The ameriorating effects of grapefruit seed extract on testicular morphology and function of varicocelized rats;Efecto de aminoramiento del extracto de semilla de pomelo en la morfología y función testicular de ratas varicocelizadas

International Journal of Morphology

Volumn 26, Issue 4, 2008, Pages 1059-1064

  Saalu, L C ^a   Udeh, R ^b   Oluyemi, K A ^b   Jewo, P I ^a   Fadeyibi, L O ^a  

^a LAGOS STATE UNIVERSITY   (Nigeria)

^b IGBINEDION UNIVERSITY   (Nigeria)

Author keywords

Grapefruit seed extract; Infertility; Testis; Varicocele

Indexed keywords

EID: 67650544617     PISSN: 07179367     EISSN: 07179502     Source Type: Journal    
DOI: 10.4067/S0717-95022008000400042     Document Type: Article

References (16)

1. Akpantah, A. O.; Oremosu, A. A.; Ajala, M. O.; Noronha, C. C. & Okanlawon, A. O. The effect of crude extract of Garcinia kola seed on the histology and hormonal milieu of male Sprague-Dawley rats' reproductive organs. Nig. J. Health and Biomed. Sci., 2(1):40-46, 2003.
2. Henry, M. P.; Howard, S. S. & Turner, T. T. Repair of experimental varicoceles in rats. Long-term effects on testicular blood flow and temperature and Caudaepididymal sperm concentration and motility. J. Androl., 7:271-6, 1986.
3. Hendin, B. N.; Kolettis, P. N.; Sharma, R. K. & Thomas, A. Varicocele is associated with elevated spermatozoal reactive oxygen species production and diminished seminal plasma antioxidant capacity. J. Urol., 161:1831-4, 1999.
4. Hudson, R. W. The endocrinology of varicocele. Fertil. Steril., 49:199-208, 1988.
5. Lewis, S. E.; Boyle, P. M.; McKinney, K. A.; Young, I. S. & Thompson, W. Total antioxidant capacity of seminal plasma is different in fertile and infertile men. Fertil. Steril., 64:868-70, 1995.
6. Özdamar, A. S.; Soylu, A. G.; Çulha, M.; Özden, M. & Gökalp, A. Testicular oxidative stress effects of experimental varicocele in adolescent rats. Urol. Int., 73:343-7, 2004.
7. Ozokutan, B. H.; Kucukaydin, M.; Muhtaroglu, S. & Tekin, Y. The role of nitricoxide in testicular ischemia reperfusion injury. J. Pediatr. Surg., 35:101-3, 2000.
8. Saalu, L. C.; Togun, V. A.; Oyewopo, A. O. & Raji, Y. Artificial crypptorchidism and the moderating effect of melatonin in Sprague-Dawley rats. J. Appl. Sci., 6(14):2889-94, 2006.
9. Saalu, L. C.; Oluyemi, K. A.; & Omotuyi, I. O. a-Tocopherol (vitamin E) attenuates the testicular toxicity associated with experimental cryptorchidism in rats. Afr. J. Biotechnol., 6(12):1373-7, 2007.
10. Sachs, A. The Authoritative guide to grapefruit extract, Stay Healthy Naturally, Life rhythm. California, Medocino, 1997. pp. 775-95.
11. Santoro, G.; Romeo, C.; Impellizzeri, P.; Cutroneo, G. & Trimarchi, F. Nitricoxide synthase patterns in normal and varicocele testis in adolescents. BJU Int., 88:967-73, 2001.
12. Saypol, D. C.; Howards, S. S.; Turner, T. T. & Miller, E. D. Influence of Surgically induced Varicocele on testicular Blood flow, temperature and histology in adult rats and dogs. J. Clin. Invest., 68:39-45, 1981.
13. Semercioz, A.; Onur, R.; Ogras, S. & Orhan, I. Effect of melatonin on testicular tissue nitricoxide level and antioxidant enzyme activities in experimentally induced left varicocele. Neuro Endocrinol. Lett., 24(1/2):86-90, 2003.
14. Sharma, R. K. & Agarwal, A. Role of reactive oxygen species in male fertility. Urology, 48:835-8, 1996.
15. Sofikitis, N. & Miyagawa, I. Experimental models for the study of varicocele: A selected review. Jpn. J. Fertil. Steril., 38:168-77, 1992.
16. Suziki, N. & Sofikitis, N., Protective effects of antioxidants on testicular fractions of varicocelized rats. Yonago Acta Medica, 42:87-94, 1999.