Phase I study of concurrent chemoradiotherapy with weekly cisplatin and paclitaxel chemotherapy for locally advanced cervical carcinoma in Japanese women

International Journal of Gynecological Cancer

Volumn 19, Issue 4, 2009, Pages 723-727

  Umayahara, Kenji ^a   Takeshima, Nobuhiro ^a   Nose, Takayuki ^a   Fujiwara, Kiyoshi ^a   Sugiyama, Yuko ^a   Utsugi, Kuniko ^a   Yamashita, Takashi ^a   Takizawa, Ken ^a  

^a CANCER INSTITUTE HOSPITAL   (Japan)

Author keywords

Cervical carcinoma; Cisplatin; Concurrent chemoradiotherapy; Paclitaxel

Indexed keywords

CISPLATIN; PACLITAXEL;

ADULT; ADVANCED CANCER; AGED; ANEMIA; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CHEMOTHERAPY INDUCED EMESIS; CLINICAL ARTICLE; CLINICAL TRIAL; DEHYDRATION; DIARRHEA; DRUG DOSE ESCALATION; DRUG DOSE INCREASE; DRUG HYPERSENSITIVITY; DRUG WITHDRAWAL; FEMALE; HEART ARRHYTHMIA; HUMAN; IRRADIATION; JAPANESE; LEUKOPENIA; MAXIMUM TOLERATED DOSE; NAUSEA; NEUTROPENIA; OUTCOME ASSESSMENT; PELVIS; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RADIATION DOSE; SQUAMOUS CELL CARCINOMA; THROMBOCYTOPENIA; TREATMENT RESPONSE; UTERINE CERVIX CANCER; UTERINE CERVIX CARCINOMA;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BRACHYTHERAPY; CISPLATIN; COMBINED MODALITY THERAPY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; MIDDLE AGED; PACLITAXEL; UTERINE CERVICAL NEOPLASMS; YOUNG ADULT;

EID: 67651039794     PISSN: 1048891X     EISSN: None     Source Type: Journal    
DOI: 10.1111/IGC.0b013e3181a47b53     Document Type: Article

References (24)

1. Rose PG, Ali S, Watkins E, et al. Gynecologic Oncology Group. Long-term follow-up of a randomized trial comparing concurrent single agent cisplatin, cisplatin-based combination chemotherapy, or hydroxyurea during pelvic irradiation for locally advanced cervical cancer: a Gynecologic Oncology Group Study. J Clin Oncol. 2007; 25:2804-2810.
2. Moore D, Blessing J, McQuellon R, et al. Phase III study of cisplatin with or without paclitaxel in stage IVb, recurrent, or persistent squamous cell carcinoma of the cervix: A gynecologic Oncology Group study. J Clin Oncol. 2004;22:3113-3119.
3. DiSilvestro P, Walker J, Morrison A, et al. Radiation therapy with concomitant paclitaxel and cisplatin chemotherapy in cervical carcinoma limited to the pelvis: A phase I/II study of the Gynecologic Oncology Group. Gynecol Oncol. 2006;103:1038-1042.
4. Whitney CW, Sause W, Bundy BN, et al. Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIb-IVa carcinoma of the uterine cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study. J Clin Oncol. 1999;17:1339-1348.
5. Keys HM, Bundy BN, Stehman FB, et al. Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage Ib cervical carcinoma. N Engl J Med. 1999;340:1154-1161.
6. Morris M, Eifel PJ, Lu J, et al. Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high risk cervical cancer. N Engl J Med. 1999;340:1137-1143.
7. Rose PG, Bundy BN, Watkins EB, et al. Concurrent cisplatin based radiotherapy and chemotherapy for locally advanced cervical cancer. N Engl J Med. 1999;340:1144-1153.
8. Arai T, Nakano T, Morita S, et al. High-dose-rate remote after loading intracavitary radiation therapy for cancer of the uterine cervix: a 20-year experience. Cancer. 1992;69:175-180.
9. Sakurai H, Mituhashi N, Takahashi M, et al. Analysis of recurrence of squamous cell carcinoma of the uterine cervix after definitive radiation therapy alone patterns of recurrence, latent periods and prognosis. Int J Radiat Oncl Biol Phys. 2001;50:1136-1144.
10. Teshima T, Inoue T, Ikeda H, et al. High-dose rate and low-dose rate intracavitary therapy for carcinoma of the uterine cervix. Final results of Osaka University Hospital. Cancer. 1993;72:2409-2414.
11. Ota T, Takeshima N, Tabata T, et al. Treatment of squamous cell carcinoma of the uterine cervix with radiation therapy alone: long-term survival, late complications, and incidence of second cancers. Br J Cancer. 2007;97:1058-1062.
12. Nakano T, Kato S, Ohno T, et al. Long-term results of high-dose rate intracavitary brachytherapy for squamous cell carcinoma of the uterine cervix. Cancer. 2005;103:92-101.
13. Wheeless CR Jr, Graham R, Graham JB. Prognosis and treatment of adenoepidermoid carcinoma of the cervix. Obstet Gynecol. 1970;35: 928-932.
14. Rombaut RP, Charles D, Murphy A. Adenocarcinoma of the cervix. A clinicopathologic study of 47 cases. Cancer. 1966;19:891-900.
15. Rutledge FN, Galakatos AE, Wharton JT, et al. Adenocarcinoma of the uterine cervix. Am J Obstet Gynecol. 1975;122:236-245.
16. Berek JS, Castaldo TW, Hacker NF, et al. Adenocarcinoma of the uterine cervix. Cancer. 1981;48:1734-2741.
17. Pearcey R, Brundage M, Drouin P, et al. Phase III trial comparing radical radiotherapy with and without cisplatin chemotherapy in patients with advanced squamous cell cancer of the cervix. J Clin Oncol. 2002;20: 966-972.
18. Ohno T, Kato S, Tsujii H. Phase I study of weekly cisplatin plus radiotherapy for locally advanced cervical cancer [In Japanese]. Jpn J Gynecol Oncol. 2004;22:298.
19. Jaakkola M, Rantanen V, Grenman S, et al. In vitro concurrent paclitaxel and radiation of four vulvar squamous cell carcinoma cell lines. Cancer. 1996;77:1940-1946.
20. Jekunen A, Christen R, Shalinsky D, et al. Synergistic interaction between cisplatin and taxol in human ovarian carcinoma cells in vitro. Br J Cancer. 1994;69:299-306.
21. Sugiyama T, Nishida T, Ushijima K, et al. Detection of lymph node metastasis in ovarian carcinoma and uterine corpus carcinoma by preoperative computerized tomography or magnetic resonance imaging. J Obstet Gynaecol. 1995;21:551-556.
22. Me-Yeon L, Hong-Gyun W, Kyubo K, et al. Concurrent radiotherapy with paclitaxel/carboplatin chemotherapy as a definitive treatment for squamous cell carcinoma of the uterine cervix. Gynecol Oncol. 2007; 104:95-99.
23. Higgins R, Bussey M, Naumann W, et al. Concurrent carboplatin and paclitaxel with pelvic radiation therapy in the primary treatment of cervical cancer. Am J Obstet Gynecol. 2007;197:205.e1-e7.
24. Rao GG, Rogers P, Drake RD, et al. Phase I clinical trial of weekly paclitaxel, weekly carboplatin, and concurrent radiotherapy for primary cervical cancer. Gyncol Oncol. 2005;96:168-172.