Abnormal transmural repolarization process in patients with Brugada syndrome

Heart Rhythm

Volumn 6, Issue 8, 2009, Pages 1163-1169

  Sangawa, Mutsuko ^a,b   Morita, Hiroshi ^a   Nakatsu, Takaaki ^b   Nishii, Nobuhiro ^a   Miura, Daiji ^a   Miura, Aya ^a   Tada, Takeshi ^a   Murakami, Masato ^a   Hiramatsu, Shigeki ^a   Nagase, Satoshi ^a   Nakamura, Kazufumi ^a   Oka, Takefumi ^a   Toyonaga, Shinji ^b   Mashima, Keiichi ^b   Kusachi, Shozo ^a   Yamamoto, Kazuhide ^a   Ohe, Tohru ^a   Kusano, Kengo F ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b Kagawa Central Hospital   (Japan)

Author keywords

Brugada syndrome; QT interval; SCN5A; Ventricular fibrillation

Indexed keywords

ADULT; AGED; ARTICLE; BRUGADA SYNDROME; CLINICAL ARTICLE; CONTROLLED STUDY; GENE; GENE MUTATION; GENETIC ANALYSIS; HEART REPOLARIZATION; HEART VENTRICLE FIBRILLATION; HOLTER MONITORING; HUMAN; MALE; PRIORITY JOURNAL; QT INTERVAL; RR INTERVAL; SCN5A GENE;

ADULT; AGED; ANALYSIS OF VARIANCE; BRUGADA SYNDROME; CASE-CONTROL STUDIES; ELECTROCARDIOGRAPHY, AMBULATORY; HUMANS; MALE; MIDDLE AGED; MUSCLE PROTEINS; SODIUM CHANNELS; STATISTICS AS TOPIC; VENTRICULAR FIBRILLATION;

EID: 67650732301     PISSN: 15475271     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hrthm.2009.04.037     Document Type: Article

References (24)

1. Brugada J., Brugada R., and Brugada P. Right bundle-branch block and ST-segment elevation in leads V1 through V3: a marker for sudden death in patients without demonstrable structural heart disease. Circulation 97 (1998) 457-460
2. Antzelevitch C., Yan G.X., and Shimizu W. Transmural dispersion of repolarization and arrhythmogenicity: the Brugada syndrome versus the long QT syndrome. J Electrocardiol 32 (1999) 158-165
3. Fujiki A., Sugao M., Nishida K., et al. Repolarization abnormality in idiopathic ventricular fibrillation: assessment using 24-hour QT-RR and QaT-RR relationships. J Cardiovasc Electrophysiol 15 (2004) 59-63
4. Sugao M., Fujiki A., Nishida K., et al. Repolarization dynamics in patients with idiopathic ventricular fibrillation: pharmacological therapy with bepridil and disopyramide. J Cardiovasc Pharmacol 45 (2005) 545-549
5. Schulze-Bahr E., Eckardt L., Breithardt G., et al. Sodium channel gene (SCN5A) mutations in 44 index patients with Brugada syndrome: different incidences in familial and sporadic disease. Hum Mutat 21 (2003) 651-652
6. Antzelevitch C., Brugada P., Borggrefe M., et al. Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation 111 (2005) 659-670
7. Brugada R., Brugada J., Antzelevitch C., et al. Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts. Circulation 101 (2000) 510-515
8. Tada T., Kusano K.F., Nagase S., et al. Clinical significance of macroscopic T-wave alternans after sodium channel blocker administration in patients with Brugada syndrome. J Cardiovasc Electrophysiol 19 (2008) 56-61
9. Matsuo K., Kurita T., Inagaki M., et al. The circadian pattern of the development of ventricular fibrillation in patients with Brugada syndrome. Eur Heart J 20 (1999) 465-470
10. Antzelevitch C. Role of spatial dispersion of repolarization in inherited and acquired sudden cardiac death syndromes. Am J Physiol 293 (2007) 2024-2038
11. Antzelevitch C. Brugada syndrome. Pacing Clin Electrophysiol 29 (2006) 1130-1159
12. Morita H., Zipes D.P., Fukushima-Kusano K., et al. Repolarization heterogeneity in the right ventricular outflow tract: correlation with ventricular arrhythmias in Brugada patients and in an in vitro canine Brugada model. Heart Rhythm 5 (2008) 725-733
13. Yan G.X., and Antzelevitch C. Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation. Circulation 100 (1999) 1660-1666
14. Nagase S., Kusano K.F., Morita H., et al. Longer repolarization in the epicardium at the right ventricular outflow tract causes type 1 electrocardiogram in patients with Brugada syndrome. J Am Coll Cardiol 51 (2008) 1154-1161
15. Castro Hevia J., Antzelevitch C., Tornes Barzaga F., et al. Tpeak-Tend and Tpeak-Tend dispersion as risk factors for ventricular tachycardia/ventricular fibrillation in patients with the Brugada syndrome. J Am Coll Cardiol 47 (2006) 1828-1834
16. Opthof T., Coronel R., Wilms-Schopman F.J., et al. Dispersion of repolarization in canine ventricle and the electrocardiographic T wave: Tp-e interval does not reflect transmural dispersion. Heart Rhythm 4 (2007) 341-348
17. Aiba T., Shimizu W., Hidaka I., et al. Cellular basis for trigger and maintenance of ventricular fibrillation in the Brugada syndrome model: high-resolution optical mapping study. J Am Coll Cardiol 47 (2006) 2074-2085
18. Hayashi M., Takatsuki S., Maison-Blanche P., et al. Ventricular repolarization restitution properties in patients exhibiting type 1 Brugada electrocardiogram with and without inducible ventricular fibrillation. J Am Coll Cardiol 51 (2008) 1162-1168
19. Narayan S.M., Franz M.R., Lalani G., Kim J., and Sastry A. T-wave alternans, restitution of human action potential duration, and outcome. J Am Coll Cardiol 50 (2007) 2385-2392
20. Smits J.P., Eckardt L., Probst V., et al. Genotype-phenotype relationship in Brugada syndrome: electrocardiographic features differentiate SCN5A-related patients from non-SCN5A-related patients. J Am Coll Cardiol 40 (2002) 350-356
21. Morita H., Kusano K.F., Miura D., et al. Fragmented QRS as a marker of conduction abnormality and a predictor of prognosis of Brugada syndrome. Circulation 118 (2008) 1697-1704
22. Watanabe H., Koopmann T.T., Le Scouarnec S., et al. Sodium channel beta1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans. J Clin Invest 118 (2008) 2260-2268
23. Yokokawa M., Takaki H., Noda T., et al. Spatial distribution of repolarization and depolarization abnormalities evaluated by body surface potential mapping in patients with Brugada syndrome. Pacing Clin Electrophysiol 29 (2006) 1112-1121
24. Morita H., Nagase S., Miura D., et al. Differential effects of cardiac sodium channel mutations on initiation of ventricular arrhythmias in patients with Brugada syndrome. Heart Rhythm 6 (2009) 487-492