A new method to account for missing data in case-parent triad studies

Human Heredity

Volumn 68, Issue 4, 2009, Pages 268-277

  Bergemann, T L ^a   Huang, Z ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b ABBOTT LABORATORIES   (United States)

Author keywords

Case parent triad design; Log linear models; Missing data

Indexed keywords

ARTICLE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; POISSON DISTRIBUTION; PROGENY; RISK FACTOR;

COMPUTER SIMULATION; CONFIDENCE INTERVALS; CYTOCHROME P-450 CYP1A1; GENETIC PREDISPOSITION TO DISEASE; GENETIC TECHNIQUES; HUMANS; PARENTS; POLYMORPHISM, SINGLE NUCLEOTIDE;

AVES;

EID: 67650700741     PISSN: 00015652     EISSN: 14230062     Source Type: Journal    
DOI: 10.1159/000228924     Document Type: Article

References (22)

1. Ahsan H, Hodge SE, Heiman GA, Begg MD, Susser ES: Relative risk for genetic associations: the case-parent triad as a variant of case-cohort design. Int J Epidemiol 2002;31:669-678. (Pubitemid 34732783)
2. Laird NM, Lange C: Family-based methods for linkage and association analysis. Adv Genet 2008;60:219-252.
3. Steele JR, Wellemeyer AS, Hansen MJ, Reaman GH, Ross JA: Childhood cancer research network: a North American pediatric cancer registry. Cancer Epidemiol Biomarkers Prevention 2006;15:1241-1242. (Pubitemid 44125275)
4. Spielman RS, McGinnis RE, Ewens WJ: Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993;52:506-516. (Pubitemid 23311321)
5. Horvath S, Xu X, Laird NM: The family based association test method: strategies for studying general genotype-phenotype associations. Eur J Hum Genet 2001;9:301-306. (Pubitemid 32366699)
6. Cordell HJ, Barratt BJ, Clayton DG: Case/ pseudocontrol analysis in genetic association studies: A unified framework for detection of genotype and haplotype associations, gene-gene and gene-environment interactions, and parent-of-origin effects. Genet Epidemiol 2004;26:167-185.
7. Weinberg CR, Wilcox AJ, Lie RT: A log-linear approach to case-parent-triad data: assessing effects of disease genes that act either directly or through maternal effects and that may be subject to parental imprinting. Am J Hum Genet 1998;62:969-978.
8. Weinberg CR: Allowing for missing parents in genetic studies of case-parent triads. Am J Hum Genet 1998;64:1186-1193.
9. Umbach DM, Weinberg CR: The use of caseparent triads to study joint effects of genotype and exposure. Am J Hum Genet 2000;66:251-261.
10. Lambert D: Zero-inflated Poisson regression, with an application to defects in manufacturing. Technometrics 1992;34:1-14.
11. Chang PN: Psychosocial needs of long-term childhood cancer survivors: a review of literature. Pediatrician 1991;18:20-24. (Pubitemid 20335008)
12. Guo CY, Cupples LA, Yang Q: Testing informative missingness in genetic studies using case-parent triads. Eur J Hum Genet 2008;16:992-1001.
13. Croiseau P, Genin E, Cordell HJ: Dealing with missing data in family-based association studies: A multiple imputation approach. Hum Hered 2007;63:229-238. (Pubitemid 46457592)
14. Dudbridge F: Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. Hum Hered 2008;66:87-98.
15. McLachlan GJ, Krishnan T: The EM Algorithm and Extensions, ed 2. New York, John Wiley & Sons, 2008.
16. Baker SG: The multinomial - Poisson transformation. Statistician 1994;43:495-504.
17. Broyden CG: The convergence of a class of double-rank minimization algorithms. J Institute Mathematics Applications 1070;6:76-90.
18. Fletcher R: A new approach to variable metric algorithms. Computer J 1970;13:317-322.
19. Shi M, Christensen K, Weinberg CR, Romitti P, Bathum L, Lozada A, Morris RW, Lovett M, Murray JC: Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants. Am J Hum Genet 2007;80:76-90. (Pubitemid 46047652)
20. Allen AS, Satten GA: Statistical models for haplotype sharing in case-parent trio data. Hum Hered 2007;64:35-44.
21. Gjessing HK, Lie RT: Case-parent triads: estimating single- and double-dose effects of fetal and maternal disease gene haplotypes. Ann Hum Genet 2006;79:382-396.
22. Guo CY, Lunetta KL, Destefano AL, Cupples LA: Combined haplotype relative risk (CHRR): a general and simple genetic association test that combines trios and unrelated case-controls. Genet Epidemiol 2008;33:54-62.