Review: Effect of glucose-insulin-potassium infusion on mortality in critical care settings: A systematic review and meta-analysis

Journal of Clinical Pharmacology

Volumn 49, Issue 7, 2009, Pages 758-767

  Puskarich, Michael A ^a   Runyon, Michael S ^a   Trzeciak, Stephen ^b   Kline, Jeffrey A ^a   Jones, Alan E ^a  

^a CAROLINAS MEDICAL CENTER   (United States)

^b Department of Anesthesiology   (United States)

Author keywords

Anesthesiology; Clinical research; Clinical trials; Critical care; Emergency medicine

Indexed keywords

GLUCOSE; INSULIN; POTASSIUM; GLUCOSE INSULIN POTASSIUM CARDIOPLEGIC SOLUTION; GLUCOSE-INSULIN-POTASSIUM CARDIOPLEGIC SOLUTION;

ACUTE HEART INFARCTION; AORTA VALVE REPLACEMENT; AORTIC VALVE REPAIR; CARDIOVASCULAR SURGERY; CLINICAL TRIAL; CONTINUOUS INFUSION; CORONARY ARTERY BYPASS GRAFT; GLUCOSE INFUSION; HUMAN; HYPERKALEMIA; HYPOGLYCEMIA; INSULIN INFUSION; INTENSIVE CARE; INTENSIVE CARE UNIT; META ANALYSIS; MITRAL VALVE REPLACEMENT; MORTALITY; POTASSIUM INTAKE; REVIEW; SEPTIC SHOCK; SHOCK; SURGICAL PATIENT; SYSTEMATIC REVIEW; TREATMENT OUTCOME; CARDIOVASCULAR DISEASE; CRITICAL ILLNESS; HEART INFARCTION; RANDOMIZED CONTROLLED TRIAL; STATISTICS;

CARDIOVASCULAR DISEASES; CRITICAL CARE; CRITICAL ILLNESS; GLUCOSE; HUMANS; INSULIN; MYOCARDIAL INFARCTION; POTASSIUM; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SHOCK, SEPTIC;

EID: 67650475389     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1177/0091270009334375     Document Type: Review

References (53)

