Homocysteine editing and growth inhibition in Escherichia coli

Microbiology

Volumn 155, Issue 6, 2009, Pages 1858-1865

  Sikora, Marta ^a,b   Jakubowski, Hieronim ^a,b  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b INSTITUTE OF BIOORGANIC CHEMISTRY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ADENOSINE TRIPHOSPHATE; HOMOCYSTEINE; HOMOCYSTEINE THIOLACTONE; ISOLEUCINE; LEUCINE; METHIONINE; AMINO ACID TRANSFER RNA LIGASE; DRUG DERIVATIVE;

AMINO ACID ANALYSIS; AMINO ACID METABOLISM; AMINO ACID SYNTHESIS; ARTICLE; BACTERIAL CELL; BACTERIAL GROWTH; BACTERIUM CULTURE; BIOACCUMULATION; CELL VIABILITY; CONTROLLED STUDY; ENERGY COST; ESCHERICHIA COLI; GROWTH ACCELERATION; GROWTH INHIBITION; GROWTH RATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN SYNTHESIS INHIBITION; RNA EDITING; RNA TRANSLATION; BIOSYNTHESIS; ENERGY METABOLISM; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PROTEIN SYNTHESIS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

ADENOSINE TRIPHOSPHATE; AMINO ACYL-TRNA SYNTHETASES; ENERGY METABOLISM; ESCHERICHIA COLI; HOMOCYSTEINE; ISOLEUCINE; LEUCINE; METHIONINE; PROTEIN BIOSYNTHESIS; SODIUM ACETATE;

EID: 67650762757     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.026609-0     Document Type: Article

References (34)

