Feasibility and first results of multimodality treatment, combining EBRT, extensive surgery, and IOERT in locally advanced primary rectal cancer

International Journal of Radiation Oncology Biology Physics

Volumn 47, Issue 2, 2000, Pages 425-433

  Mannaerts, Guido H H ^a   Martijn, Hendrik ^a   Crommelin, Mariad A ^a   Dries, Wim ^a   Repelaer Van Driel, Ocker J ^b   Rutten, Harm J T ^a  

^a CATHARINA HOSPITAL   (Netherlands)

^b Colo Rectal Tum Grp ^*  (Netherlands)

Author keywords

EBRT; Intraoperative radiotherapy; IOERT; IORT; Primary locally advanced rectal cancer; Surgery

Indexed keywords

ADULT; ADVANCED CANCER; AGED; ARTICLE; BEAM THERAPY; CANCER RADIOTHERAPY; CANCER SURGERY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; INTRAOPERATIVE PERIOD; MALE; MULTIMODALITY CANCER THERAPY; PRIORITY JOURNAL; PROGNOSIS; RECTUM CANCER; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; COMBINED MODALITY THERAPY; ELECTRONS; FEASIBILITY STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; NEOPLASM, RESIDUAL; POSTOPERATIVE COMPLICATIONS; RADIOTHERAPY DOSAGE; RECTAL NEOPLASMS; REOPERATION;

EID: 0034194094     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(99)00492-7     Document Type: Article

References (53)

