Overexpression of the Fas-inhibitory molecule TOSO - A novel antiapoptotic factor in chronic lymphocytic leukemia

Leukemia and Lymphoma

Volumn 50, Issue 3, 2009, Pages 498-501

  Pallasch, Christian Philipp ^a   Wendtner, Clemens Martin ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Apoptosis; Chronic lymphocytic leukemia; FAIM3; Fas; TOSO

Indexed keywords

APOPTOSIS INHIBITOR; B LYMPHOCYTE RECEPTOR; BH3 PROTEIN; CD38 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; FAS ANTIGEN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; IMMUNOGLOBULIN HEAVY CHAIN; MEMBRANE PROTEIN; PROTEIN BID; TOSO PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER STAGING; CARBOXY TERMINAL SEQUENCE; CHRONIC LYMPHATIC LEUKEMIA; CYTOLOGY; DISEASE COURSE; DRUG TARGETING; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE MUTATION; GENE OVEREXPRESSION; GENE THERAPY; HUMAN; INHIBITION KINETICS; LEUKEMOGENESIS; LEUKOCYTE COUNT; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BINDING; PROTEIN DOMAIN; RECEPTOR UPREGULATION; SENSITIZATION; SIGNAL TRANSDUCTION;

APOPTOSIS REGULATORY PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MEMBRANE PROTEINS; NEOPLASM PROTEINS;

EID: 67650899293     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.1080/10428190902763491     Document Type: Article

References (13)

1. de Totero, D., Montera, M., Rosso, O., Clavio, M., Balleari, E. Foa, R. et al. (2004) Resistance to CD95-mediated apoptosis of CD40-activated chronic lymphocytic leukemia B cells is not related to lack of DISC molecules expression. Hematol J, 5, pp. 152-160.
2. Romano, C., De Fanis, U., Sellitto, A., Chiurazzi, F., Guastafierro, S. Giunta, R. et al. (2005) Induction of CD95 upregulation does not render chronic lymphocytic leukemia B-cells susceptible to CD95-mediated apoptosis. Immunol Lett, 97, pp. 131-139.
3. Chu, P., Deforce, D., Pedersen, I. M., Kim, Y., Kitada, S. Reed, J. C. et al. (2002) Latent sensitivity to Fas-mediated apoptosis after CD40 ligation may explain activity of CD154 gene therapy in chronic lymphocytic leukemia. Proc Natl Acad Sci USA, 99, pp. 3854-3859.
4. Hitoshi, Y., Lorens, J., Kitada, S. I., Fisher, J., LaBarge, M. Ring, H. Z. et al. (1998) Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells. Immunity, 8, pp. 461-471.
5. Pallasch, C. P., Schulz, A., Kutsch, N., Schwamb, J., Hagist, S. Kashkar, H. et al. (2008) Overexpression of TOSO in CLL is triggered by B-cell receptor signaling and associated with progressive disease. Blood, 112, pp. 4213-4219.
6. Song, Y. and Jacob, C. O. (2005) The mouse cell surface protein TOSO regulates Fas/Fas ligand-induced apoptosis through its binding to Fas-associated death domain. J Biol Chem, 280, pp. 9618-9926.
7. Rosenwald, A., Alizadeh, A. A., Widhopf, G., Simon, R., Davis, R. E. Yu, X. et al. (2001) Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med, 194, pp. 1639-1647.
8. Proto-Siqueira, R., Panepucci, R. A., Careta, F. P., Lee, A., Clear, A. Morris, K. et al. (2008) SAGE analysis demonstrates increased expression of TOSO contributing to Fas-mediated resistance in CLL. Blood, 112, pp. 394-397.
9. Damle, R. N., Temburni, S., Calissano, C., Yancopoulos, S., Banapour, T. Sison, C. et al. (2007) CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells. Blood, 110, pp. 3352-3359.
10. Herve, M., Xu, K., Ng, Y. S., Wardemann, H., Albesiano, E. Messmer, B. T. et al. (2005) Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity. J Clin Invest, 115, pp. 1636-1643.
11. Kater, A. P., Dicker, F., Mangiola, M., Welsh, K., Houghten, R. Ostresh, J. et al. (2005) Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis. Blood, 106, pp. 1742-1748.
12. Lanemo Myhrinder, A, Hellqvist, E., Sidorova, E., Soderberg, A., Baxendale, H. Dahle, C. et al. (2008) A new perspective: Molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies. Blood, 111, pp. 3838-3848.
13. Pallasch, C. P., Schwamb, J., Königs, S., Schulz, A., Debey, S. Kofler, D. et al. (2008) Targeting lipid metabolism by the lipoprotein lipase inhibitor orlistat results in apoptosis of B-cell chronic lymphocytic leukemia cells. Leukemia, 22, pp. 585-592.