. Rev. Neurosci. 18 (2007) 173-190
32. Kong J., Gollub R.L., Polich G., Kirsch I., Laviolette P., Vangel M., Rosen B., and Kaptchuk T.J. A functional magnetic resonance imaging study on the neural mechanisms of hyperalgesic nocebo effect. J. Neurosci. 28 (2008) 13354-13362
33. Kong J., Kaptachuk T.J., Polich G., Kirsch I.V., Angel M., Zyloney C., Rosen B., and Gollub R. Expectancy and treatment interactions: a dissociation between acupuncture analgesia and expectancy evoked placebo analgesia. Neuroimage 45 (2009) 940-949
34. Leibing E., Leonhardt U., Koster G., Goerlitz A., Rosenfeldt J.A., Hilgers R., and Ramadori G. Acupuncture treatment of chronic low-back pain - a randomized, blinded, placebo-controlled trial with 9-month follow-up. Pain 96 (2002) 189-196
35. Lieberman M.D., Jarcho J.M., Berman S., Naliboff B.D., Suyenobu B.Y., Mandelkern M., and Mayer E.A. The neural correlates of placebo effects: a disruption account. Neuroimage 22 (2004) 447-455
36. Linde K., Vickers A., Hondras M., ter Riet G., Thormahlen J., Berman B., and Melchart D. Systematic reviews of complementary therapies - an annotated bibliography. Part 1: acupuncture. BMC Complement. Altern. Med. 1 (2001) 3
37. Linde K., Streng A., Jurgens S., Hoppe A., Brinkhaus B., Witt C., Wagenpfeil S., Pfaffenrath V., Hammes M.G., Weidenhammer W., Willich S.N., and Melchart D. Acupuncture for patients with migraine: a randomized controlled trial. JAMA 293 (2005) 2118-2125
38. Linde K., Witt C.M., Streng A., Weidenhammer W., Wagenpfeil S., Brinkhaus B., Willich S.N., and Melchart D. The impact of patient expectations on outcomes in four randomized controlled trials of acupuncture in patients with chronic pain. Pain 128 (2007) 264-271
39. Liu T. Acupuncture: what underlies needle administration?. Evid. Based Complement. Alternat. Med. (2008) doi:10.1093/ecam/nen1002
40. McManus C.A., Schnyer R.N., Kong J., Nguyen L.T., Hyun Nam B., Goldman R., Stason W.B., and Kaptchuk T.J. Sham acupuncture devices - practical advice for researchers. Acupunct. Med. 25 (2007) 36-40
41. Melchart D., Streng A., Hoppe A., Brinkhaus B., Witt C., Wagenpfeil S., Pfaffenrath V., Hammes M., Hummelsberger J., Irnich D., Weidenhammer W., Willich S.N., and Linde K. Acupuncture in patients with tension-type headache: randomised controlled trial. Bmj 331 (2005) 376-382
42. Melzack R. Folk medicine and the sensory modulation of pain. In: Wall P.D., and Melzack R. (Eds). Textbook of Pain (1989), Churchill Livingstone, Edinburgh 1209-1223
43. Mesulam M.M. From sensation to cognition. Brain 121 (1998) 1013-1052
44. Miller E.K., and Cohen J.D. An integrative theory of prefrontal cortex function. Annu. Rev. Neurosci. 24 (2001) 167-202
45. Montgomery G.H., and Kirsch I. Classical conditioning and the placebo effect. Pain 72 (1997) 107-113
46. Nickel J.C. Placebo therapy of benign prostatic hyperplasia: a 25-month study. Canadian PROSPECT Study Group. Br. J. Urol. 81 (1998) 383-387
47. Petrovic P., and Ingvar M. Imaging cognitive modulation of pain processing. Pain 95 (2002) 1-5
48. Petrovic P., Kalso E., Petersson K.M., and Ingvar M. Placebo and opioid analgesia - imaging a shared neuronal network. Science 295 (2002) 1737-1740
49. Pomeranz B. Scientific basis of acupuncture. In: Stux G., and Pomeranz B. (Eds). Basics of Acupuncture (1997), Springer, Berlin 6-72
50. Price D.D., Milling L.S., Kirsch I., Duff A., Montgomery G.H., and Nicholls S.S. An analysis of factors that contribute to the magnitude of placebo analgesia in an experimental paradigm. Pain 83 (1999) 147-156
51. Price D.D., Craggs J., Verne G.N., Perlstein W.M., and Robinson M.E. Placebo analgesia is accompanied by large reductions in pain-related brain activity in irritable bowel syndrome patients. Pain 127 (2007) 63-72
