Combined pathological effects of cocaine abuse and HIV infection on the cardiovascular system: An autopsy study of 187 cases from the Fulton county medical examiner's office

American Journal of Forensic Medicine and Pathology

Volumn 29, Issue 1, 2008, Pages 9-13

  Mosunjac, Mario I ^a   Sundstrom, J Bruce ^a   Heninger, Michael ^b   Ansari, Aftab A ^a   Mosunjac, Marina B ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Fulton County Medical Examiner's Office   (United States)

Author keywords

Cardiovascular pathology; Cocaine; Coronary infiltrates; HIV AIDS; Myocardial hypertrophy; Myocardial infiltrates

Indexed keywords

ADULT; ARTICLE; AUTOPSY; CARDIOVASCULAR SYSTEM; COCAINE DEPENDENCE; CONTROL GROUP; CONTROLLED STUDY; FEMALE; HEART INFARCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE FIBROSIS; HEART WEIGHT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MORPHOLOGY; MYOCARDITIS;

ADULT; CASE-CONTROL STUDIES; COCAINE-RELATED DISORDERS; CORONARY ARTERY DISEASE; CORONARY VESSELS; CORONERS AND MEDICAL EXAMINERS; EOSINOPHILS; FEMALE; FIBROSIS; FORENSIC PATHOLOGY; GEORGIA; HIV INFECTIONS; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; LYMPHOCYTES; MALE; MYOCARDIAL INFARCTION; MYOCARDITIS; MYOCARDIUM; ORGAN SIZE; RETROSPECTIVE STUDIES;

EID: 67650750904     PISSN: 01957910     EISSN: None     Source Type: Journal    
DOI: 10.1097/PAF.0b013e318165152f     Document Type: Article

References (36)