1. Gunderson L.L., Tepper J.E., Dosoretz D.E. Patterns of failure after treatment of gastrointestinal cancer. Cancer Treat Symposia. 2:1983;181-197.
2. Stevens K.R., Allen C.V., Fletcher W.S. Preoperative radiotherapy for adenocarcinoma of the rectosigmoid. Cancer. 37:1976;2866-2874.
3. Stevens K.R., Fletcher W.S. High dose preoperative pelvic irradiation for unresectable adenocarcinoma of the rectum or sigmoid. Int J Radiat Oncol Biol Phys. 9:1983;148.
4. Emami B., Pilepich M., Willet C., Munzenrider J.E., Miller H.H. Management of unresectable colorectal carcinoma (preoperative radiotherapy and surgery). Int J Radiat Oncol Biol Phys. 8:1982;1295-1299.
5. Dosoretz D.E., Gunderson L.L., Hedberg S., Hoskins B., Blitzer P.H., Shipley W., Cohen A. Preoperative irradiation for localized carcinoma of the rectum and rectosigmoid patterns of failure, survival and future treatment strategies . Cancer. 52:1983;814-818.
6. Mendenhall W.M., Million R.R., Bland K.I., Pfaff W.W., Copeland E.M. Initially unresectable rectal adenocarcinoma treated with preoperative irradiation and surgery. Ann Surg. 205:1987;41-44.
7. Gunderson L.L., Russell A.H., Llewellyn H.T., Doppke K.P., Tepper J.E. Treatment planning for colorectal cancer radiation and surgical techniques and value of small bowel films . Int Radiat Oncol Biol Phys. 11:1985;1379-1393.
8. Gunderson L.L., Martinson J.A. Gastrointestinal tract radiation tolerance. Front Radiat Ther Oncol. 23:1989;2777-3298.
9. Sindelar W.F., Johnstone P.A.S., Hoekstra H.J., Kinsella T.J. Normal tissue tolerance to intraoperative irradiation. Gunderson L.L., Willett C.G., Harrison L.B., Calvo F.A. Intraoperative irradiation techniques and results (first ed.) . 1999;131-146 Humana Press Inc, Totowa, NJ.
10. Gunderson L.L., Martin J.K., Beart R.W., Nagorney D.M., Fieck J.M., Wieand H.S., Martinez A., O'Connell M.J., Martenson J.A., McIlrath D.C. Intraoperative and external beam irradiation for locally advanced colorectal cancer. Ann Surg. 207:1988;52-60.
11. Gunderson L.L. Past, present, and future of intraoperative irradiation for colorectal cancer. Int J Radiat Oncol Biol Phys. 34:1996;741-744.
12. Gunderson L.L., Nelson H., Martinson J.A., Cha S., Haddock M., Devine R., Fieck J.M., Wolff B., Dozois R., O'Connell M.J. Locally advanced primary colorectal cancer; Intraoperative electron and external beam irradiation ± 5-FU. Int J Radiat Oncol Biol Phys. 37:1997;601-614.
13. Tepper J.E., Wood W.C., Cohen A.M. Treatment of locally advanced rectal cancer with external beam radiation, surgical resection, and intraoperative radiation therapy. Int J Radiat Oncol Biol Phys. 16:1989;1437-1444.
14. Huber F.T., Stepan R., Zimmermann F., Fink U., Molls M., Siewert J.R. Locally advanced rectal cancer resection and intraoperative radiation therapy using the flab method combined with preoperative or postoperative radiochemotherapy . Dis Colon Rectum. 39:1996;774-779.
15. Willett C.G., Shellito P.C., Tepper J.E., Eliseo R., Convery K., Wood W.C. Intraoperative electron beam radiation therapy for primary locally advanced rectal and rectosigmoid carcinoma. J Clin Oncol. 9:1991;843-849.
16. Eble M.J., Kallinowski F., Wannenmacher M.F., Herlach C. Intraoperative radiotherapie des lokal ausgedehnten und rezidivierten rectumcarcinoms. Chirurg. 65:1994;585-592.
17. Suzuki K., Gunderson L.L., Devine R.M., Weaver A.L., Dozois R.R., Ilstrup D.M., Martenson J.A., O'Connell M.J. Intraoperative irradiation after palliative surgery for locally recurrent rectal cancer. Cancer. 75:1995;939-952.
18. Martijn H., de Neve W., Lybeert M.L.M., Crommelin M.A., Ribot J.G. Adjuvant postoperative radiotherapy for adenocarcinoma of the rectum and rectosigmoid. A retrospective analysis of locoregional control, survival, and prognostic factors on 178 patients. Am J Clin Oncol (CCT). 18:1995;277-281.
19. Prescribing, recording and reporting photon beam therapy. ICRU-report 50, 1993. 1993;ICRU, Bethesda, MD.
20. Gunderson LL, Noyes D, Kvols L. Radiation Therapy Oncology Group (RTOG) protocol 88-20. Phase III protocol for the treatment of residual or unresectable carcinoma of the rectum and rectosigmoid or pelvic recurrence following primary colorectal resection: External beam radiation therapy + 5-fluorouracil/leucovorin with or without IORT electron boost. 1990.
21. Cox J.D., Stetz J., Pajak T.F. Toxity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys. 31:1995;1341-1346.
22. Gunderson L.L., Calvo F.A., Willett C.G., Harrison L.B., Santos M. General rationale and historic perspective of intraoperative irradiation. Gunderson L.L., Willett C.G., Harrison L.B., Calvo F.A. Intraoperative irradiation; techniques and results (first ed). 1999;1-24 Humana Press Inc, Totowa.
23. Mohiuddin M., Marks G. High dose preoperative irradiation for cancer of the rectum. Int J Radiat Oncol Biol Phys. 20:1991;37-43.
24. Higgens G.A., Humphrey E.W., Dwight R.W., Roswit B., Lee L.E., Keehn R.J. Preoperative radiation and surgery for cancer of the rectum. Veterans Administration Surgical Oncology Group trial II. Cancer. 58:1986;352-359.
25. Pilepich M.V., Munzenrider J.E., Tak W.K., Miller H.H. Preoperative irradiation of primary unresectable colorectal cancer. Cancer. 42:1978;1077-1081.
26. Buhre L.M.D., Mulder N.H., Oldhoff J., Szabó B.G., Grond A.J., Verschueren R.C. Local control in advanced rectal cancer the clinical staging of rectal cancer in patients treated by preoperative radiotherapy . Clin Oncol. 6:1994;157-161.
27. Minsky B.D., Cohen A.M., Enker W.E., Kelsen D.P., Kemeny N., Riechman B., Salz L., Sigurdson E.R., Frankel J. Phase I trail of postoperative 5 FU, radiation therapy and high dose leucovorin for resectable rectal cancer. Int J Radiat Oncol Biol Phys. 22:1991;139-145.