1. Fishleder BL, Frieldand C., De MA, et al. Effects of an intravenous infusion of a potassium-glucose-insulin solution on the electrocardiographic signs of myocardial infarction: a preliminary clinical report. Am J Cardiol. 1962 ; 9: 166-181.
2. Mehta SR, Yusuf S., Diaz R., et al. Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: the CREATE-ECLA randomized controlled trial. JAMA. 2005 ; 293: 437-446.
3. Fath-Ordoubadi F., Beatt KJ Glucose-insulin-potassium therapy for treatment of acute myocardial infarction: an overview of randomized placebo-controlled trials. Circulation. 1997 ; 96: 1152-1156. (Pubitemid 27344217)
4. Bothe W., Olschewski M., Beyersdorf F., et al. Glucose-insulin-potassium in cardiac surgery: a meta-analysis. Ann Thorac Surg. 2004 ; 78: 1650-1657. (Pubitemid 39423531)
5. Law WR, McLane MP, Raymond RM Effect of insulin on myocardial contractility during canine endotoxin shock. Cardiovasc Res. 1988 ; 22: 777-785. (Pubitemid 18268706)
6. Raymond RM, McLane MP, Law WR, et al. Myocardial insulin resistance during acute endotoxin shock in dogs. Diabetes. 1988 ; 37: 1684-1688. (Pubitemid 19004954)
7. Vary TC, Hazen S., Vary TC, et al. Sepsis alters pyruvate dehydrogenase kinase activity in skeletal muscle. Mol Cell Biochem. 1999 ; 198: 113-118. (Pubitemid 29414529)
8. Vary TC Sepsis-induced alterations in pyruvate dehydrogenase complex activity in rat skeletal muscle: effects on plasma lactate [abstract]. Shock. 1996 ; 6: 89-94. (Pubitemid 126727745)
9. Vary TC, Siegel JH, Nakatani T., et al. Effect of sepsis on activity of pyruvate dehydrogenase complex in skeletal muscle and liver. Am J Physiol. 1986 ; 250: E634 - E640.
10. Kobayashi K., Neely JR Effects of increased cardiac work on pyruvate dehydrogenase activity in hearts from diabetic animals. J Mol Cell Cardiol. 1983 ; 15: 347-357.
11. Hutson NJ, Kerbey AL, Randle PJ, et al. Regulation of pyruvate dehydrogenase by insulin action. Prog Clin Biol Res. 1979 ; 31: 707-719. (Pubitemid 10153084)
12. Kumar A., Thota V., Dee L., et al. Tumor necrosis factor alpha and interleukin 1beta are responsible for in vitro myocardial cell depression induced by human septic shock serum. J Exp Med. 1996 ; 183: 949-958. (Pubitemid 26113964)
13. Higgins JPT, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions. Version 4.2.6. Chichester, UK: Wiley; 2006.
14. Schipke JD, Friebe R., Gams E. Forty years of glucose-insulin-potassium (GIK) in cardiac surgery: a review of randomized, controlled trials. Eur J Cardiothorac Surg. 2006 ; 29: 479-485.
15. Pittas AG, Siegel RD, Lau J. Insulin therapy for critically ill hospitalized patients: a meta-analysis of randomized controlled trials. Arch Intern Med. 2004 ; 164: 2005-2011. (Pubitemid 39390557)
16. Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ. 2003 ; 327: 557-560. (Pubitemid 37088507)
17. Hunter JE, Schmidt FL Fixed effects vs random effects meta-analysis models: implications for cumulative research knowledge. International Journal of Selection and Assessment. 2000 ; 8: 275-292. (Pubitemid 33203822)
18. Terrin N., Schmid CH, Lau J. In an empirical evaluation of the funnel plot, researchers could not visually identify publication bias. J Clin Epidemiol. 2005 ; 58: 894-901. (Pubitemid 41115773)
19. Tang JL, Liu JL Misleading funnel plot for detection of bias in meta-analysis. J Clin Epidemiol. 2000 ; 53: 477-484. (Pubitemid 30254343)
20. Pentecost BL, Mayne NM, Lamb P. Controlled trial of intravenous glucose, potassium, and insulin in acute myocardial infarction. Lancet. 1968 ; 1: 946-948.
21. Rackley CE, Rogers WJ, McDaniel HG, et al. Randomized study of glucose insulin potassium in patients with acute myocardial infarction [abstract]. Clin Res. 1976 ; 24: 421A.
22. Stanley AWH Jr, Prather JW Glucose-insulin-potassium, patient mortality and the acute myocardial infarction: results from a prospective randomized study [abstract]. Circulation 1978 ; 58 (Supp 4 II): II - 61.
23. Thys JP The value of the polarizing treatment in myocardial infarction. Acta Cardiol. 1974 ; 29: 19-29.
24. Mantle JA, Rogers WJ, Smith LR, et al. Clinical effects of glucose-insulin-potassium on left ventricular function in acute myocardial infarction: results from a randomized clinical trial. Am Heart J. 1981 ; 102: 313-324.
25. Rogers, J., McDaniel, HG, Mantle, JA, et al. Glucose-insulin-potassium infusion in acute myocardial infarction-results of a prospective randomized study [abstract]. Clin Res. 1982 ; 30: 216A. (Pubitemid 13238486)
26. Oldfield GS, Commerford PJ, Opie LH Effects of preoperative glucose-insulin-potassium on myocardial glycogen levels and on complications of mitral valve replacement. J Thoracic Cardiovas Surg. 1986 ; 91: 874-878. (Pubitemid 16092989)
27. Coleman GM, Gradinac S., Taegtmeyer H., et al. Efficacy of metabolic support with glucose-insulin-potassium for left ventricular pump failure after aortocoronary bypass surgery. Circulation. 1989 ; 80: 191-196.
28. Lazar HL, Philippides G., Fitzgerald C., et al. Glucose-insulin-potassium solutions enhance recovery after urgent coronary artery bypass grafting. J Thoracic Cardiovas Surg. 1997 ; 113: 354-360.