52. Schweinhardt P., Bountra C., and Tracey I. Pharmacological FMRI in the development of new analgesic compounds. NMR Biomed. 19 (2006) 702-711
53. Scott D.J., Stohler C.S., Egnatuk C.M., Wang H., Koeppe R.A., and Zubieta J.K. Individual differences in reward responding explain placebo-induced expectations and effects. Neuron 55 (2007) 325-336
54. Scott D.J., Stohler C.S., Egnatuk C.M., Wang H., Koeppe R.A., and Zubieta J.K. Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses. Arch. Gen. Psychiatry 65 (2008) 220-231
55. Sharot T., Riccardi A.M., Raio C.M., and Phelps E.A. Neural mechanisms mediating optimism bias. Nature 450 (2007) 102-105
56. Shin L.M., Orr S.P., Carson M.A., Rauch S.L., Macklin M.L., Lasko N.B., Peters P.M., Metzger L.J., Dougherty D.D., Cannistraro P.A., Alpert N.M., Fischman A.J., and Pitman R.K. Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD. Arch. Gen. Psychiatry 61 (2004) 168-176
57. Shin L.M., Wright C.I., Cannistraro P.A., Wedig M.M., McMullin K., Martis B., Macklin M.L., Lasko N.B., Cavanagh S.R., Krangel T.S., Orr S.P., Pitman R.K., Whalen P.J., and Rauch S.L. A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder. Arch. Gen. Psychiatry 62 (2005) 273-281
58. Streitberger K., and Kleinhenz J. Introducing a placebo needle into acupuncture research. Lancet 352 (1998) 364-365
59. van Leeuwen J.H., Castro R., Busse M., and Bemelmans B.L. The placebo effect in the pharmacologic treatment of patients with lower urinary tract symptoms. Eur. Urol. 50 (2006) 440-452 discussion 453
60. Vogt B.A. Pain and emotion interactions in subregions of the cingulate gyrus. Nat. Rev. Neurosci. 6 (2005) 533-544
61. Volkow N.D., Wang G.J., Ma Y., Fowler J.S., Zhu W., Maynard L., Telang F., Vaska P., Ding Y.S., Wong C., and Swanson J.M. Expectation enhances the regional brain metabolic and the reinforcing effects of stimulants in cocaine abusers. J. Neurosci. 23 (2003) 11461-11468
62. Volkow N.D., Wang G.J., Ma Y., Fowler J.S., Wong C., Jayne M., Telang F., and Swanson J.M. Effects of expectation on the brain metabolic responses to methylphenidate and to its placebo in non-drug abusing subjects. Neuroimage 32 (2006) 1782-1792
63. Voudouris N.J., Peck C.L., and Coleman G. The role of conditioning and verbal expectancy in the placebo response. Pain 43 (1990) 121-128
64. Wager T.D., Rilling J.K., Smith E.E., Sokolik A., Casey K.L., Davidson R.J., Kosslyn S.M., Rose R.M., and Cohen J.D. Placebo-induced changes in FMRI in the anticipation and experience of pain. Science 303 (2004) 1162-1167
65. Wager T.D., Scott D.J., and Zubieta J.K. Placebo effects on human mu-opioid activity during pain. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 11056-11061
66. White P., Lewith G., Hopwood V., and Prescott P. The placebo needle, is it a valid and convincing placebo for use in acupuncture trials? A randomised, single-blind, cross-over pilot trial. Pain 106 (2003) 401-409
67. Zhang W.T., Jin Z., Cui G.H., Zhang K.L., Zhang L., Zeng Y.W., Luo F., Chen A.C., and Han J.S. Relations between brain network activation and analgesic effect induced by low vs. high frequency electrical acupoint stimulation in different subjects: a functional magnetic resonance imaging study. Brain Res. 982 (2003) 168-178
68. Zhang W.T., Jin Z., Huang J., Zhang L., Zeng Y.W., Luo F., Chen A.C., and Han J.S. Modulation of cold pain in human brain by electric acupoint stimulation: evidence from fMRI. Neuroreport 14 (2003) 1591-1596
69. Zubieta J.K., Bueller J.A., Jackson L.R., Scott D.J., Xu Y., Koeppe R.A., Nichols T.E., and Stohler C.S. Placebo effects mediated by endogenous opioid activity on mu-opioid receptors. J. Neurosci. 25 (2005) 7754-7762