Mesencephalic astrocyte-derived neurotrophic factor reduces ischemic brain injury and promotes behavioral recovery in rats

Journal of Comparative Neurology

Volumn 515, Issue 1, 2009, Pages 116-124

  Airavaara, Mikko ^a   Shen, Hui ^a   Kuo, Chi Chung ^a   Peränen, Johan ^b   Saarma, Mart ^b   Hoffer, Barry ^a   Wang, Yun ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Armet; Ischemia; Stroke

Indexed keywords

CALCIUM ION; MESENCEPHALIC ASTROCYTE DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIC FACTOR; POTASSIUM ION; SODIUM ION; TRIPHENYLTETRAZOLIUM; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; BLOOD GAS; BLOOD PRESSURE; BRAIN BLOOD FLOW; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN PROTECTION; CELL DEATH; CONFERENCE PAPER; CONTROLLED STUDY; ELECTROLYTE BLOOD LEVEL; LOCOMOTION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; BEHAVIOR, ANIMAL; BRAIN; BRAIN INFARCTION; CYTOPROTECTION; DISEASE MODELS, ANIMAL; HUMANS; HYPOXIA-ISCHEMIA, BRAIN; INDICATORS AND REAGENTS; MALE; MOTOR ACTIVITY; NECROSIS; NERVE DEGENERATION; NERVE TISSUE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; RECOVERY OF FUNCTION; STAINING AND LABELING; TETRAZOLIUM SALTS; TREATMENT OUTCOME;

EID: 67650899072     PISSN: 00219967     EISSN: 10969861     Source Type: Journal    
DOI: 10.1002/cne.22039     Document Type: Conference Paper

References (36)