29. Lazar HL, Chipkin S., Philippides G., et al. Glucose-insulin-potassium solutions improve outcomes in diabetics who have coronary artery operations. Ann Thorac Surg. 2000 ; 70: 145-150. (Pubitemid 30485739)
30. Lazar HL, Chipkin SR, Fitzgerald CA, et al. Tight glycemic control in diabetic coronary artery bypass graft patients improves perioperative outcomes and decreases recurrent ischemic events. Circulation. 2004 ; 109: 1497-1502. (Pubitemid 38420177)
31. Turkoz A., Toprak HI, Sari S., et al. Glucose-insulin-potassium solution before cardiopulmonary bypass in coronary artery surgery. Turk Anest Rean Cem Mecnuiasi. 2000 ; 28: 361-365. (Pubitemid 30782834)
32. Lindholm L., Bengtsson A., Hansdottir V., et al. Insulin (GIK) improves central mixed and hepatic venous oxygenation in clinical cardiac surgery. Scand Cardiovasc. 2001 ; 35: 347-352. (Pubitemid 34100816)
33. Smith A., Grattan A., Harper M., et al. Coronary revascularization: a procedure in transition from on-pump to off-pump? The role of glucose-insulin-potassium revisited in a randomized, placebo-controlled study. J Cardiothorac Vasc Anesth. 2002 ; 16: 413-420. (Pubitemid 34839695)
34. Lell WA, Nielsen VG, McGiffin DC, et al. Glucose-insulin-potassium infusion for myocardial protection during off-pump coronary artery surgery. Ann Thorac Surg. 2002 ; 73: 1246-1251. (Pubitemid 34275914)
35. Pache J., Kastrati A., Mehilli J., et al. A randomized evaluation of the effects of glucose-insulin-potassium infusion on myocardial salvage in patients with acute myocardial infarction treated with reperfusion therapy. Am Heart J. 2004 ; 148: e3.
36. Krljanac G., Vasiljevic Z., Radovanovic M., et al. Effects of glucose-insulin-potassium infusion on ST-elevation myocardial infarction in patients treated with thrombolytic therapy. Am J Cardiol. 2005 ; 96: 1053-1058. (Pubitemid 41416594)
37. Koskenkari JK, Kaukoranta PK, Kiviluoma KT, et al. Metabolic and hemodynamic effects of high-dose insulin treatment in aortic valve and coronary surgery. Ann Thorac Surg. 2005 ; 80: 511-517. (Pubitemid 41019470)
38. Ranasinghe AM, Quinn DW, Pagano D., et al. Glucose-insulin-potassium and tri-iodothyronine individually improve hemodynamic performance and are associated with reduced troponin I release after on-pump coronary artery bypass grafting. Circulation. 2006 ; 114: 1245-1250.
39. Quinn DW, Pagano D., Bonser RS, et al. Improved myocardial protection during coronary artery surgery with glucose-insulin-potassium: a randomized controlled trial. J Thorac Cardiovasc Surg. 2006 ; 131: 34-42.
40. Yanhui L., Zhang L., Zhang H., et al. The effects of high concentration glucose-insulin-potassium (GIK) on the hemodynamics of patients with acute myocardial infarction. Chin J Emerg Med. 2006 ; 15: 152-155. (Pubitemid 43263483)
41. Zuurbier CJ, Hoek FJ, van DJ, et al. Perioperative hyperinsulinaemic normoglycaemic clamp causes hypolipidaemia after coronary artery surgery. Br J Anaesth. 2008 ; 100: 442-450. (Pubitemid 351773611)
42. Clowes GH, Jr. Energy metabolism in sepsis: treatment based on different patterns in shock and high output stage. Ann Surg. 1974 ; 179: 684-696.
43. Weisul JP, O'Donnell TF Jr, Stone MA, et al. Myocardial performance in clinical septic shock: effects of isoproterenol and glucose potassium insulin. J Surg Res. 1975 ; 18: 357-363.
44. Vincent J-L., Dufaye P., Berre J., et al. Infusion of glucose and insulin in circulatory shock. Crit Care Med. 1981 ; 9: 209.
45. Bronsveld W., van den Bos G. Use of glucose-insulin-potassium (GIK) in human septic shock. Crit Care Med. 1985 ; 13: 566-570. (Pubitemid 15233965)
46. Mauritz W., Schindler I., Zadrobilek E., et al. Glucose-potassium-insulin in hypodynamic septic shock. Anaesthesist. 1986 ; 35: 623-627. (Pubitemid 17114129)
47. Hamdulay SS, Al-Khafaji A., Montgomery H. Glucose-insulin and potassium infusions in septic shock. Chest. 2006 ; 129: 800-804.
48. Archer LT, Beller BK, Drake JK, et al. Reversal of myocardial dysfunction in endotoxin shock with insulin. Can J Physiol Pharmacol. 1978 ; 56: 132-138. (Pubitemid 8284298)
49. Manny J., Rabinovici N., Manny N., et al. Effect of glucose-insulin- potassium on survival in experimental endotoxic shock. Surg Gynecol Obstet. 1978 ; 147: 405-409. (Pubitemid 9008513)
50. Bronsveld W., van Lambalgen AA, van den Bos GC, et al. Ventricular function, hemodynamics, and oxygen consumption during infusions of blood and glucose-insulin-potassium (GIK) in canine endotoxin shock. Circ Shock. 1982 ; 9: 145-156. (Pubitemid 12073392)
51. Tuynman HA, Thijs LG, Straub JP, et al. Effects of glucose-insulin- potassium (GIK) on the position of the oxyhemoglobin dissociation curve, 2.3-diphosphoglycerate, and oxygen consumption in canine endotoxin shock. J Surg Res. 1983 ; 34: 246-253. (Pubitemid 13163170)
52. Bronsveld W., van Lambalgen AA, van den Bos GC, et al. Effects of glucose-insulin-potassium (GIK) on myocardial blood flow and metabolism in canine endotoxin shock. Circ Shock. 1984 ; 13: 325-340. (Pubitemid 14074913)
53. Shea BJ, Grimshaw JM, Wells GA, et al. Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol. 2007 ; 7: 10.