Randomized trial comparing locoregional resection of primary tumor with no surgery in stage iv breast cancer at the presentation (Protocol MF07-01): A study of turkish federation of the national societies for breast diseases

Breast Journal

Volumn 15, Issue 4, 2009, Pages 399-403

  Soran, Atilla ^a   Ozbas, Serdar ^b   Kelsey, Sheryl F ^c   Gulluoglu, Bahadir M ^d  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b ADNAN MENDERES UNIVERSITY   (Turkey)

^c UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^d MARMARA UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

Breast cancer; Metastasis; Randomized trial; Surgery; Survival

Indexed keywords

DOCETAXEL; DOXORUBICIN; ESTROGEN RECEPTOR; GONADORELIN DERIVATIVE; PROGESTERONE RECEPTOR; TAMOXIFEN; TRASTUZUMAB;

ADULT; AGED; ARTICLE; BREAST CANCER; BREAST DISEASE; CANCER CHEMOTHERAPY; CANCER HORMONE THERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISTANT METASTASIS; DRUG DOSE SEQUENCE; FEMALE; FOLLOW UP; HUMAN; KAPLAN MEIER METHOD; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MASTECTOMY; MEDICAL SOCIETY; MORBIDITY; MULTICENTER STUDY; MULTIMODALITY CANCER THERAPY; MULTIPLE CYCLE TREATMENT; OVERALL SURVIVAL; PHASE 3 CLINICAL TRIAL; POSTMENOPAUSE; PREMENOPAUSE; PRIMARY TUMOR; PROGRESSION FREE SURVIVAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SHORT FORM 36; TREATMENT OUTCOME; TURKEY (REPUBLIC);

BREAST NEOPLASMS; FEMALE; HUMANS; MASTECTOMY, SEGMENTAL; NEOPLASM STAGING; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; SURVIVAL ANALYSIS; SURVIVORS; TIME FACTORS; TREATMENT OUTCOME; TURKEY;

EID: 67650760407     PISSN: 1075122X     EISSN: 15244741     Source Type: Journal    
DOI: 10.1111/j.1524-4741.2009.00744.x     Document Type: Article

References (14)

1. Carmichael AR, Anderson EDC, Chetty U, Dixon JM. Does local surgery have a role in the management of stage IV breast cancer? Eur J Surg Oncol 2003 29 : 17 9.
2. Gnerlich J, Jeffe DB, Deshpande AD, Beers C, Zander C, Margenthaler JA. Surgical removal of the primary tumor increases overall survival in patients with metastatic breast cancer: analysis of the 1988-2003 SEER data. Ann Surg Oncol 2007 14 : 2187 94.
3. Blanchard DK, Bhatia P, Hilsenbeck SG, Elledge RM. Does surgical management of stage IV breast cancer affect outcome? (abstract 2110). Breast Cancer Res Treat 2006 100 (suppl 1 S118.
4. Hortobagyi GN. Treatment of breast cancer. N Eng J Med 1998 339 : 974 84.
5. Khan SA, Stewart AK, Morrow M. Does aggressive local therapy improve survival in metastatic breast cancer? Surgery 2002 132 : 620 7.
6. Babiera GV, Rao R, Feng L, et al. Effect of primary tumor extirpation in breast cancer patients who present with stage IV disease and an intact primary tumor. Ann Surg Oncol 2006 13 : 776 82.
7. Rapiti E, Verkooijen HM, Vlastos G, et al. Complete excision of primary breast tumor improves survival of patients with metastatic breast cancer at diagnosis. J Clin Oncol 2006 24 : 2743 9.
8. Fields RC, Jeffe DB, Trinkaus K, et al. Surgical resection of the primary tumor is associated with increased long-term survival in patients with stage IV breast cancer after controlling for site of metastasis. Ann Surg Oncol 2007 14 : 3345 51.
9. Blumenschein GR, Distefano A, Caderao J, et al. Multimodality therapy for locally advanced and limited stage IV breast cancer: the impact of effective non-cross-resistance late-consolidation chemotherapy. Clin Cancer Res 1997 3 : 2633 7.
10. Nieto Y, Cagnoni PJ, Shpall EJ, et al. Phase II trial of high-dose chemotherapy with autologous stem cell transplant for stage IV breast cancer with minimal metastatic disease. Clin Cancer Res 1991 5 : 1731 7.
11. Juan O, Lluch A, de Paz L, et al. Prognostic factors in patients with isolated recurrences of breast cancer (stage IV-NED). Breast Cancer Res Treat 1999 53 : 105 12.
12. Khan SA. Primary tumor resection in stage IV breast cancer: consistent benefit, or consistent bias? Ann Surg Oncol 2007 14 : 3285 7.
13. Danna EA, Sinha P, Gilbert M, Clements UK, Pulaski BA, Ostrand-Rosenberg S. Surgical removal of primary tumor reverses tumor-induced immunosuppression despite the presence of metastatic disease. Cancer Res 2004 64 : 2205 11.
14. Demicheli R, Retsky MW, Swartzendruber DE, Bonadonna G. Proposal for a new model of breast cancer metastatic development. Ann Oncol 1997 8 : 1075 80.