Bone-targeting anthraquinone-diclofenac prodrugs with hydrolytic and bone affinity characteristics

Letters in Drug Design and Discovery

Volumn 6, Issue 5, 2009, Pages 393-396

  Duan, Yanbing ^a   Yu, Jia ^a   Liu, Haifeng ^a   Ji, Min ^a  

^a SOUTHEAST UNIVERSITY   (China)

Author keywords

Anthraquinone; Anti inflammatory; Bone affinity; Bone targeting; Hydrolytic; Prodrug

Indexed keywords

ANTHRAQUINONE; DIACETYLRHEIN; DICLOFENAC; HYDROXYAPATITE; PRODRUG; RHEIN;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; BONE; COLUMN CHROMATOGRAPHY; DRUG BINDING; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG STABILITY; DRUG SYNTHESIS; DRUG TARGETING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; SIMULATION;

EID: 67650552847     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/1570180810906050393     Document Type: Article

References (33)

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13. The spectra data of compounds 2, A and B.
14. Compound 2:
15. Yield: 85%. mp 200∼203 ̊C.
16. +451.0.
17. 3), 189.767, 181.225(2C, Ar=O).
18. IR(cm-1): 3434, 1759, 1724, 1680, 1593, 1372, 1327, 1280, 1254, 1204, 1074, 1025, 745, 701.
19. 2O (%): C59.86, H 4.07; Found: C 59.37, H 3.838.
20. Compound A:
21. Yield: 77%. mp 164∼166 ̊C.
22. + 606.0.
23. 2), 6.75(br, 1H, NH), 6.49∼8.37(m, 12H, Ar-H), 11.93, 11.96(s, 1H each, OH).
24. 2), 180.617(2C, Ar=O).
25. 1): 3374, 3081, 2905, 2360, 2340, 1723, 1674, 1634, 1451, 1418, 1375, 1291, 1270, 1233, 1199, 1140, 1093, 1020, 777, 749, 666.
26. 8 (%): C 61.40, H 3.49, N 2.31; Found: C 61.20, H 3.596, N 2.311.
27. Compound B:
28. Yield: 46%. mp 149∼151 ̊C.
29. + 728.3.
30. 2), 6.47∼8.79(m, 12H, Ar-H).
31. 2), 180.132, 180.479(2C, Ar=O).
32. -1): 3444, 3080, 2933, 2360, 1772, 1729, 1675, 1594, 1506, 1456, 1371, 1332, 1280, 1256, 1097, 1021, 921, 881, 770, 747.
33. 2O (%): C 59.33, H 3.84, N 1.98; Found: C60.81, H4.015, N2.199.