Both endogenous and exogenous testosterone decrease myocardial STAT3 activation and SOCS3 expression after acute ischemia and reperfusion

Surgery

Volumn 146, Issue 2, 2009, Pages 138-144

  Wang, Meijing ^a   Wang, Yue ^a   Abarbanell, Aaron ^a   Tan, Jiangjing ^a   Weil, Brent ^a   Herrmann, Jeremy ^a   Meldrum, Daniel R ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANOLONE; FLUTAMIDE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CASTRATED MALE; DRUG RELEASE; FEMALE; GENE ACTIVATION; GENE EXPRESSION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANDROGEN ANTAGONISTS; ANIMALS; CASTRATION; DOWN-REGULATION; FEMALE; FLUTAMIDE; MALE; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; SEX CHARACTERISTICS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TESTOSTERONE;

EID: 67650526442     PISSN: 00396060     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.surg.2009.03.035     Document Type: Article

References (24)

1. Niagara M.I., Haider H., Jiang S., and Ashraf M. Pharmacologically preconditioned skeletal myoblasts are resistant to oxidative stress and promote angiomyogenesis via release of paracrine factors in the infarcted heart. Circ Res 100 (2007) 545-555
2. Uemura R., Xu M., Ahmad N., and Ashraf M. Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling. Circ Res 98 (2006) 1414-1421
3. Wang M., Baker L., Tsai B.M., Meldrum K.K., and Meldrum D.R. Sex differences in the myocardial inflammatory response to ischemia-reperfusion injury. Am J Physiol Endocrinol Metab 288 (2005) E321-E326
4. Wang M., Tsai B.M., Reiger K.M., Brown J.W., and Meldrum D.R. 17-beta-Estradiol decreases p38 MAPK-mediated myocardial inflammation and dysfunction following acute ischemia. J Mol Cell Cardiol 40 (2006) 205-212
5. Webb C.M., Adamson D.L., de Zeigler D., and Collins P. Effect of acute testosterone on myocardial ischemia in men with coronary artery disease. Am J Cardiol 83 (1999) 437-439
6. Wang M., Tsai B.M., Kher A., Baker L.B., Wairiuko G.M., and Meldrum D.R. Role of endogenous testosterone in myocardial proinflammatory and proapoptotic signaling after acute ischemia-reperfusion. Am J Physiol Heart Circ Physiol 288 (2005) H221-H226
7. Crisostomo P.R., Wang M., Wairiuko G.M., Morrell E.D., and Meldrum D.R. Brief exposure to exogenous testosterone increases death signaling and adversely affects myocardial function after ischemia. Am J Physiol Regul Integr Comp Physiol 290 (2006) R1168-R1174
8. Zaugg M., Jamali N.Z., Lucchinetti E., Xu W., Alam M., Shafiq S.A., et al. Anabolic-androgenic steroids induce apoptotic cell death in adult rat ventricular myocytes. J Cell Physiol 187 (2001) 90-95
9. Wang M., Tsai B.M., Crisostomo P.R., and Meldrum D.R. Tumor necrosis factor receptor 1 signaling resistance in the female myocardium during ischemia. Circulation 114 Suppl 1 (2006) I282-I289
10. Wang M., Crisostomo P.R., Markel T.A., Wang Y., and Meldrum D.R. Mechanisms of sex differences in TNFR2-mediated cardioprotection. Circulation 118 Suppl 14 (2008) S38-S45
11. Welte T., Zhang S.S., Wang T., Zhang Z., Hesslein D.G., Yin Z., et al. STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci U S A 100 (2003) 1879-1884
12. Wang M., Zhang W., Crisostomo P., Markel T., Meldrum K.K., Fu X.Y., et al. Endothelial STAT3 plays a critical role in generalized myocardial proinflammatory and proapoptotic signaling. Am J Physiol Heart Circ Physiol 293 (2007) H2101-H2108
13. Hilfiker-Kleiner D., Hilfiker A., Fuchs M., Kaminski K., Schaefer A., Schieffer B., et al. Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury. Circ Res 95 (2004) 187-195
14. Negoro S., Kunisada K., Fujio Y., Funamoto M., Darville M.I., Eizirik D.L., et al. Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation of manganese superoxide dismutase. Circulation 104 (2001) 979-981
15. Negoro S., Kunisada K., Tone E., Funamoto M., Oh H., Kishimoto T., et al. Activation of JAK/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction. Cardiovasc Res 47 (2000) 797-805
16. Wang M., Markel T., Crisostomo P., Herring C., Meldrum K.K., Lillemoe K.D., et al. Deficiency of TNFR1 protects myocardium through SOCS3 and IL-6, but not p38 MAPK or IL-1 beta. Am J Physiol Heart Circ Physiol 292 (2007) H1694-H1699
17. Tunstall-Pedoe H., Morrison C., Woodward M., Fitzpatrick B., and Watt G. Sex differences in myocardial infarction and coronary deaths in the Scottish MONICA population of Glasgow 1985 to 1991. Presentation, diagnosis, treatment, and 28-day case fatality of 3991 events in men and 1551 events in women. Circulation (1996) 931981-931992
18. Remmers D.E., Wang P., Cioffi W.G., Bland K.I., and Chaudry I.H. Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males. Am J Physiol 273 (1997) H2919-H2925
19. Barp J., Araujo A.S., Fernandes T.R., Rigatto K.V., Llesuy S., Bello-Klein A., et al. Myocardial antioxidant and oxidative stress changes due to sex hormones. Braz J Med Biol Res 35 (2002) 1075-1081
20. Wang M., Zhang W., Crisostomo P., Markel T., Meldrum K.K., Fu X.Y., et al. Sex differences in endothelial STAT3 mediate sex differences in myocardial inflammation. Am J Physiol Endocrinol Metab 293 (2007) E872-E877
21. Bromberg J. Stat proteins and oncogenesis. J Clin Invest 109 (2002) 1139-1142
22. Schwarze M.M., and Hawley R.G. Prevention of myeloma cell apoptosis by ectopic bcl-2 expression or interleukin 6-mediated up-regulation of bcl-xL. Cancer Res 55 (1995) 2262-2265
23. Jo D., Liu D., Yao S., Collins R.D., and Hawiger J. Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis. Nat Med 11 (2005) 892-898
24. Yasukawa H., Ohishi M., Mori H., Murakami M., Chinen T., Aki D., et al. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol 4 (2003) 551-556