Expression of pis (plasmin sensitive) in Staphylococcus aureus negative for pis reduces adherence and cellular invasion and acts by steric hindrance

Journal of Infectious Diseases

Volumn 200, Issue 1, 2009, Pages 107-117

  Hussain, Muzaffar ^a   Schäfer, Daniel ^b   Juuti, Katri M ^c   Peters, Georg ^a   Haslinger Löffler, Bettina ^a   Kuusela, Pentti I ^c,d   Sinha, Bhanu ^b  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; FIBRONECTIN; PLASMIN; PLS PROTEIN; UNCLASSIFIED DRUG; PRIMER DNA;

ARTICLE; BACTERIAL CELL WALL; BACTERIAL STRAIN; BACTERIUM ADHERENCE; CELL INVASION; CELL LINE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; STAPHYLOCOCCUS AUREUS; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; BACTERIAL CHROMOSOME; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; MICROBIOLOGY; PATHOGENICITY; PHYSIOLOGY; POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIUM;

BACTERIAL ADHESION; CHROMOSOMES, BACTERIAL; DNA PRIMERS; ENDOTHELIUM, VASCULAR; FIBRONECTINS; GENE EXPRESSION; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; PLASMIN; POLYMERASE CHAIN REACTION; STAPHYLOCOCCUS AUREUS;

EID: 67650652248     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/599359     Document Type: Article

References (42)

