α-Tocopherol (vitamin E) attenuates the testicular toxicity associated with experimental cryptorchidism in rats

African Journal of Biotechnology

Volumn 6, Issue 12, 2007, Pages 1373-1377

  Saalu, L C ^a   Oluyemi, K A ^b   Omotuyi, I O ^b  

^a LAGOS STATE UNIVERSITY   (Nigeria)

^b IGBINEDION UNIVERSITY   (Nigeria)

Author keywords

tocopherol; Crytorchidism; Infertility; Testis

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; HORMONE; TESTOSTERONE;

ABDOMINAL WALL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CRYPTORCHISM; HISTOLOGY; HORMONE BLOOD LEVEL; MALE; NONHUMAN; RAT; SEMEN ANALYSIS; SPRAGUE DAWLEY RAT; TESTIS INJURY; TESTIS SIZE; TESTIS WEIGHT; TESTOSTERONE BLOOD LEVEL;

RATTUS;

EID: 34347339601     PISSN: None     EISSN: 16845315     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Akpantah AO, Oremosu AA, Ajala MO, Noronha CC, Okanlawon AO (2003). The effect of crude extract of Garcinia kola seed on the histology and hormonal milieu of male Sprague-Dawley rats' reproductive organs. Niger. J. Health Biomed. Sci. 2(1): 40-46.
2. Chance B, Sites H, Boverts A (1979). Hydroperoxide metabolism in mammalian organs. Physiol. Rev. 59: 527-605.
3. Ezeasor DN (1985). Light and electron microscopic observations of the Leydig cells of the scrotal and abdominal testes of naturally unilateral cryptorchid WAD goats. Am. J. Vet. Res. 41: 27-40.
4. Grisham A, Mc Cord P (1996). Chemistry and cytotoxicity of reactive metabolites. Biology of oxygen radicals. AE Taylor, pp. 1-19.
5. th Edn., W. B. Saunders Company. Philadelphia. Pennysylvania, pp. 1006.
6. Hallwell B, Cutterlage JMC (1986). Oxygen free radicals and iron in relation to biology and medicine: Some problems and some Concepts. Arch. Biochem. Biophy. 246: 501-504.
7. Hallwell B (1989). Oxidants and the central nervous system. Some fundamental questions. Is oxidant damage relevant to Parkinson's Disease, Alzheimer's disease, traumatic injury or stroke? Acta Neurol Sci. 126: 23-33.
8. Jegou B, Peake RA, Iraby DC, De Krester DM (1984). Effect of the induction of experimental cryptorchidism and subsequent orchidopexy on testicular function in immature rats. Biol. Reprod. 30: 179-187.
9. Kappus H (1987). Oxidative stress in chemical toxicity. Arch. Tocicol. 60: 144-149.
10. Kawakami E (1995). Changes in peripheral plasma leutinizing hormone quality in normal and maturation. Lab. Anim. Sci. 45: 258-263.
11. Kumar DA, Derael R (1988). Physiological antioxidants and antioxidative enzymes in Vitamin E - deficient rats. Toxicol. Lett. 44: 47-54.
12. Noguchi T, Cantor A, Scott MC (1973). Mode of action of Selenium and Vit E. in prevention of oxidative stress in chicks. J. Nutr. 103: 1502-11.
13. Nambirajan LS, Agarwala AK, Dinda J, Mitra DM (2002). Fertility and Unilateral undescended testis in the rat model. III. Ultrastructural changes in the contralateral descended testis. Ped. Surg. Int. 18: 276-280.
14. Ono k, Sofikitis N (1997). A novel mechanism to explain the detrimental effects of left cryptorchidism on right testicular function. Yonago Acta Med. 40: 79-89.
15. Patkowski D, Jelen M, Crerni KJ (1992). The natural course of cryptorchidism in rats and efficacy of orchidopexy in its treatment before and after puberty. J Paediat. Surg. 27: 870-873.
16. Rikans LE, Moor DR, Snowden CD (1991). Sex - dependent differences in the effects of aging on antioxidant defences mechanisms of rat liver. Biochem. Biophy. Axta. 1074(1074): 195-200.
17. Saalu LC, Togun VA, Oyewopo AO, Raji Y (2006). Artificial cryptorchidism and the moderating effect of melatonin in Sprague - Dawley rats. J. Appl. Sci. 6 (14): 2889-2894.
18. Saalu LC, Adesanya AO, Oyewopo AO, Raji Y (2007). An evaluation of the deleterious effect of unilateral cryptorchidism on the contralateral normally descended testis. Sci. Res. Essays 2(3): 074-078.
19. st Rev. Edn. pp. 169-203.
20. Seppo T, Outi H, Sakari W (1996). Early treatment of cryptorchidism, semen quality and testicular endocrinology. J Urol. 156: 82-84.
21. Shakeel M, Farooqui M, Fakhri Al-Bagdalli, Milos D Houslay (2001). Surgically induced cryptorchidism related degenerative changes in spermatogonia are associated with loss of cyclic Adenosine monophosphate dependent phosphodiesterase type 4 in abdominal testis of rats. Biol. Reprod. 64: 1583-1589.
22. Suga T, Watanabe T, Matsumoto, Hortes Y (1984). Effects of long term Vit E deficiency and Restoration of rat hepatic peroxisones. Biochem. Biol. Phys. Acta. 794: 218-24.
23. Tellaloglus S (1994). Cryptorchidism is orchidopexy always. Preventive treatment for infertility. Acta Chir-Hungatic, 34: 195-201.
24. Waites GMH, Setchell BP (1990). Physiology of mammalian testis. In Marshall's Physiology of reproduction. Laming GE (Ed) Churchill Livingtone. London 2: 101-105.
25. Zhang RD, Wen XH, Kong LS, Deng XH (2002). Quantitative study of the effects of experimental cryptorchidism and subsequent orchidopexy on spermatogenesis in adult rabbit testis. Reproduction 124: 95-105.