Propofol Clearance and Volume of Distribution Are Increased in Patients with Major Burns

Journal of Clinical Pharmacology

Volumn 49, Issue 7, 2009, Pages 768-772

  Han, Tae Hyung ^a   Greenblatt, David J ^b   Jeevendra Martyn, J A ^c  

^a UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SHRINERS HOSPITALS FOR CHILDREN   (United States)

Author keywords

Cardiac index; Hepatic blood flow; Hypnotics; Pharmacokinetics

Indexed keywords

PROPOFOL;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; BURN; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; FEMALE; HUMAN; INTRAVENOUS ANESTHESIA; MALE;

ADULT; AGED; ANESTHETICS, INTRAVENOUS; BURNS; CASE-CONTROL STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; PROPOFOL;

EID: 67650432533     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1177/0091270009335767     Document Type: Article

References (33)

1. MacLennan N., Heimbach DM, Cullen BF Anesthesia for major thermal injury. Anesthesiology. 1998 ; 89: 749-770. (Pubitemid 28423975)
2. Martyn JA Clinical pharmacology and drug therapy in the burned patient. Anesthesiology. 1986 ; 65: 67-75.
3. Jaehde U., Sorgel F. Clinical pharmacokinetics in patients with burns. Clin Pharmacokinet. 1995 ; 29: 15-28.
4. Sheridan R., Stoddard F., Querzoli E. Management of background pain and anxiety in critically burned children requiring protracted mechanical ventilation. J Burn Care Rehabil. 2001 ; 22: 150-153. (Pubitemid 32285128)
5. Han T., Harmatz JS, Greenblatt DJ, Martyn JAJ. Fentanyl clearance and volume of distribution are increased in patients with major burns. J Clin Pharmacol. 2007 ; 47: 674-680. (Pubitemid 46800421)
6. Martyn J., Greenblatt DJ Lorazepam conjugation is unimpaired in burn trauma. Clin Pharmacol Ther. 1988 ; 43: 250-255. (Pubitemid 18091845)
7. Cote CJ, Petkau AJ Thiopental requirements may be increased in children re-anesthetized at least one year after recovery from extensive thermal injury. Anesth Analg. 1985 ; 64: 1156-1160. (Pubitemid 16258111)
8. Cederholm I., Bengtsson M., Bjorkman S., Choonara I., Rane A. Long term high dose morphine, ketamine and midazolam infusion in a child with burns. Br J Clin Pharmacol. 1990 ; 30: 901-905.
9. Martyn JA, Greenblatt DJ, Abernethy DR Increased cimetidine clearance in burn patients. JAMA. 1985 ; 253: 1288-1291. (Pubitemid 15127845)
10. Martyn JA, Bishop AL, Oliveri MF Pharmacokinetics and pharmacodynamics of ranitidine after burn injury. Clin Pharmacol Ther. 1992 ; 51: 408-414.
11. Martyn JA, Greenblatt DJ, Hagen J., Hoaglin DC Alteration by burn injury of the pharmacokinetics and pharmacodynamics of cimetidine in children. Eur J Clin Pharmacol. 1989 ; 36: 361-367. (Pubitemid 19140038)
12. Martyn JAJ, Fukushima Y., Chon JY, Yang HS Muscle relaxants in burns, trauma, and critical illness. Int Anesthesiol Clin. 2006 ; 44: 123-143.
13. Han TH, Lee JH, Kwak IS, Kil HY, Han KW, Kim KM The relationship between bispectral index and targeted propofol concentration is biphasic in patients with major burns. Acta Anaesthesiol Scand. 2005 ; 49: 85-91.
14. Carsin H. Use of Diprivan in burn patients. Ann Fr Anesth Reanim. 1994 ; 13: 541-544.
15. Galizia JP, Imbenotte M., Hochart D., Zdzitowiecki J., Erb F., Scherpereel P. Pharmacokinetic study of propofol in burn patients [abstract]. Ann Fr Anesth Reanim. 1989 ; 8 (suppl): R157.
16. Sheridan RL, Keaney T., Stoddard F., Enfanto R., Kadillack P., Breault L. Short-term propofol infusion as an adjunct to extubation in burned children. J Burn Care Rehab. 2003 ; 24: 356-360. (Pubitemid 37444510)
