To mate or not to mate: A retrospective analysis of two-generation studies for evaluation of criteria to trigger additional mating in the extended one-generation design

Reproductive Toxicology

Volumn 28, Issue 2, 2009, Pages 203-208

  Beekhuijzen, Manon ^a   Zmarowski, Amy ^a   Emmen, Harry ^a   Frieling, Wilbert ^a  

^a Notox BV   (Netherlands)

Author keywords

Developmental toxicity; Extended one generation study; Reproductive toxicity; Two generation study

Indexed keywords

AGRICULTURAL CHEMICAL; BIOCIDE; INDUSTRIAL CHEMICAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREEDING; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; FEMALE; MALE; MATING; METHODOLOGY; NONHUMAN; PARENT; PROGENY; RAT; REPRODUCTIVE TOXICITY; RETROSPECTIVE STUDY; RISK ASSESSMENT;

ADMINISTRATION, ORAL; ANIMAL FEED; ANIMALS; COPULATION; FEMALE; MALE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; RATS; RATS, WISTAR; REPRODUCTION; RESEARCH DESIGN; RETROSPECTIVE STUDIES; TOXICITY TESTS; XENOBIOTICS;

ANIMALIA; RATTUS;

EID: 67650581726     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2009.04.015     Document Type: Article

References (8)

1. Organization for Economic Cooperation and Development. Health effects test guideline 416. Two-generation reproduction toxicity study. (Updated guideline, adopted 22 January 2001.) Environmental Directorate, Paris, France.
2. U.S. Environmental Protection Agency. Health Effects Test Guideline OPPTS 870.3800. Reproduction and fertility effects. EPA 712-C-98-208. Office of Prevention, Pesticides, and Toxic Substances, Washington, DC.
3. Cooper R.L., Lamb IV J.C., Barlow S.M., Bently K., Brady A.M., Doerrer N.G., et al. A tiered approach to life stages testing for agricultural chemical safety assessment. Crit Rev Toxicol 36 (2006) 69-98
4. van der Jagt K, Munn S, Torslov J, de Bruijn J. Alternative approaches can reduce the use of test animals under REACH. Addendum to JRC Report EUR 20863; 2004. 25 p.
5. Janer G., Hakkert B.C., Slob W., Vermeire T., and Piersma A.H. A retrospective analysis of the two-generation study: what is the added value of the second generation?. Reprod Toxicol 24 (2007) 97-102
6. Myers D.P., Willoughby C.R., Bottomley A.M., and Buschmann J. An analysis of the results from two-generation reproduction toxicity studies to assess the value of mating animals of the second (F1) generation for the detection of adverse treatment-related effects on reproductive performance. Reprod Toxicol 26 (2008) 47-50
7. Spielman H., and Vogel R. The extended 1-generation study (OECD 415), as a replacement of the mammalian 2-generation study (OECD 416). AATEX 14 (2008) 795-798
8. ECETOC. Document 45: Triggering and waiving criteria for the extended one-generation reproduction toxicity study. 2008 European Centre for Ecotoxicology and Toxicology of Chemicals, Brussels, Belgium.