Rapid onset of diabetic nephropathy in three renal allografts despite normoglycemia

Clinical Nephrology

Volumn 71, Issue 6, 2009, Pages 719-724

  Wojciechowski, David ^a   Onozato, M L ^a   Gonin, J ^a  

^a GEORGETOWN UNIVERSITY HOSPITAL   (United States)

Author keywords

Diabetic nephropathy; Kidney transplant; Posttransplant diabetes mellitus

Indexed keywords

CREATININE; GLUCOSE; HEMOGLOBIN A1C; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; TACROLIMUS; DRUG DERIVATIVE; GLYCOSYLATED HEMOGLOBIN; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID;

ADULT; ARTICLE; CAPILLARY BASEMENT MEMBRANE; CASE REPORT; CREATININE BLOOD LEVEL; DIABETES MELLITUS; DIABETIC NEUROPATHY; DOSE RESPONSE; DRUG DOSE REDUCTION; DRUG TISSUE LEVEL; ELECTRON MICROSCOPY; GLOMERULOSCLEROSIS; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN TISSUE; KIDNEY ALLOGRAFT; KIDNEY BIOPSY; KIDNEY FAILURE; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; POSTTRANSPLANT DIABETES MELLITUS; PROTEIN URINE LEVEL; PROTEINURIA; SIDE EFFECT; ALLOTRANSPLANTATION; BLOOD; DIABETIC NEPHROPATHY; DRUG MONITORING; KIDNEY; METHODOLOGY; MIDDLE AGED; PATHOLOGY; POSTOPERATIVE CARE; TRANSPLANTATION;

BLOOD GLUCOSE; DIABETES MELLITUS; DIABETIC NEPHROPATHIES; DRUG MONITORING; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; MYCOPHENOLIC ACID; POSTOPERATIVE CARE; PREDNISONE; TACROLIMUS; TRANSPLANTATION, HOMOLOGOUS; TRANSPLANTS;

EID: 67651031219     PISSN: 03010430     EISSN: None     Source Type: Journal    
DOI: 10.5414/CNP71719     Document Type: Article

References (26)

1. Barosa J, Steffes MW, Sutherland DER, Connett JE, Rao V, Mauer SM. Effect of glycemic control on early diabetic renal lesions: A 5-year randomized controlled clinical trial of insulin-dependent diabetic kidney transplant recipients. JAMA. 1994; 24/31: 600-606.
2. Bhalla V, Nast CC, Stollenwerk N et al. Recurrent and de novo diabetic nephropathy in renal allografts. Transplantation. 2003; 75: 66-71.
3. Bohman SO, Tyden G, Wilczek H et al. Prevention of kidney graft diabetic nephropathy by pancreas transplantation in man. Diabetes. 1985; 34: 306-308.
4. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001; 414: 813-820.
5. Cheigh JS, Riggio RR, Stenzel KH et al. Kidney transplantation in insulin dependent diabetic patients: Improved survival and rehabilitation. Transplant Proc. 1989; 21: 2016-2017.
6. Fabrizi F, Martin P, Dixit V et al. Post-transplant diabetes mellitus and HCV seropositive status after renal transplantation: Meta-analysis of clinical studies. Am J Transplant. 2005; 5: 2433-2440.
7. Fioretto P, Steffes MW, Sutherland DER, Foetz FC, Mauer M. Reversal of lesions of diabetic nephropathy after pancreas transplantation. N Engl J Med. 1998; 339: 69-75.
8. Fioretto P, Bruseghin M, Berto I, Gallina P, Manzato E, Mussap M. Renal protection in diabetes: Role of glycemic control. J Am Soc Nephrol. 2006; 17: S86-S89.
9. Fryer JP, Granger DK, Leventhal JR, Gillingham K, Najarian JS, Matas AJ. Steroid-related complications in the cyclosporine era. Clinical Transplantation. 1994; 8: 224-229.
10. Gillison SL, Bartlett ST, Curry DL. Inhibition by cyclosporine of insulin secretion- a beta cell-specific alteration of islet tissue function. Transplantation. 1991; 52: 890-895.
11. Gnudi L, Viberti G, Raij L et al. GLUT-1 overexpression: Link between hemodynamic and metabolic factors in glomerular injury? Hypertension. 2003; 42: 19-24.
12. Goldstein DA, Massry SG. Diabetic nephropathy: Clinical course and effect of hemodialysis. Nephron. 1978; 20: 286-296.
13. Hariharan S, Smith RD, Viero R, First MR. Diabetic nephropathy after renal transplantation. Transplantation. 1996; 62: 632-635.
14. Heilig CW, Concepcion LA, Riser BL, Freytag SO, Zhu M, Cortes P. Overexpression of glucose transporters in rat mesangial cells cultured in a normal glucose milieu mimics the diabetic phenotype. J Clin Invest. 1995; 96: 1802-1814.
15. Heilig CW, Brosius FC, Henry DN. Glucose transporters of the glomerulus and the implications for diabetic nephropathy. Kidney Int. 1997; 52 (Suppl 60): S91-S99.
16. Khauli RB, Steinmuller DR, Novik AG et al. A critical look at survival of diabetics with end-stage renal disease: Transplantation versus dialysis therapy. Transplantation. 1986; 41: 598-602.
17. Kuppachi S, Idris N, Chander PN, Yoo J. Idiopathic nodular glomerulosclerosis in a non-diabetic hypertensive smoker- case report and review of literature. Nephrol Dial Transplant. 2006; 21: 3571-3575.
18. Markowitz GS, Lin J, Valerie AM et al. Idiopathic nodular glomerulosclerosis is a distinct clinicopathologic entity linked to hypertension and smoking. Hum Pathol. 2002; 33: 826-835.
19. Mauer SM, Goetz FC, McHugh LE et al. Long-term study of normal kidneys transplanted into patients with Type I diabetes. Diabetes. 1989; 38: 516-523.
20. Mayer AD, Dmitrewski J, Squifflet JP et al. Multicenter randomized trial comparing tacrolimus (FK506) and cyclosporine in the prevention of renal allograft rejection: A report of the European Tacrolimus Multicenter RenalStudyGroup.Transplantation. 1997; 64: 436-443.
21. Navaneethan SD, Singh S, Choudhry W. Nodular glomerulosclerosis in a non-diabetic patient: Case report and review of literature. J Nephrol. 2005; 18: 613-615.
22. Pirsch JD, Miller J, Deierhoi MH, Vincenti F, Filo RS. A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. FK506 Kidney Transplant Study Group. Transplantation. 1997; 63: 977-983.
23. Redmon JB, Olson LK, Armstrong MB, Greene MJ, Robertson RP. Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells. J Clin Invest. 1996; 98: 2786-2793.
24. Schena FP, Gesualdo L. Pathogenetic mechanisms of diabetic nephropathy. J Am Soc Nephrol. 2005; 16: S30-33.
25. Tuttle KR, Stein JH, DeFronzo RA. The natural history of diabetic nephropathy. Seminars in Nephrology. 1990; 10: 184-193.
26. US Renal Data System. Annual Data Report 2007. Available: http://www.usrds.org/adr.htm.