Diagnostic performance of quantitative κ and λ free light chain assays in clinical practice

Clinical Chemistry

Volumn 51, Issue 5, 2005, Pages 878-881

  Katzmann, Jerry A ^a   Abraham, Roshini S ^b   Dispenzieri, Angela ^b   Lust, John A ^b   Kyle, Robert A ^b  

^a MAYO CLINIC   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN;

AMYLOIDOSIS; ARTICLE; BONE MARROW; CLINICAL LABORATORY; CLINICAL PRACTICE; CONTROLLED STUDY; ELECTROPHORESIS; FREE LIGHT CHAIN ASSAY; HUMAN; IMMUNOFIXATION ELECTROPHORESIS; IMMUNOGLOBULIN DEPOSITION; MACROGLOBULINEMIA; MAJOR CLINICAL STUDY; MONOCLONAL IMMUNOGLOBULINEMIA; MULTIPLE MYELOMA; PERFORMANCE; PLASMA CELL; PLASMACYTOMA; QUANTITATIVE ASSAY; SENSITIVITY AND SPECIFICITY;

AMYLOIDOSIS; CLINICAL LABORATORY INFORMATION SYSTEMS; HUMANS; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN LAMBDA-CHAINS; LABORATORIES, HOSPITAL; MEDICAL RECORDS SYSTEMS, COMPUTERIZED; MULTIPLE MYELOMA; PARAPROTEINEMIAS; PLASMACYTOMA; WALDENSTROM MACROGLOBULINEMIA;

BIKINIA LE-TESTUI;

EID: 17744370515     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1373/clinchem.2004.046870     Document Type: Article

References (7)

1. Katzmann JA, Clark RJ, Abraham RS, Bryant S, Lymp JF, Bradwell AR, et al. Serum reference intervals and diagnostic ranges for free κ and free λ immunoglobulin light chains: relative sensitivity for detection of monoclonal light chains. Clin Chem 2002;48:1437-44.
2. Drayson MT, Tang LX, Drew R, Mead GP, Carr-Smith HD, Bradwell AR. Serum free light-chain measurements for identifying and monitoring patients with nonsecretory multiple myeloma. Blood 2001;97:2900-2.
3. Lachmann HJ, Gallimore R, Gillmore JD, Carr-Smith HD, Bradwell AR, Pepys MB, et al. Outcome in systemic AL amyloidosis in relation to changes in concentration of circulating free immunoglobulin light chains following chemotherapy. Br J Haematol 2003; 122:78-84.
4. Abraham RS, Katzmann JA, Clark RJ, Bradwell AR, Kyle RA, Gertz MA. Quantitative analysis of serum free light chains. A new marker for the diagnostic evaluation of primary systemic amyloidosis. Am J Clin Pathol 2003;119:274-8.
5. Bradwell AR, Mead GP, Carr-Smith HD, Drayson MT. Serum test for assessment of patients with Bence Jones myeloma. Lancet 2003;361:489-91.
6. Bradwell AR, Carr-Smith HD, Mead GP, Tang LX, Showell PJ, Drayson MT, et al. Highly sensitive automated immunoassay for immunoglobulin free light chains in serum and urine. Clin Chem 2001;47:673-80.
7. Rajkumar SV, Kyle RA, Therneau TM, Clark RJ, Bradwell AR, Melton LJ III, et al. Presence of monoclonal free light chains in the serum predicts risk of progression in monoclonal gammopathy of undetermined significance. Br J Haematol 2004;127:308-10.