1. Chwatko, G. & Jakubowski, H. (2005). The determination of homocysteine-thiolactone in human plasma. Anal Biochem 337, 271-277.
2. Chwatko, G., Boers, G. H., Strauss, K. A., Shih, D. M. & Jakubowski, H. (2007). Mutations in methylenetetrahydrofolate reductase or cystathionine beta-synthase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice. FASEB J 21, 1707-1713.
3. Gao, W., Goldman, E. & Jakubowski, H. (1994). Role of carboxy-terminal region in proofreading function of methionyl-tRNA synthetase in Escherichia coli. Biochemistry 33, 11528-11535.
4. Ingraham, J. L., Maaløe, O. & Neidhardt, F. C. (1983). Growth of the Bacterial Cell. Sunderland, MA: Sinauer Associates.
5. Jakubowski, H. (1990). Proofreading in vivo: editing of homocysteine by methionyl-tRNA synthetase in Escherichia coli. Proc Natl Acad Sci U S A 87, 4504-4508.
6. Jakubowski, H. (1991). Proofreading in vivo: editing of homocysteine by methionyl-tRNA synthetase in the yeast Saccharomyces cerevisiae. EMBO J 10, 593-598.
7. Jakubowski, H. (1993). Energy cost of proofreading in vivo: the charging of methionine tRNAs in Escherichia coli. FASEB J 7, 168-172.
8. Jakubowski, H. (1995). Proofreading in vivo. Editing of homocysteine by aminoacyl-tRNA synthetases in Escherichia coli. J Biol Chem 270, 17672-17673.
9. Jakubowski, H. (1997a). Metabolism of homocysteine thiolactone in human cell cultures. Possible mechanism for pathological consequences of elevated homocysteine levels. J Biol Chem 272, 1935-1942.
10. Jakubowski, H. (1997b). Aminoacyl thioester chemistry of class II aminoacyl-tRNA synthetases. Biochemistry 36, 11077-11085.
11. Jakubowski, H. (1999a). Misacylation of tRNALys with noncognate amino acids by lysyl-tRNA synthetase. Biochemistry 38, 8088-8093.
12. Jakubowski, H. (1999b). Protein homocysteinylation: possible mechanism underlying pathological consequences of elevated homocysteine levels. FASEB J 13, 2277-2283.
13. Jakubowski, H. (2000). Translational incorporation of S-nitrosohomocysteine into protein. J Biol Chem 275, 21813-21816.
14. Jakubowski, H. (2001a). Protein N-homocysteinylation: implications for atherosclerosis. Biomed Pharmacother 55, 443-447.
15. Jakubowski, H. (2001b). Translational accuracy of aminoacyl-tRNA synthetases: implications for atherosclerosis. J Nutr 131, 2983S-2987S.
16. Jakubowski, H. (2002a). The determination of homocysteine-thiolactone in biological samples. Anal Biochem 308, 112-119.
17. Jakubowski, H. (2002b). Homocysteine is a protein amino acid in humans. Implications for homocysteine-linked disease. J Biol Chem 277, 30425-30428.
18. Jakubowski, H. (2004). Molecular basis of homocysteine toxicity in humans. Cell Mol Life Sci 61, 470-487.
19. Jakubowski, H. (2005a). tRNA synthetase editing of amino acids. In Encyclopedia of Life Sciences http://mrw.interscience.wiley.com/ emrw/9780470015902/els/article/a0000532/current/abstract doi:10.1038/ npg.els.0003933.
20. Jakubowski, H. (2005b). Accuracy of aminoacyl-tRNA synthetases: proofreading of amino acids. In The Aminoacyl-tRNA Synthetases, pp. 384-396. Edited by M. Ibba, C. Francklyn & S. Cusack. Georgetown, TX: Landes Bioscience/Eurekah.com.
21. Jakubowski, H. (2006a). Pathophysiological consequences of homocysteine excess. J Nutr 136, 1741S-1749S.
22. Jakubowski, H. (2006b). Mechanism of the condensation of homocysteine thiolactone with aldehydes. Chemistry 12, 8039-8043.
23. Jakubowski, H. (2007a). The molecular basis of homocysteine thiolactone-mediated vascular disease. Clin Chem Lab Med 45, 1704-1716.
24. 35S] homocysteine. Anal Biochem 370, 124-126.
25. Jakubowski, H. (2008). New method for the determination of protein N-linked homocysteine. Anal Biochem 380, 257-261.
26. Jakubowski, H. & Fersht, A. R. (1981). Alternative pathways for editing non-cognate amino acids by aminoacyl-tRNA synthetases. Nucleic Acids Res 9, 3105-3117.
27. Jakubowski, H. & Goldman, E. (1992). Editing of errors in selection of amino acids for protein synthesis. Microbiol Rev 56, 412-429.
28. Karkhanis, V. A., Mascarenhas, A. P. & Martinis, S. A. (2007). Amino acid toxicities of Escherichia coli that are prevented by leucyl-tRNA synthetase amino acid editing. J Bacteriol 189, 8765-8768.
29. Kumar, A., John, L., Alam, M. M., Gupta, A., Sharma, G., Pillai, B. & Sengupta, S. (2006). Homocysteine- and cysteine-mediated growth defect is not associated with induction of oxidative stress response genes in yeast. Biochem J 396, 61-69.
30. Mulvey, R. S. & Fersht, A. R. (1977). Editing mechanisms in aminoacylation of tRNA: ATP consumption and the binding of aminoacyl-tRNA by elongation factor Tu. Biochemistry 16, 4731-4737.
31. Roe, A. J., O'Byrne, C., McLaggan, D. & Booth, I. R. (2002). Inhibition of Escherichia coli growth by acetic acid: a problem with methionine biosynthesis and homocysteine toxicity. Microbiology 148, 2215-2222.
32. Teusink, B., van Enckevort, F. H., Francke, C., Wiersma, A., Wegkamp, A., Smid, E. J. & Siezen, R. J. (2005). In silico reconstruction of the metabolic pathways of Lactobacillus plantarum: comparing predictions of nutrient requirements with those from growth experiments. Appl Environ Microbiol 71, 7253-7262.
33. Tuite, N. L., Fraser, K. R. & O'Byrne, C. P. (2005). Homocysteine toxicity in Escherichia coli is caused by a perturbation of branched-chain amino acid biosynthesis. J Bacteriol 187, 4362-4371.
34. Zimny, J., Sikora, M., Guranowski, A. & Jakubowski, H. (2006). Protective mechanisms against homocysteine toxicity: the role of bleomycin hydrolase. J Biol Chem 281, 22485-22492.