Patterns of local recurrence in locally advanced rectal cancer after intra-operative radiotherapy containing multimodality treatment

Radiotherapy and Oncology

Volumn 92, Issue 2, 2009, Pages 221-225

  Kusters, Miranda ^a,b   Holman, Fabian A ^b   Martijn, Hendrik ^b   Nieuwenhuijzen, Grard A ^b   Creemers, Geert Jan ^b   Daniels Gooszen, Alette W ^b   van den Berg, Hetty A ^b   van den Brule, Adriaan J ^b   van de Velde, Cornelis J H ^a   Rutten, Harm J T ^b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b CATHARINA HOSPITAL   (Netherlands)

Author keywords

Intra operative radiotherapy; Local recurrence; Locally advanced rectal carcinoma; Radical resection

Indexed keywords

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER DIAGNOSIS; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER REGRESSION; CANCER STAGING; CANCER SURGERY; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DISTANT METASTASIS; DOSIMETRY; DRUG TARGETING; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRAOPERATIVE RADIOTHERAPY; MAJOR CLINICAL STUDY; MALE; MULTIMODALITY CANCER THERAPY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RECTUM CANCER; RISK FACTOR; SURGICAL TECHNIQUE; TREATMENT DURATION; TREATMENT OUTCOME; TUMOR CLASSIFICATION; TUMOR LOCALIZATION;

ADULT; AGED; AGED, 80 AND OVER; COMBINED MODALITY THERAPY; FEMALE; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM RECURRENCE, LOCAL; RECTAL NEOPLASMS;

EID: 67650941737     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2009.03.002     Document Type: Article

References (19)

1. Sauer R., Becker H., Hohenberger W., Rodel C., Wittekind C., Fietkau R., et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351 (2004) 1731-1740
2. Valentini V., Coco C., Picciocchi A., Morganti A.G., Trodella L., Ciabattoni A., et al. Does downstaging predict improved outcome after preoperative chemoradiation for extraperitoneal locally advanced rectal cancer? A long-term analysis of 165 patients. Int J Radiat Oncol Biol Phys 53 (2002) 664-674
3. Braendengen M., Tveit K.M., Berglund A., Birkemeyer E., Frykholm G., Pahlman L., et al. Randomized phase III study comparing preoperative radiotherapy with chemoradiotherapy in nonresectable rectal cancer. J Clin Oncol 26 (2008) 3687-3694
4. Mannaerts G.H., Martijn H., Crommelin M.A., Dries W., Repelaer van Driel O.J., and Rutten H.J. Feasibility and first results of multimodality treatment, combining EBRT, extensive surgery, and IOERT in locally advanced primary rectal cancer. Int J Radiat Oncol Biol Phys 47 (2000) 425-433
5. Azinovic I., Calvo F.A., Puebla F., Aristu J., and Martinez-Monge R. Long-term normal tissue effects of intraoperative electron radiation therapy (IOERT): late sequelae, tumor recurrence, and second malignancies. Int J Radiat Oncol Biol Phys 49 (2001) 597-604
6. Gunderson L.L. Past, present, and future of intraoperative irradiation for colorectal cancer. Int J Radiat Oncol Biol Phys 34 (1996) 741-744
7. Gunderson L.L., Nelson H., Martenson J.A., Cha S., Haddock M.G., Devine R.M., et al. Locally advanced primary colorectal cancer: IOERT and EBRT +/-5-FU. Front Radiat Ther Oncol 31 (1997) 204-208
8. Calvo F.A., Gomez-Espi M., az-Gonzalez J.A., Alvarado A., Cantalapiedra R., Marcos P., et al. Intraoperative presacral electron boost following preoperative chemoradiation in T3-4Nx rectal cancer: initial local effects and clinical outcome analysis. Radiother Oncol 62 (2002) 201-206
9. Roeder F., Treiber M., Oertel S., Dinkel J., Timke C., Funk A., et al. Patterns of failure and local control after intraoperative electron boost radiotherapy to the presacral space in combination with total mesorectal excision in patients with locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 67 (2007) 1381-1388
10. Mannaerts G.H., Rutten H.J., Martijn H., Groen G.J., Hanssens P.E., and Wiggers T. Abdominosacral resection for primary irresectable and locally recurrent rectal cancer. Dis Colon Rectum 44 (2001) 806-814
11. Gosens M.J., Klaassen R.A., Tan-Go I., Rutten H.J., Martijn H., van den Brule A.J., et al. Circumferential margin involvement is the crucial prognostic factor after multimodality treatment in patients with locally advanced rectal carcinoma. Clin Cancer Res 13 (2007) 6617-6623
12. Putter H., Fiocco M., and Geskus R.B. Tutorial in biostatistics: competing risks and multi-state models. Stat Med 26 (2007) 2389-2430
13. Krempien R., Roeder F., Oertel S., Roebel M., Weitz J., Hensley F.W., et al. Long-term results of intraoperative presacral electron boost radiotherapy (IOERT) in combination with total mesorectal excision (TME) and chemoradiation in patients with locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 66 (2006) 1143-1151
14. Diaz-Gonzalez J.A., Calvo F.A., Cortes J., de La M.D., Gomez-Espi M., Lozano M.A., et al. Preoperative chemoradiation with oral tegafur within a multidisciplinary therapeutic approach in patients with T3-4 rectal cancer. Int J Radiat Oncol Biol Phys 61 (2005) 1378-1384
15. Roels S., Duthoy W., Haustermans K., Penninckx F., Vandecaveye V., Boterberg T., et al. Definition and delineation of the clinical target volume for rectal cancer. Int J Radiat Oncol Biol Phys 65 (2006) 1129-1142
16. Syk E., Torkzad M.R., Blomqvist L., Nilsson P.J., and Glimelius B. Local recurrence in rectal cancer: anatomic localization and effect on radiation target. Int J Radiat Oncol Biol Phys 72 (2008) 658-664
17. Kusters M., Beets G.L., van de Velde C.J., Beets-Tan R.G., Marijnen C.A., Rutten H., et al. A comparison between the treatment of low rectal cancer in Japan and the Netherlands, with focus on the patterns of local recurrence. Ann Surg 249 (2009) 229-235
18. Kusters M., van de Velde C.J., Beets-Tan R.G., Akasu T., Fujita S., Yamamoto S., et al. Patterns of local recurrence in rectal cancer: a single-center experience. Ann Surg Oncol 16 (2009) 289-296
19. Steup W.H., Moriya Y., and van de Velde C.J. Patterns of lymphatic spread in rectal cancer. A topographical analysis on lymph node metastases. Eur J Cancer 38 (2002) 911-918