Hypoglycaemia and improved testicular parameters in Sesamum radiatum treated normo-glycaemic adult male Sprague Dawley rats

African Journal of Biotechnology

Volumn 8, Issue 12, 2009, Pages 2878-2886

  Shittu Lukeman, A J ^a   Shittu Remilekun, K ^b   Olufemi, Ogundipe ^c   Tayo Adetokunbo, O ^d   Osunubi Abraham, A A ^d  

^a UNIVERSITY OF ABUJA   (Nigeria)

^b Bolomedics Laboratories Lagos   (Nigeria)

^c NOTTINGHAMSHIRE HEALTHCARE NHS TRUST   (United Kingdom)

^d LAGOS STATE UNIVERSITY   (Nigeria)

Author keywords

Epithelial hyperplasia; Glucose profile; Sesame phytoestrogens; Stereology; Testis

Indexed keywords

FOLLITROPIN; GLUCOSE; PLANT EXTRACT; SESAME RADIATUM EXTRACT; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MEGADOSE; EPITHELIUM CELL; FOLLITROPIN BLOOD LEVEL; GLUCOSE BLOOD LEVEL; LOW DRUG DOSE; MALE; NONHUMAN; PLANT LEAF; RAT; SESAME; SESAME RADIATUM; SPRAGUE DAWLEY RAT; TESTIS WEIGHT; TESTOSTERONE BLOOD LEVEL;

RATTUS; SESAMUM INDICUM; SESAMUM RADIATUM;

EID: 67650468490     PISSN: None     EISSN: 16845315     Source Type: Journal    
DOI: None     Document Type: Article

References (63)

