N-Acetyl-S-(1-carbamoyl-2-hydroxy-ethyl)-l-cysteine (iso-GAMA) a further product of human metabolism of acrylamide: Comparison with the simultaneously excreted other mercaptuic acids

Archives of Toxicology

Volumn 83, Issue 7, 2009, Pages 731-734

  Hartmann, Eva C ^a   Boettcher, Melanie I ^a   Bolt, Hermann M ^b   Drexler, Hans ^a   Angerer, Jürgen ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

Author keywords

Acrylamide; Glycidamide; Metabolism; Toxicokinetics

Indexed keywords

ACRYLAMIDE; ACRYLAMIDE DERIVATIVE; CARCINOGEN; DEUTERIUM; GLYCIDAMIDE; N ACETYL S (1 CARBAMOYL 2 HYDROXYETHYL)CYSTEINE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; DETOXIFICATION; DIETARY INTAKE; ELECTROSPRAY MASS SPECTROMETRY; FOOD; GENOTOXICITY; HEATING; HUMAN; HUMAN EXPERIMENT; INGESTION; ISOTOPE LABELING; KINETICS; LIQUID CHROMATOGRAPHY; MALE; METABOLITE; NORMAL HUMAN; PRIORITY JOURNAL; TOXICOKINETICS; URINARY EXCRETION;

ACETYLCYSTEINE; ACRYLAMIDE; CARCINOGENS; CYSTEINE; EPOXY COMPOUNDS; HUMANS; KINETICS; MALE; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; SENSITIVITY AND SPECIFICITY;

EID: 67650732952     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-008-0369-8     Document Type: Article

References (13)

1. MI Boettcher J Angerer 2005 Determination of the major mercapturic acids of acrylamide and glycidamide in human urine by LC-ESI-MS/MS J Chromatogr B Analyt Technol Biomed Life Sci 824 283 294 (Pubitemid 41215609)
2. MI Boettcher T Schettgen B Kutting M Pischetsrieder J Angerer 2005 Mercapturic acids of acrylamide and glycidamide as biomarkers of the internal exposure to acrylamide in the general population Mutat Res 580 167 176
3. MI Boettcher HM Bolt J Angerer 2006 Acrylamide exposure via the diet: influence of fasting on urinary mercapturic acid metabolite excretion in humans Arch Toxicol 80 817 819 (Pubitemid 44833078)
4. MI Boettcher HM Bolt H Drexler J Angerer 2006 Excretion of mercapturic acids of acrylamide and glycidamide in human urine after single oral administration of deuterium-labelled acrylamide Arch Toxicol 80 55 61 (Pubitemid 43130229)
5. DFG (Deutsche Forschungsgemeinschaft) (2002) Maximale Arbeitsplatzkonzentrationen und biologische Arbeitsstoff Toleranzwerte. Mitteilung XXXVIII der Senatskommission zur Prüfung gesundheitsschä dlicher Arbeitsstoffe. Wiley-VCH, Weinheim
6. EPA US (Office of Toxic Substances; U.S. Environmental Protection Agency) (1994) Chemical summary for acrylamide, Washington DC
7. EU European Commission (2001) Opinion on the results of the risk assessment of: acrylamide. Scientific Committee on Food, Brussels
8. TR Fennell 2005 Metabolism and hemoglobin adduct formation of acrylamide in humans Toxicol Sci 85 447 459 (Pubitemid 40614275)
9. U Fuhr 2006 Toxicokinetics of acrylamide in humans after ingestion of a defined dose in a test meal to improve risk assessment for acrylamide carcinogenicity Cancer Epidemiol Biomarkers Prev 15 266 271 (Pubitemid 43342173)
10. EC Hartmann MI Boettcher T Schettgen H Fromme H Drexler J Angerer 2008 Hemoglobin adducts and mercapturic acid excretion of acrylamide and glycidamide in one study population J Agric Food Chem 56 6061 6068
11. IARC (International Agency for Research on Cancer) (1994) Acrylamide. Summaries and evaluations, vol 60, p 389
12. SC Sumner JP MacNeela TR Fennell 1992 Characterization and quantitation of urinary metabolites of [1, 2, 3-13C]acrylamide in rats and mice using 13C nuclear magnetic resonance spectroscopy Chem Res Toxicol 5 81 89
13. E Tareke P Rydberg P Karlsson S Eriksson M Tornqvist 2002 Analysis of acrylamide, a carcinogen formed in heated foodstuffs J Agric Food Chem 50 4998 5006 (Pubitemid 34856181)