Inhibitor of apoptosis (IAP) proteins: Novel insights into the cancer-relevant targets for cell death induction

ACS Chemical Biology

Volumn 4, Issue 7, 2009, Pages 499-501

  Fulda, Simone ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 9; INHIBITOR OF APOPTOSIS PROTEIN; UBIQUITIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CELL DEATH; GENE CONTROL; GENE EXPRESSION; GENE TARGETING; HUMAN; PRIORITY JOURNAL; PSYCHOLOGIC TEST; SHORT SURVEY;

ANTINEOPLASTIC AGENTS; CELL DEATH; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; NEOPLASMS; NF-KAPPA B;

EID: 67650787335     PISSN: 15548929     EISSN: None     Source Type: Journal    
DOI: 10.1021/cb900150g     Document Type: Short Survey

References (10)

1. LaCasse, E. C., Mahoney, D. J., Cheung, H. H., Plenchette, S., Baird, S., and Korneluk, R. G. (2008) IAP-targeted therapies for cancer, Oncogene 27, 6252-6275.
2. Ndubaku, C., Varfolomeev, E., Wang, L., Zobel, K., Lau, K., Elliott, L. O., Maurer, B., Fedorova, A. V., Dynek, J. N., Koehler, M., Hymowitz, S. G., Tsui, V., Deshayes, K., Fairbrother, W. J., Flygare, J. A., and Vucic, D. (2009) Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists, ACS Chem. Biol 4, 557-566.
3. Eckelman, B. P., Salvesen, G. S., and Scott, F. L. (2006) Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family, EMBO Rep. 7, 988-994.
4. Eckelman, B. P., and Salvesen, G. S. (2006) The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases, J. Biol. Chem. 281, 3254-3260.
5. Bertrand, M. J., Milutinovic, S., Dickson, K. M., Ho, W. C., Boudreault, A., Durkin, J., Gillard, J. W., Jaquith, J. B., Morris, S. J., and Barker, P. A. (2008) cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination, Mol. Cell 30, 689-700. (Pubitemid 351818251)
6. Varfolomeev, E., Blankenship, J. W., Wayson, S. M., Fedorova, A. V., Kayagaki, N., Garg, P., Zobel, K., Dynek, J. N., Elliott, L. O., Wallweber, H. J., Flygare, J. A., Fairbrother, W. J., Deshayes, K., Dixit, V. M., and Vucic, D. (2007) IAP antagonists induce autoubiquitination of c-IAPs, NF-κB activation, and TNFα-dependent apoptosis, Cell 131, 669-681. (Pubitemid 350087204)
7. Vince, J. E., Wong, W. W., Khan, N., Feltham, R., Chau, D., Ahmed, A. U., Benetatos, C. A., Chunduru, S. K., Condon, S. M., McKinlay, M., Brink, R., Leverkus, M., Tergaonkar, V., Schneider, P., Callus, B. A., Koentgen, F., Vaux, D. L., and Silke, J. (2007) IAP antagonists target cIAP1 to induce TNFα-dependent apoptosis, Cell 131, 682-693. (Pubitemid 350103599)
8. Petersen, S. L., Wang, L., Yalcin-Chin, A., Li, L., Peyton, M., Minna, J., Harran, P., and Wang, X. (2007) Autocrine TNFα signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis, Cancer Cell 12, 445-456. (Pubitemid 350064365)
9. Wang, L., Du, F., and Wang, X. (2008) TNF-α induces two distinct caspase-8 activation pathways, Cell 133, 693-703. (Pubitemid 351636305)
10. Bertrand, M. J., Doiron, K., Labbé, K., Korneluk, R. G., Barker, P. A., and Saleh, M. (2009) Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2, Immunity 30, 789-801.