1. Adlercreutz H (1991). Diet and sex hormones meyabolism. In: Rowland FR, ed. Nutrition, toxicity and cancer. Boca Raton FL. CRC Press, pp. 137-194.
2. Ahmed T, Shittu LAJ, Bankole MA, Adesanya OA, Bankole MN, Shittu RK, Ashiru OA (2005). Comparative antimicrobial studies of selected antibiotics/antifungal with extracts of sesame radiatum against some common microorganisms. Scientific Research and Essays, March (IN PRESS).
3. Alberti KGMM, Press CM (1982). The biochemistry of the complications of diabetes mellitus. In: Keen M, Jarrett J editors. Complications of diabetes. London: Edward Arnold Ltd. 1982: 231-270.
4. American Physiological Society (2002). Guiding principles for research involving animals and human beings. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 283: R281-R283.
5. Atkinson M (1979). Herbs for your Health. Dalesman Books New York.
6. Babu Padavala Ajay, Gadde Suneetha, Radha Boddepalli, Vedurupaka Vasantha Lakshmi, Talluru Sudha Rani, Yellapu RamBabu and Kolli Srinivas, (2006). A database of 389 medicinal plants for diabetes. Bioinformation, 1(4): 130-213
7. Bankole Munir A, Shittu Lukeman AJ, Ahmed Titilade A, Bankole Marian N, Shittu Remilekun K, Ashiru Oladapo A (2007). Synergistic Antimicrobial Activities of Phytoestrogens In Crude Extracts Of Two Sesame Species Against Some Common Pathogenic Microorganism. Afr. J. Traditional, Complimentary Alternative Med. 4(4): 427-433.
8. Ballester Joan, Carmen Muñoz M, Domínguez J, Rigau T, Guinovart J, Joan E, Rodríguez G (2004). Insulin-Dependent Diabetes Affects Testicular Function by FSH- and LH-Linked Mechanisms, J. Androl. 25(5).
9. Beckstrom-Sternberg SM, Duke JA (1994). The phytochemical database. ars-genome.cornell.edu/cgi-bin/WebAce/webace?db=phytochemdb. (Data version July).
10. Benítez A, Pérez Díaz J (1985). Effect of streptozotocin-diabetes and insulin treatment on regulation of Leydig cell function in the rat. Horm. Metab. Res. 17: 5-7.
11. Borland K, Mita M, Oppenheimer CL, Blinderman LA, Massagué J, Hall PF, Czech MP (1984). The actions of insulin-like growth factor-I and -II on cultured Sertoli cells. Endocrinol. 114: 240-246. (Pubitemid 14221896)
12. Davidson MB (1998). Diabetes Mellitus: Diagnosis and Treatment, fourth ed. W.B. Saunders Company, Philadelphia. In Drucker, D.J., 1998. The glucagons-like peptides. Diabetes, 47: 159-169.
13. Don F, Cameron Frederick T, David M, Drylie D (1985). Interstitial compartment pathology and spermatogenic disruption in testes from impotent diabetic men, Anatomical Record, 213(1): 53-62. (Pubitemid 16255614)
14. Gill LS (1992). Ethnomedical uses of plants in Nigeria, Uniben Press, Edo State Nigeria, p. 212.
15. Guneli E, Tugyan K, Ozturk H. M. Gumustekinc, S. Cilakerb, N. Uysald (2008). Effect of Melatonin on Testicular Damage in Streptozotocin-Induced Diabetes Rats. Euro. Surg. Res. 40: 354-360.
16. Helal Eman GE, Shahat Mohamed MA (2006). Hypolipidimic effect of some medicinal plants on diabetic rats, Egyptian J. Hospital Med. 23: 200-211.
17. Hess RA, Carnes K (2004). The role of estrogen in testis and the male reproductive tract: a review and species comparison. review and species comparison. Anim. Reprod. 1: 5-30.
18. Huerta V, Mihalik K, Maitin V, Crixell SH, Vattem DA (2007). Effect of Central/South American medicinal plants on energy harvesting ability of the mammalian GI tract. J. Med. Plants Res. 1(2): 038-049.
19. Hunnt JV, Smith CCT, Wolff SP (1999). Auto oxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose. Diabetes, 39: 1420-1424.
20. Hurtado de Catalfo G, Nelva I, De Gómez Dumm T (1998). Lipid dismetabolism in Leydig and Sertoli cells isolated from streptozotocin-diabetic rats. Int. J. Biochem. Cell Biol. 30: 1001-1010.
21. Hutson JC, Stocco DM, Campbell GT, Wagoner J (1983). Sertoli cell function in diabetic, insulin-treated diabetic, and semi-starved rats. Diabetes, 32: 112-116. (Pubitemid 13180342)
