Cytotoxic and multidrug resistance reversal activity of a vegetable, 'Anastasia Red', a variety of sweet pepper

Phytotherapy Research

Volumn 17, Issue 4, 2003, Pages 348-352

  Motohashi, Noboru ^a   Wakabayashi, Hidetsugu ^b   Kurihara, Teruo ^b   Takada, Yuko ^b   Maruyama, Shichiro ^c   Sakagami, Hiroshi ^c   Nakashima, Hideki ^d   Tani, Satoru ^b   Shirataki, Yoshiaki ^b   Kawase, Masami ^b   Wolfard, Kristina ^e   Moinár, Joseph ^e  

^a MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

^b JOSAI UNIVERSITY   (Japan)

^c MEIKAI UNIVERSITY SCHOOL OF DENTISTRY   (Japan)

^d ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Anti Helicobacter pylori activity; Anti HIV activity; Capsicum annuum L. var. angulosum Mill.; Cytotoxic activity; Extracts and fractions; Multidrug resistance reversal activity

Indexed keywords

ACETONE; CLARITHROMYCIN; CURDLAN; CYTOTOXIC AGENT; DEXTRAN SULFATE; ERYTHROMYCIN; HEXANE; METHANOL; METRONIDAZOLE; OCTADECYLSILANE; SILANE DERIVATIVE; SILICA GEL; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG ISOLATION; FIBROBLAST; GINGIVA; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; MOUSE; MOUTH TUMOR; MULTIDRUG RESISTANCE; NONHUMAN; PHYTOCHEMISTRY; SQUAMOUS CELL CARCINOMA; SWEET PEPPER; T CELL LYMPHOMA; VEGETABLE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAPSICUM; CARCINOMA, SQUAMOUS CELL; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FIBROBLASTS; GINGIVA; HELICOBACTER PYLORI; HIV; HUMANS; LYMPHOMA, T-CELL; MICE; MICROBIAL SENSITIVITY TESTS; MOUTH NEOPLASMS; PHYTOTHERAPY; PLANT EXTRACTS; TUMOR CELLS, CULTURED;

CAPSICUM; CAPSICUM ANNUUM VAR. ANNUUM; HELICOBACTER PYLORI; HUMAN IMMUNODEFICIENCY VIRUS; SOLANACEAE;

EID: 0038221269     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1144     Document Type: Article

References (27)

1. de Mejía EG, Quintanar-Hernández A, Loarca-Piña G. 1998. Antimutagenic activity of carotenoids in green peppers against some nitroarenes. Mutation Res 416: 11-19.
2. Endicott JA, Ling V. 1989. The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu Rev Biochem 58: 137-171.
3. Gerlach JH, Endicott JA, Juranka PF, et al. 1986. Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance. Nature 324: 485-489.
4. Ho C. 1992. Phenolic compounds in food. In Phenolic Compounds in Food and Their Effects on Health. I. Analysis, Occurrence and Chemistry, ACS Symposium Series No. 506, Ho C, Lee CY, Huang M. (eds) American Chemical Society: Washington, DC; 1-7.
5. Hofmann A, Proust J, Dorowski A, et al. 2000. Annexin 24 from Capsicum annuum. J Biol Chem 275: 8072-8082.
6. Holland B, Welch AA, Unwin ID, et al. 1991. McCance and Widdowson's The Composition of Foods, 5th revised and extended edition. The Royal Society of Chemistry: Cambridge, and the Ministry of Agriculture, Fisheries and Food: London.
7. Juliano RL, Ling V. 1976. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 455: 152-162.
8. Kawase M, Harada H, Saito S, et al. 1999. In vitro susceptibility of Helicobacter pylori to trifluoromethyl ketones. Bioorg Med Chem Lett 9: 193-194.
9. Kessel D. 1989. Exploring multidrug resistance using rhodamine 123. Cancer Commun 1: 145-149.
10. Kuo M, Lee K, Lin J. 1992. Genotoxicities of nitropyrenes and their modulation by apigenin, tannic ellagic acid and indole-carbinol in the Salmonella and CHO system. Mutation Res 270: 87-95.
11. Lehne G. 2000. P-glycoprotein as a drug target in the treatment of multidrug resistant cancer. Current Drug Targets 1: 85-99.
12. Mejía LA, Hudson E, de Mejía G, Vázquez F. 1988. Carotenoid content and vitamin A activity of some common cultivars of Mexican peppers (Capsium annuum) as determined by HPLC. J Food Sci 53: 1448-1451.
13. Møller A. 1989. Food composition Tables 1989. Nutrient Composition of Danish Foods. National Food Agency: Søborg, Denmark.
14. Molnár J, Szabó, Pusztai R, et al. 2000. Membrane associated antitumor effects of crocine-, ginsenosides- and cannabinoid derivatives. Anticancer Res 20: 861-868.
15. Molnár J, Mucsi I, Hofmann J, et al. 2001. New compounds to reverse multidrug resistance of cancer cells. Anticancer Res 21: 1603.
16. Motohashi N, Kurihara T, Wakabayashi H, et al. 2001. Biological activity of a vegetable 'Anastasia Green', a species of sweet pepper. In vivo 15: 437-442.
17. Nakashima H, Murakami T, Yamamoto N, et al. 1992. Inhibition of human immunodeficiency viral replication by tannins and related compounds. Antiviral Res 18: 91-103.
18. Numao N, Iwahori A, Hirota Y, et al. 1997. Antibacterial activity of two alkylamines integrated an indane scaffold: mimicry of a complementary unit on magainin 2. Biol Pharm Bull 20: 800-804.
19. Odin AP. 1997. Vitamins as antimutagens: advantages and some possible mechanisms of antimutagenic action. Mutation Res 386: 39-67.
20. Pastan I, Gottesman MM, Ueda K, et al. 1988. A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells. Proc Natl Acad Sci USA 85: 4486-4490.
21. Petersen MA, Berends H. 1993. Ascorbic acid and dehydro-ascorbic acid content of blanched sweet green pepper during chilled storage in modified atmospheres. Z. Lebensm. Unters Forsch 197: 546-549.
22. Rand JH. 2000. The annexinopathies: a new category of diseases. Biochim Biophys Acta 1498: 169-173.
23. Sakagami H, Jiang Y, Kusama K, et al. 2000. Cytotoxic activity of hydrolyzable tannins against human oral tumor cell lines. A possible mechanism. Phytomedicine 7: 39-47.
24. Stavric B. 1994. Antimutagens and anticarcinogens in foods. Food Chem Toxicol 32: 79-90.
25. Szabó D, Keyzer H, Kaiser H, Molnár J. 2000. Reversal of multidrug resistance of tumor cells. Anticancer Res 20: 4261-4274.
26. Weaver JL, Szabo G, Pine PS, et al. 1993. The effect of ion channel blockers, immunosuppressive agents, and other drugs on the activity of the multi-drug transporter. Int J Cancer 54: 456-461.
27. +-dependent D-glucose uptake in rat intestinal brush border membrane vesicles. J Nutr 119: 1698-1704.