28. Minsky B., Cohen A.M., Kemeny N., Enker W.E., Kelsen D.P., Satz L., Frankel J. The efficacy of preoperative 5-FU, high dose leucovorin, and sequential radiotherapy for unresectable rectal cancer. Cancer. 71:1993;3486-3492.
29. Martenson J.A., Schield S.E. External radiation therapy for primary locally advanced rectal cancer. Cohen A.M., Winawer S.J., Friedman M.A., Gunderson L.L. Cancer of the colon, rectum and anus. 1995;695-701 McGraw-Hill, New York.
30. Neve de W., Martijn H., Lybeert M.M., Crommelin M., Goor Ch, Ribot J.G. Incompletely resected rectum, recto-sigmoid, or sigmoid carcinoma results of postoperative radiotherapy and prognostic factors . Int J Radiat Oncol Biol Phys. 21:1991;1297-1302.
31. Allee P.E., Tepper J.E., Gunderson L.L., Munzenrider J.E. Postoperative radiation therapy for incompletely resected colorectal carcinoma. Int J Radiat Oncol Biol Phys. 17:1989;1171-1176.
32. Gillette E.L., Gillette S.M., Powers B.E., Thames H.D. Potential for therapeutic gain for IORT combined with EBRT. Abe M., Takahashi M. Intraoperative radiotherapy. 1991;12-14 Pergamon Press, Elmsford.
33. Suit H.D. Radiation biology a basis for radiotherapy . Fletcher G.H. Textbook of Radiotherapy (second ed). 1973;75-121 Lea and Febiger, Philadelphia.
34. Willett C.G., Shellito P.C., Gunderson L.L. Primary colorectal EBRT and IOERT. Gunderson L.L., Willett C.G., Harrison L.B., Calvo F.A. Intraoperative irradiation techniques and results (first ed) . 1999;249-272 Humana Press Inc, Totowa, NJ.
35. Tepper J.E., Cohen A.M., Wood W.C., Hedberg S.E., Orlow E. Intraoperative electron beam radiotherapy of unresectable rectal cancer. Arch Surg. 121:1986;421-423.
36. Calvo F.A., Santos M., Brady L.W. Intraoperative Radiotherapy. Clinical experiences and results. 1992;Springer-Verlag, Berlin.
37. Eble M.J., Kallinowski F., Wulf J., Lehnert Th, Weischedel U., Herfarth C., Wannenmacher M. Moderate-Dose IORT and external beam radiotherapy in locally advanced or recurrent rectal carcinoma. Hepatogastrenterology. 41:1994;21.
38. Kinsella T.J., Sindelar W.F., Deluca A.M., Pezeshkpour G., Smith R., Maher M., Terrill R., Miller R., Mixon A., Harwell J.F., Rosenberg S.A., Glatstein E. Tolerance of peripheral nerve to intraoperative radiotherapy (IORT) clinical and experimental studies . Int J Radiat Oncol Biol Phys. 11:1985;1579-1585.
39. Haddock MG. Intraoperative radiotherapy (IORT) in locally advanced primary and recurrent rectal cancer. The Mayo clinic experience. Third TME-workshop, 1997, Catharina Hospital, Eindhoven, The Netherlands.
40. Farouk R., Nelson H., Gunderson L. Aggressive treatment for locally advanced irresectable rectal cancer. Br J Surg. 84:1997;741-749.
41. Kim H.K., Jessup J.M., Beard C.J., Bornstein B., Cady B., Stone M.D., Bleday R., Bothe A., Steele G., Busse P.M. Locally advanced rectal carcinoma pelvic control and morbidity following preoperative radiation therapy, resection, and intraoperative radiation therapy . Int J Radiat Oncol Biol Phys. 38:1997;777-783.
42. Tveit K.M., Wiig J.N., Olsen D.R., Storaas A., Poulsen J.P., Giercksky K.E. Combined modality treatment including intraoperative radiotherapy in locally advanced and recurrent rectal cancer. Radioth Oncol. 44:1997;277-282.
43. Minsky B.D., Cohen A.M., Kemeny N., Enker W.E., Kelsen D.P., Reichman B., Saltz L., Sigurdson E.R., Frankel J. Enhancement of radiation-induced downstaging of rectal cancer by fluorouracil and high-dose leucovorin chemotherapy. J Clin Oncol. 10:1992;79-84.
44. Willett C.G., Nakfoor B.K., Daley W., Shellito P.C. Pathological downstaging does not guide the need for IORT in primary locally advanced rectal cancer. Front Radiat Ther Oncol. 31:1997;245-246.
45. Calvo F.A., Cantalapiedra R., Marcos P., Del Valle E., Munoz F., Garcia-Sabrido J.L., Gomez M., Lozano M.A. Preoperative chemoradiation plus intraoperative presacral electrons in T3-4 Nx M0 primary rectal cancer early single intitution experience . Eur J Cancer. 35:(Suppl. 4):1999;S73.
46. Graf W., Dahlberg M., Osman M.M., Holmberg L., Pahlman L., Glimelius B. Short-term preoperative radiotherapy results in down-staging of rectal cancer a study of 1316 patients . Radiother Oncol. 43:1997;133-137.
47. Francois Y., Nemoz C.J., Baulieux J., Vignal J., Grandjean J.P., Partensky C., Souquet J.C., Adeline P., Gerard J.P. Influence of the interval between preoperative radiation therapy and surgery on downstaging and the rate of sphincter-sparing surgery for rectal cancer the Lyon R90-01 randomized trial . J Clin Oncol. 17:1999;2396-2402.
48. Randomized trial of surgery alone versus radiotherapy followed by surgery for potentially operable locally advanced rectal cancer. Lancet. 348:1996;1605-1610.
49. Mohiuddin M., Marks G. High dose preoperative irradiation for cancer of the rectum, 1976-1988. Int J Radiat Oncol Biol Phys. 20:1990;37-43.
50. Eble M.J., Lehhnert T., Herfarth Ch, Wannenmacher M. IORT as adjuvant treatment in primary rectal carcinomas multi-modality treatment . Front Radiat Ther Oncol. 31:1997;200-203.
51. Frykholm G., Glimelius B., Pahlman L. Preoperative irradiation with and without chemotherapy (MRL) in the treatment of primary non-resectable adenocarcinoma of the rectum. Eur J Cancer Clin Oncol. 25:1989;1535-1541.
52. Shumate C., Rich T., Skibber J.M., Ajani J.A., Ota D.M. Preoperative chemotherapy and radiation therapy for locally advanced primary and recurrent rectal carcinoma. Cancer. 71:1993;3690-3696.
53. Schild S.E., Gunderson L.L., Haddock M.G., Wong W.W., Nelson H. The treatment of locally advanced colon cancer. Int Radiat Oncol Biol Phys. 37:1997;51-58.