22. International Diabetes Federation (IDF) (2006). The International Working Group on the Diabetic Foot.
23. Jakus V (2000). The role of free radicals, oxidative stress and antioxidant systems in diabetic vascular disease. Bratisl Lek Listy, 101: 541-551.
24. Jayalekshmy A, Arumugham C, Suja KP (2001). Process for extraction of antioxidants from sesame seed/cake. US Patent Appl. 60/04.004.
25. Kato MJ, Chu A, Davin LB, Lewis NG (1998). Biosynthesis of antioxidant lignans in Sesamum indicum seeds. Phytochem. 47: 583-591. (Pubitemid 28051422)
26. Khan S, Teerds K, Dorrington J (1992). Growth factor requirements for DNA synthesis by Leydig cells from the immature rat. Biol. Reprod. 46: 335-341.
27. Nagi M, Kochhar A (2005). Effect of Supplementation of Traditional Medicinal Plants on Blood Glucose in Non-Insulin-Dependent Diabetics: A Pilot Study, J. Medicinal Food, December 1, 8(4): 545-549.
28. Konan AR, Datte JY, Yapo PA (2008). Nitric oxide pathway mediated relaxant effects of aqueous sesame leaves extract (Sesamum radiatum Schum & Thonn) in the guinea pig isolated aorta smooth muscle. BMC Complimentary Altern. Med., www.iomedcentral.com/1472 6882 /8/:23.
29. Laurentin H, Karlovsky P (2005). Investigation of Genetic Variability among Twenty Sesame (Sesamum indicum L.), Venezuelan Cultivars Using Amplified Fragments Length Polymorphisms (AFLP), The Global Food & Product Chain-Dynamics, innovations, Conflicts, Strategies, Deutscher Tropentag, Hohenheim, October 11-13.
30. Namiki M (1995). The chemistry and physiological functions of sesame. Food Rev. Int. 11: 281-329.
31. Nesbitt PD, Lam Yi, Thompson LU (1999). Human metabolism of mammalian lignans precursors in raw and processed flaxseed. Am. J. Clin. Nutr. 69: 549-555.
32. Meachem SJ, Wreford Robertson NG, McLachlan RI (1997). Androgen action on restoration of spermatogenesis in adult rats: effect of human chorionic gonadotrophic, testosterone and flutamide administration on germ cell number. Int. J. androl. 20(1): 70. (Pubitemid 27390291)
33. Mita M, Borland K, Price JM, Hall PF (1985). The influence of insulin and insulin-like growth factor-I on hexose transport by Sertoli cells. Endocrinol. 116: 987-992. (Pubitemid 15136953)
34. Mohamed B, Hassane M, Abdelkhaleq L (2002). Medicinal plants used in the treatment of diabetes in Morocco. Letter to editor, 10(1): April. http: // ijod .uaeu .ac.ae/iss-1001/e.htm, accessed August, 2008.
35. Murray FT, Cameron DF, Orth JM (1983). Gonadal dysfunction in the spontaneous diabetic BB rat. Metabolism, 32: 141-147.
36. Mouton PR (2002). Principles and Practices of Unbiased Stereology- Introduction for Bioscientists. Baltimore, Maryland: The John Hopkins University Press, pp. 211-214.
37. Obiajunwa EIFM, Adebiyi L, Omode PE (2005). Determination of Essential Minerals and Trace Elements in Nigerian Sesame Seeds, Using TXRF Technique. Pak. J. Nutri. 4(6): 393-395.
38. Oliveira C, Nie R, Carnes K, Franca LR, Prins GS, Saunders PTK, Hess RA (2003). The antiestrogen ICI 182, 780 decreases the expression of estrogen receptor-alpha but has no effect on estrogen receptorbeta and androgen receptor in rat efferent ductules. Reprod. Biol. Endocrinol. 1: 75.
39. Orth JM, Murray FT, Bardin CW (1979). Ultrastructural changes in Leydig cells of streptozotocin-induced diabetic rats. Anat. Rec. 195: 415-430. (Pubitemid 10210896)
40. Palaiseul J (1983). Grandmother's Secrets. Her Green Guide to Health from Plants, Cox and Wyman Ltd. Reading, p. 107-110.
41. Paz G, Homonnai ZT (1979). Leydig cell function in streptozotocininduced diabetic rats. Experientia, 35: 1412-1413. (Pubitemid 10236099)
42. 2+-ATPase activity in heart and liver of streptozotocindiabetic rats: comparison with vitamin E. Biochim. Biophys. Acta 1588, 71-78
43. Penalvo JL, Heinonen SM, Aura AM, Adlercruetz H (2005). Dietary Sesamin is converted to enterolactone in humans. J. Nutr. pp. 1056-1062. www.jn.nutrition.org, March 20, 2008. (Pubitemid 40645290)