1. Airaksinen MS, Saarma M. 2002. The GDNF family: signalling, biological functions and therapeutic value. Nat Rev Neurosci 3:383-394.
2. Apostolou A, Shen Y, Liang Y, Luo J, Fang S. 2008. Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death. Exp Cell Res (in press).
3. Arvidsson A, Kokaia Z, Airaksinen MS, Saarma M, Lindvall O. 2001. Stroke induces widespread changes of gene expression for glial cell linederived neurotrophic factor family receptors in the adult rat brain. Neuroscience 106:27-41.
4. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H. 1986. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17(3):472-476.
5. Borlongan CV, Hida H, Nishino H. 1998. Early assessment of motor dysfunctions aids in successful occlusion of the middle cerebral artery. Neuroreport 9(16):3615-3621.
6. Chang CF, Lin SZ, Chiang YH, Morales M, Chou J, Lein P, Chen HL, Hoffer BJ, Wang Y. 2003. Intravenous administration of bone morphogenetic protein-7 after ischemia improves motor function in stroke rats. Stroke 34:558-564.
7. Chen ST, Hsu CY, Hogan EL, Maricq H, Balentine JD. 1986. A model of focal ischemic stroke in the rat: reproducible extensive cortical infarction. Stroke 17:738-743.
8. Chiang YH, Lin SZ, Borlongan CV, Hoffer BJ, Morales M, Wang Y. 1999. Transplantation of fetal kidney tissue reduces cerebral infarction induced by middle cerebral artery ligation. J Cereb Blood Flow Metab 19:1329-1335.
9. Chou J, Harvey BK, Chang CF, Shen H, Morales M, Wang Y. 2006. Neuroregenerative effects of BMP7 after stroke in rats. J Neurol Sci 240:21-29.
10. Cox S, Harvey BK, Sanchez JF, Wang JY, Wang Y. 2004. Mediation of BMP7 neuroprotection by MAPK and PKC IN rat primary cortical cultures. Brain Res 1010:55-61.
11. DeGracia DJ, Montie HL. 2004. Cerebral ischemia and the unfolded protein response. J Neurochem 91:1-8.
12. Harvey BK, Chang CF, Chiang YH, Bowers WJ, Morales M, Hoffer BJ, Wang Y, Federoff HJ. 2003. HSV amplicon delivery of glial cell line-derived neurotrophic factor is neuroprotective against ischemic injury. Exp Neurol 183:47-55.
13. Harvey BK, Mark A, Chou J, Chen GJ, Hoffer BJ, Wang Y. 2004. Neurotrophic effects of bone morphogenetic protein-7 in a rat model of Parkinson's disease. Brain Res 1022:88-95.
14. Harvey BK, Hoffer BJ, Wang Y. 2005. Stroke and TGF-beta proteins: glial cell line-derived neurotrophic factor and bone morphogenetic protein. Pharmacol Ther 105:113-125.
15. Lin SZ, Hoffer BJ, Kaplan P, Wang Y. 1999. Osteogenic protein-1 protects against cerebral infarction induced by MCA ligation in adult rats. Stroke 30:126-133.
16. Lindholm D, Wootz H, Korhonen L. 2006. ER stress and neurodegenerative diseases. Cell Death Differ 13:385-392.
17. Lindholm P, Voutilainen MH, Lauren J, Peränen J, Leppänen VM, Andressoo JO, Lindahl M, Janhunen S, Kalkkinen N, Timmusk T, Tuominen RK, Saarma M. 2007. Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. Nature 448:73-77.
18. Lindholm P, Peränen J, Andressoo JO, Kalkkinen N, Kokaia Z, Lindvall O, Timmusk T, Saarma M. 2008. MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain. Mol Cell Neurosci 39:356-371.
19. Luo Y, Kuo C, Shen H, Greig N, Hoffer B. 2008. Delayed treatment with a p53 inhibitor enhances recovery in stroke brain. Ann Neurol (in press).
20. Miyazaki H, Nagashima K, Okuma Y, Nomura Y. 2001. Expression of glial cell line-derived neurotrophic factor induced by transient forebrain ischemia in rats. Brain Res 922:165-172.
21. Mizobuchi N, Hoseki J, Kubota H, Toyokuni S, Nozaki J, Naitoh M, Koizumi A, Nagata K. 2007. ARMET is a soluble ER protein induced by the unfolded protein response via ERSE-II element. Cell Struct Funct 32: 41-50.
22. Peränen J, Furuhjelm J. 2001. Expression, purification, and properties of Rab8 function in actin cortical skeleton organization and polarized transport. Methods Enzymol 329:188-196.
23. Peränen J, Rikkonen M, Hyvönen M, Kääriäinen L. 1996. T7 vectors with modified T7lac promoter for expression of proteins in Escherichia coli. Anal Biochem 236:371-373.
24. Petrova P, Raibekas A, Pevsner J, Vigo N, Anafi M, Moore MK, Peaire AE, Shridhar V, Smith DI, Kelly J, Durocher Y, Commissiong JW. 2003. MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons. J Mol Neurosci 20:173-188.
25. Ren J, Kaplan PL, Charette MF, Speller H, Finklestein SP. 2000. Time window of intracisternal osteogenic protein-1 in enhancing functional recovery after stroke. Neuropharmacology 39:860-865.
26. Ron D, Walter P. 2007. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8:519-529.
27. Shridhar R, Shridhar V, Rivard S, Siegfried JM, Pietraszkiewicz H, Ensley J, Pauley R, Grignon D, Sakr W, Miller OJ, Smith DI. 1996a. Mutations in the arginine-rich protein gene, in lung, breast, and prostate cancers, and in squamous cell carcinoma of the head and neck. Cancer Res 56:5576-5578.
28. Shridhar V, Rivard S, Shridhar R, Mullins C, Bostick L, Sakr W, Grignon D, Miller OJ, Smith DI. 1996b. A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas. Oncogene 12:1931-1939.
29. Slivka A, Murphy E, Horrocks L. 1995. Cerebral edema after temporary and permanent middle cerebral artery occlusion in the rat. Stroke 26:1061 1065; discussion 1065-1066.
30. Tomac AC, Agulnick AD, Haughey N, Chang CF, Zhang Y, Backman C, Morales M, Mattson MP, Wang Y, Westphal H, Hoffer BJ. 2002. Effects of cerebral ischemia in mice deficient in Persephin. Proc Natl Acad Sci U S A 99:9521-9526.
31. Wang Y, Chang CF, Morales M, Chou J, Chen HL, Chiang YH, Lin SZ, Cadet JL, Deng X, Wang JY, Chen SY, Kaplan PL, Hoffer BJ. 2001. Bone morphogenetic protein-6 reduces ischemia-induced brain damage in rats. Stroke 32:2170-2178.
32. Wang Y, Chang CF, Morales M, Chiang YH, Harvey BK, Su TP, Tsao LI, Chen S, Thiemermann C. 2003. Diadenosine tetraphosphate protects against injuries induced by ischemia and 6-hydroxydopamine in rat brain. J Neurosci 23:7958-7965.
33. Yonemori F, Yamaguchi T, Yamada H, Tamura A. 1999. Spatial cognitive performance after chronic focal cerebral ischemia in rats. J Cereb Blood Flow Metab 19:483-494.
34. Yu LY, Saarma M, Arumae U. 2008. Death receptors and caspases but not mitochondria are activated in the GDNF- or BDNF-deprived dopaminergic neurons. J Neurosci 28:7467-7475.
35. Zhang WR, Sato K, Iwai M, Nagano I, Manabe Y, Abe K. 2002. Therapeutic time window of adenovirus-mediated GDNF gene transfer after transient middle cerebral artery occlusion in rat. Brain Res 947:140-145.
36. Zhou C, Xiao C, Commissiong JW, Krnjevic K, Ye JH. 2006. Mesencephalic astrocyte-derived neurotrophic factor enhances nigral gamma-aminobutyric acid release. Neuroreport 17:293-297.