Proliferative activity in fibrosing lung diseases: a comparative study of Ki-67 immunoreactivity in diffuse alveolar damage, bronchiolitis obliterans-organizing pneumonia, and usual interstitial pneumonia

Human Pathology

Volumn 40, Issue 8, 2009, Pages 1182-1188

  El Zammar, Ola ^a   Rosenbaum, Paula ^a   Katzenstein, Anna Luise A ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

Author keywords

BOOP; DAD; IPF; Ki 67; RB; UIP

Indexed keywords

KI 67 ANTIGEN;

ACUTE LUNG INJURY; ADULT; AGED; ARTICLE; BRONCHIOLITIS OBLITERANS ORGANIZING PNEUMONIA; CELL PROLIFERATION; COMPARATIVE STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTERSTITIAL PNEUMONIA; KELOID; LUNG ALVEOLUS EPITHELIUM; LUNG ALVEOLUS MACROPHAGE; LUNG FIBROBLAST; LUNG FIBROSIS; MAJOR CLINICAL STUDY; MALE; SKIN SCAR; STATISTICAL ANALYSIS; WOUND HEALING;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CELL COUNT; CELL PROLIFERATION; CHILD; CHILD, PRESCHOOL; CRYPTOGENIC ORGANIZING PNEUMONIA; FEMALE; FIBROBLASTS; HUMANS; KELOID; KI-67 ANTIGEN; LUNG DISEASES, INTERSTITIAL; MALE; MIDDLE AGED; PULMONARY ALVEOLI; PULMONARY FIBROSIS; YOUNG ADULT;

EID: 67650462242     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2009.01.006     Document Type: Article

References (25)

1. Katzenstein A.L.A. Pathogenesis of "fibrosis" in interstitial pneumonia. An electron microscopic study. Hum Pathol 16 (1985) 1015-1024
2. Myers J.L., and Katzenstein A.L.A. Ultrastructural evidence of alveolar epithelial injury in idiopathic bronchiolitis obliterans-organizing pneumonia. Am J Pathol 132 (1988) 102-109
3. Myers J., and Katzenstein A. Epithelial necrosis and alveolar collapse in the pathogenesis of usual interstitial pneumonia. Chest 94 (1989) 1309-1311
4. Katzenstein A.L., Myers J.L., and Mazur M.T. Acute interstitial pneumonia. A clinicopathologic, ultrastructural, and cell kinetic study. Am J Surg Pathol 10 (1986) 256-267
5. Kuhn C., and McDonald J. The roles of the myofibroblast in idiopathic pulmonary fibrosis. Ultrastructural and immunohistochemical features of sites of active extracellular matrix synthesis. Am J Pathol 138 (1991) 1257-1265
6. Ramos C., Montaño M., García-Alvarez J., et al. Fibroblasts from idiopathic pulmonary fibrosis and normal lungs differ in growth rate, apoptosis, and tissue inhibitor of metalloproteinase expression. Am J Respir Cell Mol Biol. 24 (2001) 591-598
7. Hetzel M., Bachem M., Anders D., Trischler G., and Faehling M. Different effects of growth factors on proliferation and matrix production of normal and fibrotic human lung fibroblasts. Lung 183 (2005) 225-237
8. Selman M., King T.E., and Pardo A. Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med 134 (2001) 136-151
9. Cook D.N., Brass D.M., and Schwartz D.A. A matrix for new ideas in pulmonary fibrosis. Am J Respir Cell Molecular Biol 27 (2002) 122-124
10. Crystal R.G., Bitterman P.B., Mossman B., et al. Future research directions in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 166 (2002) 236-246
11. Thannickal V.J., Toews G.B., White E.S., Lynch J.P., and Martinez F.J. Mechanisms of pulmonary fibrosis. Annu Rev Med 55 (2004) 395-417
12. White E.S., Lazar M.H., and Thannickal V.J. Pathogenic mechanisms in usual interstitial pneumonia/idiopathic pulmonary fibrosis. J Pathol 201 (2003) 343-354
13. Bardales R., Xie S., Schaefer R., and Hsu S. Apoptosis is a major pathway responsible for the resolution of type II pneumocytes in acute lung injury. Am J Pathol 149 (1996) 845-852
14. Adamson I.Y., Young L., and Bowden D.H. Relationship of alveolar epithelial injury and repair to the induction of pulmonary fibrosis. Am J Pathol 130 (1988) 377-383
15. Uhal B.D., Joshi I., Hughes W.F., Ramos C., Pardo A., and Selman M. Alveolar epithelial cell death adjacent to underlying myofibroblasts in advanced fibrotic human lung. Am J Physiol 275 (1998) L1192-L1199
16. Selman M., and Pardo A. The epithelial/fibroblastic pathway in the pathogenesis of idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 29 (2003) S93-S96
17. Chilosi M., Poletti V., Zamo A., et al. Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis. Am J Pathol 162 (2003) 1495-1502
18. Willis C., and Borok Z. TGF-β-induced EMT: mechanisms and implications for fibrotic lung disease. Am J Physiol Lung Cell Mol Physiol 293 (2007) L525-L534
19. Selman M., King T.E., and Pardo A. Idiopathic pulmonary fibrosis: prevailing and evolving hypothesis about its pathogenesis and implications for therapy. Ann Intern Med 134 (2001) 136-151
20. Lohmann-Matthes M.L., Steinmuller C., and Franke-Ullmann G. Pulmonary macrophages. Eur Respir J 7 (1994) 1678-1689
21. Noble P., and Homer R. Idiopathic pulmonary fibrosis: new insights into pathogenesis. Clin Chest Med, 25 (2004) 749-758
22. Reynolds H. Lung inflammation and fibrosis: an alveolar macrophage-centered perspective from the 1970s to 1980s. Am J Respir Crit Care Med. 171 (2005) 98-102
23. Guo Z., Zhu Y., Lui B., Zhu Y., Zhao W., and Chen Y. Effects of alveolar macrophage conditioned media from interstitial lung disease patients on the procollagen mRNA expression in human lung fibroblasts. Chin Med Sci J. 11 (1996) 25-27
24. Bitterman P.B., Saltzman L.E., Adelberg S., Ferrans V.J., and Crystal R.G. Alveolar macrophage replication. One mechanism for the expansion of the mononuclear phagocyte population in the chronically inflamed lung. J Clin Invest 74 (1984) 460-469
25. Pforte A., Gerth C., Voss A., et al. Proliferating alveolar macrophages in BAL and lung function changes in interstitial lung disease. Eur Respir J 6 (1993) 951-955