17. Kurita T., Morita K., Kazama T., Sato S. Influence of cardiac output on plasma propofol concentrations during constant infusion in swine. Anesthesiology. 2002 ; 96: 1498-1503. (Pubitemid 34587222)
18. De Paepe P., Belpaire FM, Rosseel MT, Van Hoey G., Boon PA, Buylaert WA Influence of hypovolemia on the pharmacokinetics and the electroencephalographic effect of propofol in the rat. Anesthesiology. 2000 ; 93: 1482-1490.
19. Johnson KB, Egan TD, Kern SE, et al. The influence of hemorrhagic shock on propofol: a pharmacokinetic and pharmacodynamic analysis. Anesthesiology. 2003 ; 99: 409-420. (Pubitemid 36909567)
20. Shafer SL. Shock values. Anesthesiology. 2004;101:567-568.
21. Kazama T, Kurita T, Morita K, Nakata J, Sato S. Influence of hemorrhage on propofol pseudo-steady state concentration. Anesthesiology. 2002;97:1156-1161.
22. Kazama T., Morita K., Ikeda T., Kurita T., Sato S. Comparison of predicted induction dose with predetermined physiologic characteristics of patient and with pharmacokinetic models incorporating those characteristics as covariates. Anesthesiology. 2003 ; 98: 299-305. (Pubitemid 36592794)
23. Myburgh JA, Upton RN, Grant C., Martinez A. Epinephrine, norepinephrine and dopamine infusions decrease propofol concentrations during continuous propofol infusion in an ovine model. Intensive Care Med. 2001 ; 27: 276-282. (Pubitemid 32209000)
24. Upton RN, Ludbrook GL, Grant C., Martinez AM Cardiac output is a determinant of the initial concentrations of propofol after short infusion administration. Anesth Analg. 1999 ; 89: 545-552. (Pubitemid 29409795)
25. Takizawa E., Takizawa D., Al-Jahdari WS, et al. Influence of atropine on the dose requirements of propofol in humans. Drug Metab Pharmacokinet. 2006 ; 21: 384-388.
26. Vree TB, Lagerwerf AJ, Bleeker CP, de Grood PM Direct high-performance liquid chromatography determination of propofol and its metabolite quinol with their glucuronide conjugates and preliminary pharmacokinetics in plasma and urine of man. J Chromatogr B Biomed Sci. 1999 ; 721: 217-228. (Pubitemid 29142344)
27. De Paepe P., Belpaire FM, Buylaert WA Pharmacokinetic and pharmacodynamic considerations when treating patients with sepsis and septic shock. Clin Pharmacokinet. 2002 ; 41: 1135-1151. (Pubitemid 35398690)
28. Murat I., Billard V., Vernois J., et al. Pharmacokinetics of propofol after a single dose in children aged 1-3 years with minor burns: comparison of three data analysis approaches. Anesthesiology. 1996 ; 84: 526-532. (Pubitemid 26092524)
29. Wilmore DW Metabolic response to severe surgical illness: overview. World J Surg. 2000 ; 24: 705-711. (Pubitemid 30331846)
30. Takizawa D., Hiraoka H., Goto F., Yamamoto K., Horiuchi R. Human kidneys play an important role in the elimination of propofol. Anesthesiology. 2005 ; 102: 327-330. (Pubitemid 40189080)
31. Kuipers JA, Boer F., Olieman W., Burm AG, Bovill JG First-pass lung uptake and pulmonary clearance of propofol: assessment with a recirculatory indocyanine green pharmacokinetic model. Anesthesiology. 1999 ; 91: 1780-1787.
32. Court MH, Duan SX, Hesse LM, Venkatakrishnan K., Greenblatt DJ Cytochrome P-450 2B6 is responsible for interindividual variability of propofol hydroxylation by human liver microsomes. Anesthesiology. 2001 ; 94: 110-119. (Pubitemid 32055186)
33. Hiraoka H., Yamamoto K., Miyoshi S., et al. Kidneys contribute to the extrahepatic clearance of propofol in humans, but not lungs and brain. Br J Clin Pharmacol. 2005 ; 60: 176-182. (Pubitemid 41075903)