1. Winslow RD, Mehta D, Fuster V. Sudden cardiac death: mechanisms, therapies and challenges. Natl Clin Pract Cardiovasc Med. 2005;2: 352-360.
2. Cregler LL. Cocaine: the newest risk factor for cardiovascular disease. Clin Cardiol. 1991;14:449-456.
3. Karch SB, Green GS, Young S. Myocardial hypertrophy and coronary artery disease in male cocaine users. J Forensic Sci. 1995;40:591-595.
4. Williams RG, Kavanagh KM, Teo KK. Pathophysiology and treatment of cocaine toxicity: implications for the heart and cardiovacsular system. Can J Cardiol. 1996;12:1295-1301.
5. Karch SB, Stephens BS. When is cocaine the cause of death? Am J Forensic Med Pathol. 1991;12:1-2.
6. Tazelaar HD, Karch SB, Stephens BS, et al. Cocaine and the Heart. Hum Pathol. 1987;18:195-199.
7. Dressler FA, Malekzadeh S, Roberts WC. Quantitative analysis of amounts of coronary arterial narrowing in cocaine addicts. Am J Cardiol. 1990;65:303-308.
8. Kloner RA, Hale S, Alker K, et al. The effects of acute and chronic cocaine use on the heart. Circulation. 1992;85:407-419.
9. Milei J, Grana D, Alonso GF, et al. Cardiac involvement in acquired immunodeficiency syndrome-a review to push action. Clin Cardiol. 1998;21:465-472.
10. Williams L, Grody WW. AIDS and the heart: review and consideration of pathogenic mechanisms. Cardiovasc Pathol. 1992;1:53-64.
11. De Castro S, Migliau G, Silvestri A, et al. Heart involvement in AIDS: a prospective study during various stages of the disease. Eur Heart J. 1992;13:1452-1459.
12. Tabib A, Leroux C, Mornex JF, et al. Accelerated coronary atherosclerosis and arteriosclerosis in young human-immunodeficiency-virus-positive-patients. Coronary Artery Dis. 2000;11:41-46.
13. Paton P, Tabib A, Loire R, et al. Coronary artery lesions and human immunodeficiency virus infection. Res Virol. 1993;144:225-231.
14. Barbaro G, DiLorenzo G, Grisorio B, et al. Cardiac involvement in the acquired immunodeficiency syndrome: a multicenter clinical-pathological study. AIDS Res Hum Retroviruses. 1998;14:1071-1077.
15. Domanski MJ, Sloas MM, Follmann DA, et al. Effect of zidovudine and didanosine treatment on heart function in children infected with human immunodeficiency virus. J Pediatr. 1995;127:137-146.
16. Sundstrom JB, Ansari AA. Pathogenesis of AIDS-related dilated cardiomyopathy. AIDS Rev. 2001;3:36-43.
17. Sundstrom JB, Martinson DE, Mosunjac M, et al. Norepinephrine enhances adhesion of HIV-1-infected leukocytes to cardiac microvascular endothelial cells. Exp Biol Med (Maywood). 2003;228:730-740.
18. Kim J, Ruff M, Karwatowska-Prokopczuk E, et al. HIV envelope protein gp120 neuropetide y receptor-mediated proliferation of vascular smooth muscle cells: relevance to AIDS cardiovacsular pathogenesis. Regul Pept. 1998;75/76:201-205.
19. Fiala M, Popik W, Qiao JH, et al. HIV-induces cardiomyopathy by cardiomyocyte invasion and gp120, Tat, and cytokine apoptotic signaling. Cardiovasc Toxicol. 2004;4:97-107.
20. Huang MB, Khan M, Garcia-Barrio M, et al. Apoptotic effects in primary human umbilical vein endothelial cell cultures caused by exposure to virion-associated and cell membrane-associated HIV-1 gp 120. J Acquir Immune Defic Syndr. 2001;1:27:213-221.
21. Periard D, Telenti A, Sudre P, et al. Atherogenic dyslipidemia in HIV-infected individuals treated with protease inhibitors. Circulation. 1999;100:700-705.
22. Klinkenberg WD, Sacks S. Mental disorders and drug abuse in persons living with HIV/AIDS. AIDS Care. 2004;16(Suppl 1):S22-S42.
23. Aretz HT, Billingham ME, Edwards WD, et al. Myocarditis a histopathologic definition and classification. Am J Cardiovasc Pathol. 1986;1:1-14.
24. Willett DWL, Brickner ME, Cigarroa CG, et al. Racial differences in the prevalence of left ventricular hypertrophy among chronic cocaine abusers. Am J Cardiol. 1995;76:937-940.
25. Brickner ME, Willard JE, Eichhorn EJ, et al. Increased left ventricular mass and wall thickness associated with chronic cocaine abuse. Circulation. 1991;84:1130-1135.
26. Chakko S, Fernandez A, Melman TA, et al. Cardiac manifestation of cocaine abuse: a cross-sectional study of asymptomatic men with a history of long-term abuse of "crack" cocaine. Am J Coll Cardiol. 1992;20:1168-1174.
27. Atkinson JB, Harlan CW, Harlan GC, et al. The association of mast cells and atherosclerosis: a morphological study of early atherosclerotic lesions in young people. Hum Pathol. 1994;25:154-159.
28. Pattela V, Marino I, Arbustini E, et al. Stem cell factor in mast cells and increased mast cell density in idiopathic and ischemic cardiomyopathy. Circulation. 1998;97:971-978.
29. Laine P, Naukkarinen A, Heikkila L, et al. Adventitial mast cells with sensory nerve fibers in atherosclerotic coronary arteries. Circulation. 2000;101:1665-1669.
30. Kolodgie FD, Virmani R, Cornhill JF, et al. Increase in atherosclerosis and adventitial mast cells in cocaine abusers: an alternative mechanism of cocaine-associated coronary vasospasm and thrombosis. J Am Coll Cardiol. 1991;17:1553-1560.
31. Reilly JM, Cunnion RE, Anderson DW, et al. Frequency of myocarditism left ventricular dysfunction and ventricular tachicardia in the acquired immune deficiency syndrome. Am J Cardiol. 1988;62:789-793.
32. Baroldi G, Corallo S, Moroni M, et al. Focal lymphocitic myocxarditis in acquired immunodeficiency syndrome (AIDS): a correlative morphologic and clinical study in 26 consecutive fatal cases. J Am Coll Cardiol. 1988;12:463-469.
33. Anderson D, Virmani R, Reilly J, et al. Prevalent myocarditis at necropsy in the acquired immunodeficiency syndrome. J Am Coll Cardiol. 1988;11:792-799.
34. Lewis W, Grody W. AIDS and the heart: review and consideration of pathogenetic mechanisms. Cardiovasc Pathol. 1922;1:53-64.
35. Lai S, Lima JA, Lai H, et al. Human immunodeficiency virus 1 infection, cocaine, and coronary calcification. Arch Intern Med. 52005;165:690-695.
36. Sunstrom JB, Mosunjac M, Martinson DE, et al. Effects of norepinephrine, HIV type 1 infection, and leukocyte interactions with endothelial cells on the expression of matrix metalloproteinases. AIDS Res Hum Retroviruses. 2001;20:17:1605-1614.