Body surface projection of action potential duration alternans: A combined clinical-modeling study with implications for improving T-wave alternans detection

Heart Rhythm

Volumn 6, Issue 8, 2009, Pages 1211-1219

  Selvaraj, Raja J ^a   Suszko, Adrian M ^a   Subramanian, Anandaraja ^a   Sivananthan, Dhinesh ^a   Hill, Ann ^a   Nanthakumar, Kumaraswamy ^a   Chauhan, Vijay S ^a  

^a UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Action potential duration alternans; Body surface mapping; Cardiomyopathy; Forward solution; T wave alternans

Indexed keywords

ACTION POTENTIAL; ADULT; AGED; ARTICLE; BODY SURFACE; CARDIOMYOPATHY; CLINICAL ARTICLE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE POTENTIAL; HUMAN; PRIORITY JOURNAL; T WAVE;

ACTION POTENTIALS; BODY SURFACE POTENTIAL MAPPING; CARDIOMYOPATHIES; ELECTROCARDIOGRAPHY; ENDOCARDIUM; HEART CONDUCTION SYSTEM; HUMANS; MODELS, BIOLOGICAL; PERICARDIUM; STATISTICS AS TOPIC; STROKE VOLUME; TIME FACTORS; VENTRICULAR FUNCTION, LEFT;

EID: 67650735138     PISSN: 15475271     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hrthm.2009.04.002     Document Type: Article

References (23)

1. Chow T., Kereiakes D.J., Bartone C., et al. Prognostic utility of microvolt T-wave alternans in risk stratification of patients with ischemic cardiomyopathy. J Am Coll Cardiol 47 (2006) 1820-1827
2. Bloomfield D.M., Bigger J.T., Steinman R.C., et al. Microvolt T-wave alternans and the risk of death or sustained ventricular arrhythmias in patients with left ventricular dysfunction. J Am Coll Cardiol 47 (2006) 456-463
3. Pastore J.M., Girouard S.D., Laurita K.R., et al. Mechanism linking T-wave alternans to the genesis of cardiac fibrillation. Circulation 99 (1999) 1385-1394
4. Selvaraj R.J., Picton P., Nanthakumar K., et al. Endocardial and epicardial repolarization alternans in human cardiomyopathy: evidence for spatiotemporal heterogeneity and correlation with body surface T-wave alternans. J Am Coll Cardiol 49 (2007) 338-346
5. Shimizu W., Yamada K., Arakaki Y., et al. Monophasic action potential recordings during T-wave alternans in congenital long QT syndrome. Am Heart J 132 (1996) 699-701
6. Haghjoo M., Arya A., and Sadr-Ameli M.A. Microvolt T-wave alternans: a review of techniques, interpretation, utility, clinical studies, and future perspectives. Int J Cardiol 109 (2006) 293-306
7. Verrier R.L., Nearing B.D., and Kwaku K.F. Noninvasive sudden death risk stratification by ambulatory ECG-based T-wave alternans analysis: evidence and methodological guidelines. Ann Noninvasive Electrocardiol 10 (2005) 110-120
8. van Oosterom A., and Oostendorp T.F. ECGSIM: an interactive tool for studying the genesis of QRST waveforms. Heart 90 (2004) 165-168
9. Narayan S.M., Bayer J.D., Lalani G., and Trayanova N.A. Action potential dynamics explain arrhythmic vulnerability in human heart failure: a clinical and modeling study implicating abnormal calcium handling. J Am Coll Cardiol 52 (2008) 1782-1792
10. Frank E. An accurate, clinically practical system for spatial vectorcardiography. Circulation 13 (1956) 737-749
11. Shimizu W., and Antzelevitch C. Cellular and ionic basis for T-wave alternans under long-QT conditions. Circulation 99 (1999) 1499-1507
12. Nearing B.D., Oesterle S.N., and Verrier R.L. Quantification of ischaemia induced vulnerability by precordial T wave alternans analysis in dog and human. Cardiovasc Res 28 (1994) 1440-1449
13. Martinez J.P., Olmos S., Wagner G., et al. Characterization of repolarization alternans during ischemia: time-course and spatial analysis. IEEE Trans Biomed Eng 53 (2006) 701-711
14. Narayan S.M., Smith J.M., Lindsay B.D., et al. Relation of T-wave alternans to regional left ventricular dysfunction and eccentric hypertrophy secondary to coronary heart disease. Am J Cardiol 97 (2006) 775-780
15. Klingenheben T., Ptaszynski P., and Hohnloser S.H. Quantitative assessment of microvolt T-wave alternans in patients with congestive heart failure. J Cardiovasc Electrophysiol 6 (2005) 620-624
16. Yan G.X., and Antzelevitch C. Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome. Circulation 98 (1998) 1928-1936
17. Janse M.J., Sosunov E.A., Coronel R., et al. Repolarization gradients in the canine left ventricle before and after induction of short-term cardiac memory. Circulation 112 (2005) 1711-1718
18. Nearing B.D., and Verrier R.L. Tracking cardiac electrical instability by computing interlead heterogeneity of T-wave morphology. J Appl Physiol 95 (2003) 2265-2272
19. Verrier R.L., Kwaku K.F., Nearing B.D., et al. T-wave alternans: does size matter. J Cardiovasc Electrophysiol 16 (2005) 625-628
20. Madias J.E. Reproducibility of the T-wave alternans and dependence of T-wave alternans on the T-wave amplitude: 2 issues requiring immediate attention. J Electrocardiol 40 (2007) 364.e1-364.e3
21. Huiskamp G., and Van Oosterom A. The depolarization sequence of the human heart surface computed from measured body surface potentials. IEEE Trans Biomed Eng 35 (1988) 1047-1058
22. van Oosterom A. Genesis of the T wave as based on an equivalent surface source model. J Electrocardiol 34 Suppl (2001) 217-227
23. Saitoh H., Bailey J.C., and Surawicz B. Alternans of action potential duration after abrupt shortening of cycle length: differences between dog Purkinje and ventricular muscle fibers. Circ Res 62 (1988) 1027-1040