Modulation of the structure, catalytic activity, and fidelity of African Swine fever virus DNA polymerase X by a reversible disulfide switch

Journal of Biological Chemistry

Volumn 284, Issue 27, 2009, Pages 18434-18444

  Voehler, Markus W ^a   Eoff, Robert L ^a   McDonald, W Hayes ^a   Guengerich, F Peter ^a   Stone, Michael P ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFRICAN SWINE FEVER VIRUS; BASE EXCISION REPAIRS; CATALYTIC ACTIVITY; CATALYTIC METALS; CONFORMATIONAL CHANGE; DISULFIDE BONDS; DISULFIDE LINKAGES; DNA POLYMERASE; FUNCTIONAL PROPERTIES; INTERCONVERSION; KINETIC ANALYSIS; OH GROUP; PHOSPHORYL TRANSFER; PRIMER TERMINUS; REDOX STATE; STEADY-STATE KINETICS; STRUCTURAL SIMILARITY; TERNARY STRUCTURE; TERTIARY STRUCTURES; VIRAL GENES;

AMINES; AMINO ACIDS; BINDING ENERGY; DNA; GENES; MASS SPECTROMETRY; METAL IONS; NUCLEIC ACIDS; ORGANIC ACIDS; POLYMERS; SPECTROSCOPIC ANALYSIS;

BINDING SITES;

DISULFIDE; DNA POLYMERASE; DNA POLYMERASE X; METAL ION; UNCLASSIFIED DRUG;

AFRICAN SWINE FEVER VIRUS; ARTICLE; BINDING SITE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISULFIDE BOND; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME REGULATION; ENZYME STRUCTURE; MASS SPECTROMETRY; NITROGEN NUCLEAR MAGNETIC RESONANCE; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN TERTIARY STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; STEADY STATE;

AFRICAN SWINE FEVER VIRUS; CATALYSIS; DISULFIDES; DNA, VIRAL; DNA-DIRECTED DNA POLYMERASE; ENZYME ACTIVATION; GUANOSINE TRIPHOSPHATE; KINETICS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OXIDATION-REDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; VIRUS REPLICATION;

AFRICAN SWINE FEVER VIRUS;

EID: 67650519102     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.012542     Document Type: Article

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