1. Sjodahl J. Repetitive sequences in protein A from Staphyloccus aureus: three highly homologous Fc-binding regions. FEBS Lett 1976; 67:62-7.
2. Forsgren A, Sjoquist J. "Protein A" from S. aureus. I. Pseudo-immune reaction with human gamma-globulin. J Immunol 1966; 97:822-7.
3. Hartleib J, Köhler N, Dickinson RB, et al. Protein A is the von Willebrand factor binding protein on Staphylococcus aureus. Blood 2000; 96:2149-56.
4. Flock JI, Froman G, Jönsson K, et al. Cloning and expression of the gene for a fibronectin-binding protein from Staphylococcus aureus. EMBO J 1987;6:2351-7.
5. Greene C, McDevitt D, Francois P, Vaudaux PE, Lew DP, Foster TJ. Adhesion properties of mutants of Staphylococcus aureus defective in fibronectin-binding proteins and studies on the expression of fnb genes. Mol Microbiol 1995; 17:1143-52.
6. Signäs C, Raucci G, Jönsson K, et al. Nucleotide sequence of the gene for a fibronectin-binding protein from Staphylococcus aureus: use of this peptide sequence in the synthesis of biologically active peptides. Proc Natl Acad Sci U S A 1989;86:699-703.
7. Jönsson K, Signas C, Müller HP, Lindberg M. Two different genes encode fibronectin binding proteins in Staphylococcus aureus. Eur J Biochem 1991;202:1041-8.
8. McDevitt D, Francois P, Vaudaux PE, Foster TJ. Molecular characterization of the clumping factor (fibrinogen receptor) of Staphylococcus aureus. Mol Microbiol 1994; 11:237-48.
9. Ni Eidhin D, Perkins S, Francois P, Vaudaux P, Höök M, Foster TJ. Clumping factor B (CIfB), a new surface-located fibrinogen-binding adhesin of Staphylococcus aureus. Mol Microbiol 1998; 30:245-57.
10. Boden MK, Flock JI. Cloning and characterization of a gene for a 19 kDa fibrinogen-binding protein from Staphylococcus aureus. Mol Microbiol 1994; 12:599-606.
11. Switalski LM, Speziale P, Höök M. Isolation and characterization of a putative collagen receptor from Staphylococcus aureus strain Cowan I. J Biol Chem 1989;264:21080-6.
12. Park PW, Roberts DD, Grosso LE, et al. Binding of elastin to Staphylococcus aureus. J Biol Chem 1991; 266:23399-406.
13. Tung H, Guss B, Hellman U, Persson L, Rubin K, Ryden C. A bone sialoprotein-binding protein from Staphylococcus aureus: a member of the staphylococcal Sdr family. Biochem J 2000;345:611-9.
14. Kuusela P, Saksela O. Binding and activation of plasminogen at the surface of Staphylococcus aureus: increase in affinity after conversion to the Lys form of the ligand. Eur J Biochem 1990; 193:759-65.
15. Hilden P, Savolainen K, Tyynela J, Vuento M, Kuusela P. Purification and characterisation of a plasmin-sensitive surface protein of Staphylococcus aureus. Eur J Biochem 1996; 236:904-10.
16. Ito T, Katayama Y, Asada K, et al. Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 2001;45:1323-36.
17. Savolainen K, Paulin L, Westerlund-Wikstrom B, Foster TJ, Korhonen TK, Kuusela P. Expression of pis, a gene closely associated with the meek gene of methicillin-resistant Staphylococcus aureus, prevents bacterial adhesion in vitro. Infect Immun 2001;69:3013-20.
18. Werbick C, Becker K, Mellmann A, et al. Staphylococcal chromosomal cassette mec type I, spa type, and expression of Pls are determinants of reduced cellular invasiveness of methicillin-resistant Staphylococcus aureus isolates. J Infect Dis 2007; 195:1678-85.
19. Josefsson E, McCrea KW, Ni Eidhin D, et al. Three new members of the serine-aspartate repeat protein multigene family of Staphylococcus aureus. Microbiology 1998; 144:3387-95.
20. Foster TJ, Höök M. Surface protein adhesins of Staphylococcus aureus. Trends Microbiol 1998; 6:484-8.
21. Hussain M, Herrmann M, von Eiff C, Perdreau-Remington F, Peters G. A 140-kilodalton extracellular protein is essential for the accumulation of Staphylococcus epidermidis strains on surfaces. Infect Immun 1997;65:519-24.
22. Huesca M, Peralta R, Sauder DN, Simor AE, McGavin MJ. Adhesion and virulence properties of epidemic Canadian methicillin-resistant Staphylococcus aureus strain 1: identification of novel adhesion functions associated with plasmin-sensitive surface protein. J Infect Dis 2002;185:1285-96.
23. Roche FM, Massey R, Peacock SJ, et al. Characterization of novel LPXTG-containing proteins of Staphylococcus aureus identified from genome sequences. Microbiology 2003; 149:643-54.
24. Roche FM, Meehan M, Foster TJ. The Staphylococcus aureus surface protein SasG and its homologues promote bacterial adherence to human desquamated nasal epithelial cells. Microbiology 2003; 149: 2759-67.
25. Juuti KM, Sinha B, Werbick C, Peters G, Kuusela PI. Reduced adherence and host cell invasion by methicillin-resistant Staphylococcus aureus expressing the surface protein Pls. J Infect Dis 2004; 189:1574-84.
26. Kozlowski M, Thatte V, Lau PC, Visentin LP, Iyer VN. Isolation and structure of the replicon of the promiscuous plasmid pCU1. Gene 1987;58:217-28.
27. Wann ER, Gurusiddappa S, Höök M. The fibronectin-binding MSCRAMM FnbpA of Staphylococcus aureus is a bifunctional protein that also binds to fibrinogen. J Biol Chem 2000;275:13863-71.
28. Harlow E, Lane D. Antibodies: a laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1988:53-138.
29. Vaudaux PE, Waldvogel FA, Morgenthaler JJ, Nydegger UE. Adsorption of fibronectin onto polymethylmethacrylate and promotion of Staphylococcus aureus adherence. Infect Immun 1984; 45:768-74.
30. Edgell CJ, McDonald CC, Graham JB. Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc Natl Acad Sei U S A 1983;80:3734-7.
31. 1. Cell Microbiol 1999; 1:101-17.
32. Wolz C, Goerke C, Landmann R, Zimmerli W, Fluckiger U. Transcription of clumping factor A in attached and unattached Staphylococcus aureus in vitro and during device-related infection. Infect Immun 2002; 70:2758-62.
33. Goerke C, Campana S, Bayer MG, Döring G, Botzenhart K, Wolz C. Direct quantitative transcript analysis of the agr regulon of Staphylococcus aureus during human infection in comparison to the expression profile in vitro. Infect Immun 2000;68:1304-11.
34. Smeltzer MS, Gillaspy AF, Pratt FL Jr, Thames MD, Iandolo JI. Prevalance and chromosomal map location of Staphylococcus aureus adesin genes. Gene 1997; 196:249-59.
35. Minhas T, Ludlam HA, Wilks M, Tabaqchali S. Detection by PCR and analysis of the distribution of a fibronectin-binding protein gene (fbn) among staphylococcal isolates. J Med Microbiol 1995;42:96-101.
36. Peacock SJ, Day NP, Thomas MG, Berendt AR, Foster TJ. Clinical isolates of Staphylococcus aureus exhibit diversity in fnb genes and adhesion to human fibronectin. J Infect 2000;41:23-31.
37. Vaudaux PE, Monzillo V, Francois P, Lew DP, Foster TJ, Berger-Bächi B. Introduction of the mec element (methicillin resistance) into Staphylococcus aureus alters in vitro functional activities of fibrinogen and fibronectin adhesins. Antimicrob Agents Chemother 1998;42:564-70.
38. Lally R, Woolfrey B. Clumping factor defective methicillin-resistant Staphylococcus aureus. Eur J Clin Microbiol 1984;3:151-2.
39. Uhlen M, Guss B, Nilsson B, Gatenbeck S, Philipson L, Lindberg M. Complete sequence of the staphylococcal gene encoding protein A: a gene evolved through multiple duplications. J Biol Chem 1984; 259: 1695-702.
40. McCrea KW, Hartford O, Davis S, et al. The serine-aspartate repeat (Sdr) protein family in Staphylococcus epidermidis. Microbiology 2000; 146:1535-46.
41. McDevitt D, Foster TJ. Variation in the size of the repeat region of the fibrinogen receptor (clumping factor) of Staphylococcus aureus strains. Microbiology 1995; 141:937-43.
42. Josefsson E, Juuti K, Bokarewa M, Kuusela P. The surface protein Pls of methicillin-resistant Staphylococcus aureus is a virulence factor in septic arthritis. Infect Immun 2005; 73:2812-7.