44. Punitha R, Vasudevan K, Manoharan S (2006). Effect of Pongamia pinnata flowers on blood glucose and oxidative stress in alloxan induced diabetic rats. Indian J. Pharmacol., 38(1): 62-63.
45. Ramesh B, Saravanan R, Pugalendi KV (2005). Influence of Sesame Oil on Blood Glucose, Lipid Peroxidation, and Antioxidant Status in Streptozotocin Diabetic Rats. J. Med. Food, September 1, 8(3): 377-381.
46. Ribnicky DM, Pouleva A, Watfordb M, Cefaluc WT, Raskin I (2006). Antihyperglycemic activity of TarralinTM, an ethanolic extract of Artemisia dracunculus L. Phytomed. 13: 550-557. (Pubitemid 44224045)
47. Shittu LAJ, Bankole MA, Ahmed T, Aile K, Akinsanya MA, Bankole MN, Shittu RK, Ashiru OA (2006a). Differential antimicrobial activity of the various crude leaves extracts of Sesame radiatum against some common pathogenic micro-organisms. Scientific Res. Essay, 1(3): 108-111.
48. Shittu LAJ, Shittu RK, Osinubi AAA, Ashiru OA (2006b). Stereological evidences of epithelial hypoplasia of Seminiferous tubules induced by mesterolone in adult Sprague-Dawley rats. Afr. J. Endocrinol. Metab. 7: 21-25.
49. Shittu LAJ (2006). The effect of the aqueous crude leaves extract of Sesamum radiatum compared to Mesterolone (proviron) on the adult male Sprague Dawley rats testis and epididymis. MSc Dissertation, Lagos State University, College of Medicine, Ikeja, Lagos, Nigeria. August , 2006.
50. Shitu LAJ, Bankole MA, Ahmed T, Bankole MN, Shittu RK, Saalu CL, Ashiru OA (2007a). Antibacterial and Antifungal Activities of Essential Oils of Crude Extracts of Sesame Radiatum against Some Common Pathogenic Micro-organisms. IJPT, 6: 165-170.
51. Shittu LAJ, Bankole MA, Oguntola JA, Ajala O, Shittu RK, Ogundipe OA , Bankole MN, Ahmed T, Ashiru OA (2007b). Sesame Leaves Intake Improve and Increase Epididymal Spermatocytes Reserve In Adult Male Sprague Dawley Rat. Scientific Res. Essays, 2(8): 319-324.
52. Shittu LAJ, Bankole MA, Ogundipe OA, Fakade AK, Shittu RK, Bankole Marian N, Ahmed T, Tayo AO, Ashiru OA (2007c). Weight reduction with improvement of serum lipid profile and ratios of Sesame radiatum leaves diet in a nonobses Sprague Dawley Rat. Afr. J. Biotechnol. 6(21): 2428-2433.
53. Shittu LAJ, Shittu R K, Adesite S O, Ajala M O, Bankole M A, Benebo A S, Tayo A O, Ogundipe O A, Ashiru O A (2008). Sesame Radiatum Phytoestrogenic Lignans Enhances Testicular Activity In Adult Male Sprague Dawley Rat Testis. Int. J. Morphol. 26(3):643-652.
54. Thompson LU, Robb P, Serraino M, Cheung F (1991). Mammalian lignan production from various foods. Nutr. Cancer, 16: 43-52.
55. Trinder P (1969). Mono reagent enzymatic glucose. In clinical chemistry, WB Saunders, Philadelphia/London, pp. 24-27.
56. Vuksan V, Sievenpiper JL, Xu Z, Wong EYY, Jenkins AL, Beljan-Zdravkovic U, Leiter LA, Josse RG, Stavro MP (2001). Konjac-Mannan and American Ginseng: Emerging Alternative Therapies for Type 2 Diabetes Mellitus. Am. J. Clin. Nutr. 20: 370S-380S.
57. Wadood N, Nisar M, Rashid A, Wadood A, Nawab G, Khan A (2007). Effect of a compound recipe (medicinal plants) on serum insulin levels of alloxan induced diabetic rabbits. J. Ayub. Med. Coll. Abbottabad., 19(1): 32-38.
58. Ward DN, Bousfield GR, Moore KH (1991). Gonadotropins. In: Cupps PT, ed. Reproduction in Domestic Animals. San Diego, Calif: Academic Press, pp. 25-67.
59. Weibel ER, Gomez DM (1962). A principle for counting tissue structures on random sections. J. Appl. Physiol. 17: 343-348.
60. Wild S, Sicree R, Roglic G, King H, Green A (2004). Diabetes Care, 27: 1047-1053.
61. Wing TY, Chritensen AK (1982). Morphometric studies on rat seminiferous tubules. Am. J. Anat. 165(1): 13-25.
62. World Health Organization (1980). The WHO Committee on Diabetes Mellitus: Second Report. Technical Report Series 646, World Health Organization, Geneva, p. 61.
63. Zhang X, Linda S, Geiss Y Cheng J, Gloria L, Beckles Edward W, Gregg H, Kahn S (2008). Missed Patient With Diabetes (Mediscape Endocrinol. with DM), www.mediscape.com, accessed 24/09..